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UBERON:0002342

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Name:neural crest
Namespace:FANTOM
Definition:"The neural crest, a transient component of the ectoderm, is located in between the neural tube and the epidermis (or the free margins of the neural folds) of an embryo during neural tube formation. Neural crest cells quickly migrate during or shortly after neurulation, an embryological event marked by neural tube closure." [Wikipedia:Neural_crest]
Xrefs:
links:

AAO:0010578
BTO:0001764
EHDAA2:0004419
FMA:86666
GAID:1310
[ Neural_Crest.png Neural_Crest.png]
[ 200px-Gray644.png 200px-Gray644.png]
MAT:0000066
MESH:A.16.254.600
MIAA:0000066
ncithesaurus:Neural_Crest
SCTID:361462002
TAO:0000045
VHOG:0000057
XAO:0000048

ZFA:0000045
Synonyms: "crista neuralis" RELATED LATIN [Wikipedia:Neural_crest]
Comments:Editor note: consider including subclasses for pre- and post- migratory (e.g. sheets/paths/streams). Taxon notes: A well developed neural crest population is present in lampreys (Horigome et al. 1999 ; Tomsa & Langeland, 1999) and gnathostomes. chordate fossils from the early Cambrian (Yunnanozoan and Haikouella) with apparent neural-crest derived structures (pharyngeal denticles and pharyngeal skeletons resembling the striped mucocartilage of the branchial bars in lamprey ammocoete larvae), suggests that neural crest arose very early in vertebrate evolution (Chen et al. 1999; Holland & Chen, 2001). The invertebrate chordates apparently lack defini- tive neural crest. One marker of migrating neural crest in some vertebrates, the antibody HNK1, does not recognize any cells in amphioxus embryos (Holland, unpublished). Even so, in both amphioxus and tunicates, cells at the edges of the neural plate and adjacent nonneural ectoderm share some properties of neural crest[PMID:11523831]. Gene notes: Many factors and genes, such as Pax3 (Tremblay et al., 1995), slug (Nieto et al., 1994), AP-2 (Zhang et al., 1996; Schorle et al., 1996), and Wnt-1/3a (Ikeya et al., 1997) are expressed in the dorsal most region of the neural tube, and have been shown to be involved in the generation of neural crest cells.
Alt_id: UBERON:FMA_86666-MIAA_0000066-XAO_0000048-ZFA_0000045
Subset: uberon_slim
vertebrate_core

Ontology association
Each term has an is_a parent in the Uberon Ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to UBERON ontologies.

link to ontology dataset
data


Parents

is_a:UBERON:0004121(ectoderm-derived structure),UBERON:0010314(structure with developmental contribution from neural crest),UBERON:0010316(germ layer / neural crest)
develops_from:UBERON:0003075(neural plate),UBERON:0005062(neural fold)
part_of:UBERON:0002346(neurectoderm)



Children

is a:UBERON:0003849 (mesencephalic neural crest),UBERON:0003852 (rhombencephalon neural crest)
develops from:UBERON:0001236 (adrenal medulla),UBERON:0001808 (parasympathetic ganglion),UBERON:0002062 (endocardial cushion),UBERON:0004363 (pharyngeal arch artery),UBERON:0005427 (corneal primordium),UBERON:0010253 (1st arch maxillary mesenchyme from neural crest),UBERON:0010259 (1st arch mesenchyme from neural crest),UBERON:0010313 (neural crest-derived structure),UBERON:0010334 (maxillary process mesenchyme from neural crest),UBERON:0010359 (pharyngeal arch mesenchyme from neural crest),UBERON:0011156 (facial skeleton),UBERON:0014387 (mesenchyme derived from neural crest)
part of:UBERON:0003099 (cranial neural crest),UBERON:0005428 (vagal neural crest),CL:0007004 (premigratory neural crest cell)

Ontology Tree: Loaded from BioPortal


FF samples
It includes FANTOM5 samples that overlay the Uberon ontology




Enrichment analysis: top 100 FFCP enriched with this ontology term TOP 100 FANTOM5 Cage Peaks enriched with UBERON:0002342 (neural crest), sorted by p-values
Analyst: Hideya Kawaji

