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Coexpression cluster:C2801

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Full id: C2801_Natural_B_CD8_xeroderma_CD34_plasma_Basophils



Phase1 CAGE Peaks

  Short description
Hg19::chr5:133468482..133468495,+ p@chr5:133468482..133468495
+
Hg19::chr8:101507517..101507549,- -
p@chr8:101507517..101507549
Hg19::chr9:116279713..116279734,+ p15@RGS3
Hg19::chrX:53741792..53741809,- p@chrX:53741792..53741809
-


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data


Cell Type
Ontology termp-valuen
lymphoid lineage restricted progenitor cell9.91e-5352
lymphocyte1.74e-5153
common lymphoid progenitor1.74e-5153
nucleate cell3.92e-4955
T cell1.25e-3325
pro-T cell1.25e-3325
leukocyte3.68e-32136
mature alpha-beta T cell9.88e-3018
alpha-beta T cell9.88e-3018
immature T cell9.88e-3018
mature T cell9.88e-3018
immature alpha-beta T cell9.88e-3018
nongranular leukocyte1.18e-29115
hematopoietic lineage restricted progenitor cell3.90e-26120
hematopoietic cell5.67e-25177
hematopoietic stem cell5.76e-24168
angioblastic mesenchymal cell5.76e-24168
hematopoietic oligopotent progenitor cell4.45e-21161
hematopoietic multipotent progenitor cell4.45e-21161
CD8-positive, alpha-beta T cell1.71e-1711
lymphocyte of B lineage1.11e-1524
pro-B cell1.11e-1524
CD4-positive, alpha-beta T cell2.68e-126
circulating cell1.92e-106
natural killer cell9.57e-083
pro-NK cell9.57e-083
basophil2.71e-073
Uber Anatomy
Ontology termp-valuen
hemopoietic organ2.96e-127
immune organ2.96e-127
blood1.02e-1015
haemolymphatic fluid1.02e-1015
organism substance1.02e-1015
thymus1.19e-074
hemolymphoid system gland1.19e-074
thymic region1.19e-074
pharyngeal gland1.19e-074
thymus primordium1.19e-074


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0938548
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.10.244769
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.25531
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.10.396851
MA0056.10
MA0057.10.248209
MA0058.11.47358
MA0059.10.604454
MA0060.10.393285
MA0061.10.946082
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.14.42843
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.10.182167
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.11.32557
MA0095.10
MA0098.10
MA0100.11.9583
MA0101.10.539569
MA0103.10.521546
MA0105.10.656404
MA0106.10.869173
MA0107.11.1497
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.11.09982
MA0145.10.569905
MA0146.10.8309
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.931615
MA0035.20.778873
MA0039.20.0247757
MA0138.20.928035
MA0002.21.75253
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.20.551048
MA0065.21.09513
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.10.229241
MA0155.10.180766
MA0156.11.37856
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.10.0928415
MA0163.10.253219
MA0164.12.08227
MA0080.22.27911
MA0018.20.870662
MA0099.20.7872
MA0079.20.00910927
MA0102.21.75932
MA0258.11.07498
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BATF#10538318.26835134422770.0002681660105721290.00286809933211906
BCL11A#53335214.18472755180350.007108328585298740.0296302825432056
BCL3#602217.27355140186920.004834494208076070.022679321771426
EBF1#187936.679850134926750.005184294118278910.0240609026982594
IRF4#3662316.43588451505810.0003669431395554610.00366028410239091
MEF2A#4205314.0574231822330.0005830038854186610.00488945176176339
NFKB1#479045.488063424193840.001102199566301980.00769006750651428
PAX5#507935.002174148383370.01196533174786410.04351897204998
POU2F2#545236.829593043306890.004860473775203740.0227735765189997
SPI1#668836.153242631392040.006580387113059030.0281117948910203



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.