link to source dataset
human : data
mouse : data


P-valueFFCPShort description
1.58e-86FFCP PHASE1:Mm9::chr6:52158594..52158603,-#_21fae4a52b9440e92c55bc058ee0c4b5p@chr6:52158594..52158603, -
1.58e-86FFCP PHASE2:Mm9::chr6:52158594..52158603,-#_21fae4a52b9440e92c55bc058ee0c4b5p@chr6:52158594..52158603, -
6.04e-65FFCP PHASE2:Mm9::chr4:152858080..152858084,-#_ec89d09ebcd73a08376030afaf546de1p@chr4:152858080..152858084, -
6.04e-65FFCP PHASE1:Mm9::chr4:152858080..152858084,-#_ec89d09ebcd73a08376030afaf546de1p@chr4:152858080..152858084, -
3.28e-58FFCP PHASE2:Mm9::chr7:143239748..143239753,+#_2f47b54d5e9a913463a0c919340a9edfp@chr7:143239748..143239753, +
3.28e-58FFCP PHASE1:Mm9::chr7:143239748..143239753,+#_2f47b54d5e9a913463a0c919340a9edfp@chr7:143239748..143239753, +
4.85e-45FFCP PHASE1:Hg19::chr7:25815812..25815822,-#_9bbc48b138a7f3930577023289b10b77p@chr7:25815812..25815822, -
4.85e-45FFCP PHASE2:Hg19::chr7:25815812..25815822,-#_9bbc48b138a7f3930577023289b10b77p@chr7:25815812..25815822, -
1.18e-44FFCP PHASE2:Mm9::chr1:88008549..88008559,-#_e63cce912ea7b56f3efea60d358b3c6cp4@Htr2b
1.18e-44FFCP PHASE1:Mm9::chr1:88008549..88008559,-#_e63cce912ea7b56f3efea60d358b3c6cp4@Htr2b
3.27e-44FFCP PHASE2:Mm9::chr2:74583733..74583738,+#_dc0dcb5409991d46290419b764dfeacap13@Hoxd3
3.27e-44FFCP PHASE1:Mm9::chr2:74583733..74583738,+#_dc0dcb5409991d46290419b764dfeacap13@Hoxd3
4.58e-44FFCP PHASE1:Mm9::chr13:96388617..96388624,-#_a0fac1cd6e659a0f4e36e86880efc41cp4@F2r
4.58e-44FFCP PHASE2:Mm9::chr13:96388617..96388624,-#_a0fac1cd6e659a0f4e36e86880efc41cp4@F2r
8.97e-44FFCP PHASE2:Mm9::chr5:88358803..88358820,+#_a53361114d3fbc9f00245d2e88beaabep@chr5:88358803..88358820, +
8.97e-44FFCP PHASE1:Mm9::chr5:88358803..88358820,+#_a53361114d3fbc9f00245d2e88beaabep@chr5:88358803..88358820, +
2.0e-40FFCP PHASE2:Hg19::chr12:3373147..3373149,-#_b0e1401a3219e53def98254e3e965f3cp@chr12:3373147..3373149, -
2.0e-40FFCP PHASE1:Hg19::chr12:3373147..3373149,-#_b0e1401a3219e53def98254e3e965f3cp@chr12:3373147..3373149, -
4.15e-39FFCP PHASE1:Mm9::chr11:4397590..4397595,-#_5f600a490d9d917c37ef1ee75cf68f6fp@chr11:4397590..4397595, -
4.15e-39FFCP PHASE2:Mm9::chr11:4397590..4397595,-#_5f600a490d9d917c37ef1ee75cf68f6fp@chr11:4397590..4397595, -
1.17e-38FFCP PHASE2:Mm9::chr9:35352286..35352290,-#_d8f5565b4dc4e265eb15188b4a0f3929p@chr9:35352286..35352290, -
1.17e-38FFCP PHASE1:Mm9::chr9:35352286..35352290,-#_d8f5565b4dc4e265eb15188b4a0f3929p@chr9:35352286..35352290, -
1.56e-38FFCP PHASE1:Mm9::chr15:102928215..102928218,-#_356e76700b96694d4c85300dc9227ec6p@chr15:102928215..102928218, -
1.56e-38FFCP PHASE2:Mm9::chr15:102928215..102928218,-#_356e76700b96694d4c85300dc9227ec6p@chr15:102928215..102928218, -
3.73e-38FFCP PHASE2:Mm9::chr11:96164868..96164875,+#_80ce19cd6d1ae044784ffeaffde9d17dp5@Hoxb5
3.73e-38FFCP PHASE1:Mm9::chr11:96164868..96164875,+#_80ce19cd6d1ae044784ffeaffde9d17dp5@Hoxb5
4.98e-38FFCP PHASE1:Mm9::chr11:96176093..96176104,+#_42f3f51f4fcb021ab7717da9f3780d33p@chr11:96176093..96176104, +
4.98e-38FFCP PHASE2:Mm9::chr11:96176093..96176104,+#_42f3f51f4fcb021ab7717da9f3780d33p@chr11:96176093..96176104, +
3.44e-36FFCP PHASE2:Hg19::chr1:20355975..20355980,-#_bdbeb03d02d0ae2c9790ac091289376dp@chr1:20355975..20355980, -
3.44e-36FFCP PHASE1:Hg19::chr1:20355975..20355980,-#_bdbeb03d02d0ae2c9790ac091289376dp@chr1:20355975..20355980, -
3.67e-34FFCP PHASE2:Mm9::chr8:11952680..11952690,+#_90dbffe2a677907454880ece8f3cc512p@chr8:11952680..11952690, +
3.67e-34FFCP PHASE1:Mm9::chr8:11952680..11952690,+#_90dbffe2a677907454880ece8f3cc512p@chr8:11952680..11952690, +
4.74e-34FFCP PHASE2:Mm9::chr10:90644180..90644195,-#_7f780626be363cc4f577c7034ce7ca20p@chr10:90644180..90644195, -
4.74e-34FFCP PHASE2:Mm9::chr16:5855821..5855836,+#_7f780626be363cc4f577c7034ce7ca20p@chr16:5855821..5855836, +
4.74e-34FFCP PHASE1:Mm9::chr10:90644180..90644195,-#_7f780626be363cc4f577c7034ce7ca20p@chr10:90644180..90644195, -
4.74e-34FFCP PHASE1:Mm9::chr16:5855821..5855836,+#_7f780626be363cc4f577c7034ce7ca20p@chr16:5855821..5855836, +
6.12e-34FFCP PHASE2:Mm9::chr2:31305411..31305419,+#_7c67ede9e39277859e395370652c94d1p@chr2:31305411..31305419, +
6.12e-34FFCP PHASE1:Mm9::chr2:31305411..31305419,+#_7c67ede9e39277859e395370652c94d1p@chr2:31305411..31305419, +
1.69e-33FFCP PHASE1:Mm9::chr16:5855860..5855872,+#_10744a04e60f737c3750d51d81f40a8ap@chr16:5855860..5855872, +
1.69e-33FFCP PHASE2:Mm9::chr16:5855860..5855872,+#_10744a04e60f737c3750d51d81f40a8ap@chr16:5855860..5855872, +
9.86e-33FFCP PHASE1:Mm9::chr12:88020400..88020411,+#_29e50409ff3015169bfd7bd454f32defp@chr12:88020400..88020411, +
9.86e-33FFCP PHASE2:Mm9::chr12:88020400..88020411,+#_29e50409ff3015169bfd7bd454f32defp@chr12:88020400..88020411, +
1.16e-30FFCP PHASE1:Mm9::chr6:52158693..52158704,-#_a06845d1556f94917899c9d9a6adcbd8p3@Hoxa6
1.16e-30FFCP PHASE2:Mm9::chr6:52158693..52158704,-#_a06845d1556f94917899c9d9a6adcbd8p3@Hoxa6
1.86e-30FFCP PHASE1:Hg19::chr1:237331032..237331036,+#_f0212822401a7e3db6009f574b0ce347p@chr1:237331032..237331036, +
1.86e-30FFCP PHASE2:Hg19::chr1:237331032..237331036,+#_f0212822401a7e3db6009f574b0ce347p@chr1:237331032..237331036, +
3.39e-30FFCP PHASE1:Hg19::chr13:111935498..111935509,+#_51aacf9d7397b1a39f2e7d623e22a6bbp35@ARHGEF7
3.39e-30FFCP PHASE2:Hg19::chr13:111935498..111935509,+#_51aacf9d7397b1a39f2e7d623e22a6bbp35@ARHGEF7
4.54e-30FFCP PHASE1:Mm9::chr11:96168366..96168369,+#_3037ef842bc691e5f952fcfbd515e969p@chr11:96168366..96168369, +
4.54e-30FFCP PHASE1:Mm9::chr11:113795301..113795315,+#_3037ef842bc691e5f952fcfbd515e969p@chr11:113795301..113795315, +
4.54e-30FFCP PHASE2:Mm9::chr11:113795301..113795315,+#_3037ef842bc691e5f952fcfbd515e969p@chr11:113795301..113795315, +
4.54e-30FFCP PHASE2:Mm9::chr11:96168366..96168369,+#_3037ef842bc691e5f952fcfbd515e969p@chr11:96168366..96168369, +
5.61e-30FFCP PHASE2:Mm9::chr14:20570183..20570190,+#_dadb9c81dfdbad24507f9db4ed55b2e7p3@Nid2
5.61e-30FFCP PHASE1:Mm9::chr14:20570183..20570190,+#_dadb9c81dfdbad24507f9db4ed55b2e7p3@Nid2
5.7e-30FFCP PHASE2:Mm9::chr8:11782453..11782481,+#_92534a4706a61ebca8193869eaf5a1dbp25@Arhgef7
5.7e-30FFCP PHASE1:Mm9::chr8:11782453..11782481,+#_92534a4706a61ebca8193869eaf5a1dbp25@Arhgef7
7.14e-30FFCP PHASE1:Mm9::chr7:98820891..98820900,+#_1b351471f2379939fa97e278ee8c2c0ep34@Dlg2
7.14e-30FFCP PHASE2:Mm9::chr7:98820891..98820900,+#_1b351471f2379939fa97e278ee8c2c0ep34@Dlg2
1.12e-29FFCP PHASE2:Mm9::chr6:118116455..118116458,-#_ccb8e8e35b9f01a5a14ed771197111d7p@chr6:118116455..118116458, -
1.12e-29FFCP PHASE1:Mm9::chr6:118116455..118116458,-#_ccb8e8e35b9f01a5a14ed771197111d7p@chr6:118116455..118116458, -
1.4e-29FFCP PHASE2:Mm9::chr2:119624214..119624225,+#_ebddec4ce9a0a4d8ae6c1936e8cafcfdp7@Tyro3
1.4e-29FFCP PHASE1:Mm9::chr2:119624214..119624225,+#_ebddec4ce9a0a4d8ae6c1936e8cafcfdp7@Tyro3
1.54e-29FFCP PHASE2:Mm9::chr1:88007341..88007350,-#_f9b480dc613af52c007a4f3d97c50cc0p7@Htr2b
1.54e-29FFCP PHASE1:Mm9::chr1:88007341..88007350,-#_f9b480dc613af52c007a4f3d97c50cc0p7@Htr2b
1.54e-29FFCP PHASE2:Mm9::chr5:88358878..88358890,+#_f9b480dc613af52c007a4f3d97c50cc0p@chr5:88358878..88358890, +
1.54e-29FFCP PHASE1:Mm9::chr5:88358878..88358890,+#_f9b480dc613af52c007a4f3d97c50cc0p@chr5:88358878..88358890, +
2.19e-29FFCP PHASE2:Mm9::chr15:90848413..90848436,-#_94c004688d015cd067326d4cb3a7861bp@chr15:90848413..90848436, -
2.19e-29FFCP PHASE1:Mm9::chr15:90848413..90848436,-#_94c004688d015cd067326d4cb3a7861bp@chr15:90848413..90848436, -
3.42e-29FFCP PHASE1:Mm9::chr9:20777404..20777418,+#_68020684771d1039c05a54203b4a5bccp@chr9:20777404..20777418, +
3.42e-29FFCP PHASE2:Mm9::chr9:20777404..20777418,+#_68020684771d1039c05a54203b4a5bccp@chr9:20777404..20777418, +
7.38e-28FFCP PHASE1:Mm9::chr6:52134126..52134150,-#_3960efae35bf58596c60583dd9bd00b9p3@Hoxa3
7.38e-28FFCP PHASE2:Mm9::chr6:52134126..52134150,-#_3960efae35bf58596c60583dd9bd00b9p3@Hoxa3
9.07e-28FFCP PHASE1:Mm9::chr11:106874215..106874219,+#_5694b714e7cc7e71ee392899684de0d9p@chr11:106874215..106874219, +
9.07e-28FFCP PHASE2:Mm9::chr11:106874215..106874219,+#_5694b714e7cc7e71ee392899684de0d9p@chr11:106874215..106874219, +
1.11e-27FFCP PHASE1:Mm9::chr5:46030754..46030764,-#_4a08105672d6e69008163f9fc53b65fcp9@Fam184b
1.11e-27FFCP PHASE2:Mm9::chr5:46030754..46030764,-#_4a08105672d6e69008163f9fc53b65fcp9@Fam184b
1.37e-27FFCP PHASE1:Mm9::chr11:96175972..96175978,+#_220d3f082bb82bcc5d8c18bc64315d49p@chr11:96175972..96175978, +
1.37e-27FFCP PHASE2:Mm9::chr11:96175972..96175978,+#_220d3f082bb82bcc5d8c18bc64315d49p@chr11:96175972..96175978, +
2.06e-27FFCP PHASE1:Mm9::chr5:67486110..67486118,-#_0517b937b371607aaa843ec6fcc50bf4p@chr5:67486110..67486118, -
2.06e-27FFCP PHASE2:Mm9::chr5:67486110..67486118,-#_0517b937b371607aaa843ec6fcc50bf4p@chr5:67486110..67486118, -
2.72e-27FFCP PHASE1:Hg19::chr1:11907265..11907271,-#_fc9f8bbf3e6874f00e23a75ff18f3921p9@NPPA
2.72e-27FFCP PHASE2:Hg19::chr2:18116344..18116353,+#_fc9f8bbf3e6874f00e23a75ff18f3921p@chr2:18116344..18116353, +
2.72e-27FFCP PHASE2:Hg19::chr1:11907265..11907271,-#_fc9f8bbf3e6874f00e23a75ff18f3921p9@NPPA
2.72e-27FFCP PHASE2:Hg19::chr6:6739548..6739577,-#_fc9f8bbf3e6874f00e23a75ff18f3921p@chr6:6739548..6739577, -
2.72e-27FFCP PHASE1:Hg19::chr2:18116344..18116353,+#_fc9f8bbf3e6874f00e23a75ff18f3921p@chr2:18116344..18116353, +
2.72e-27FFCP PHASE1:Hg19::chr6:6739548..6739577,-#_fc9f8bbf3e6874f00e23a75ff18f3921p@chr6:6739548..6739577, -
2.72e-27FFCP PHASE1:Hg19::chr17:39023189..39023197,-#_fc9f8bbf3e6874f00e23a75ff18f3921p2@KRT12
2.72e-27FFCP PHASE2:Hg19::chr17:39023189..39023197,-#_fc9f8bbf3e6874f00e23a75ff18f3921p2@KRT12
5.7e-27FFCP PHASE1:Mm9::chr1:65358027..65358031,+#_5940e8bb8e082868475a14c0f7ce3114p1@Pth2r
5.7e-27FFCP PHASE2:Mm9::chr1:65358027..65358031,+#_5940e8bb8e082868475a14c0f7ce3114p1@Pth2r
8.55e-27FFCP PHASE2:Mm9::chr3:59108872..59108875,+#_34f6502ee7f889aef486aa0ca54d5e1bp@chr3:59108872..59108875, +
8.55e-27FFCP PHASE1:Mm9::chr3:59108872..59108875,+#_34f6502ee7f889aef486aa0ca54d5e1bp@chr3:59108872..59108875, +
1.84e-26FFCP PHASE2:Hg19::chr11:46337652..46337682,+#_1f9361bd80fa7450f46df9710d9f4ea9p16@CREB3L1
1.84e-26FFCP PHASE1:Hg19::chr11:46337652..46337682,+#_1f9361bd80fa7450f46df9710d9f4ea9p16@CREB3L1
3.49e-26FFCP PHASE1:Mm9::chr1:94648758..94648763,+#_3d3da600c95f261681675409593e5484p@chr1:94648758..94648763, +
3.49e-26FFCP PHASE2:Mm9::chr1:94648758..94648763,+#_3d3da600c95f261681675409593e5484p@chr1:94648758..94648763, +
3.6e-26FFCP PHASE1:Hg19::chrX:112324334..112324339,-#_bb71da86eeed83312452972ee8a6da6ep@chrX:112324334..112324339, -
3.6e-26FFCP PHASE2:Hg19::chrX:112324334..112324339,-#_bb71da86eeed83312452972ee8a6da6ep@chrX:112324334..112324339, -
4.66e-26FFCP PHASE1:Hg19::chr2:220491902..220491915,+#_81645274208ed83b04565bfe46bd1d9bp11@SLC4A3
4.66e-26FFCP PHASE2:Hg19::chr2:220491902..220491915,+#_81645274208ed83b04565bfe46bd1d9bp11@SLC4A3










Property "Property value" (as page type) with input value "UBPROP:0000001 "A cell population arising from the dorsolateral aspect of the central nervous system primordium during the segmentation period, and later migrating along stereotyped pathways to give rise to a diverse and well-defined set of cell types including pigment cells, peripheral neurons and glia, and head cartilage. Kimmel et al, 1995.[TAO]" xsd:string" contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process., Property "Property value" (as page type) with input value "UBPROP:0000001 "Migratory cell population which delaminates from neural tube, borders surface ectoderm and neural ectoderm, and gives rise to many different tissue types.[AAO]" xsd:string" contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process., Property "Property value" (as page type) with input value "UBPROP:0000002 "relationship type change: differentiates_from ectoderm (AAO:0000137) CHANGED TO: develops_from ectoderm (UBERON:0000924)[AAO]" xsd:string" contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.