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Coexpression cluster:C3809

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Full id: C3809_granulocyte_Astrocyte_Trabecular_acute_Meningeal_Renal_Myoblast



Phase1 CAGE Peaks

Hg19::chr19:4910094..4910138,+p3@UHRF1
Hg19::chr19:4910143..4910175,+p2@UHRF1
Hg19::chr19:4910177..4910205,+p4@UHRF1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
animal cell5.15e-19679
eukaryotic cell5.15e-19679
native cell3.21e-13722
embryonic cell6.72e-11250
somatic cell1.41e-09588
fibroblast3.08e-0976
epithelial cell1.09e-08253
non-terminally differentiated cell5.74e-08106
neurectodermal cell1.50e-0759
epithelial cell of nephron1.88e-0715
ectodermal cell1.89e-0772
migratory neural crest cell2.08e-0741
neural cell5.94e-0725
Uber Anatomy
Ontology termp-valuen
anterior segment of eyeball1.17e-0714
nephron epithelium1.88e-0715
renal tubule1.88e-0715
nephron tubule1.88e-0715
nephron1.88e-0715
uriniferous tubule1.88e-0715
nephrogenic mesenchyme1.88e-0715
cortex8.42e-0715
camera-type eye8.61e-0720
simple eye8.61e-0720
immature eye8.61e-0720
ocular region8.61e-0720
eyeball of camera-type eye8.61e-0720
optic cup8.61e-0720
optic vesicle8.61e-0720
eye primordium8.61e-0720
Disease
Ontology termp-valuen
cancer6.71e-19235
disease of cellular proliferation1.60e-18239
hematologic cancer2.27e-1751
immune system cancer2.27e-1751
leukemia1.28e-1639
myeloid leukemia3.71e-1431
organ system cancer1.04e-10137


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CCNT2#90536.336201576962630.003930750035764890.0190030830433389
CHD2#1106310.34402283411690.0009033701102746880.00660416288303081
E2F1#186934.907389214879320.008460985347239390.0325376260652601
E2F4#1874312.66806031528440.0004917987006298980.00437206030771927
EGR1#195834.988179094810140.008056488137383440.032061102140687
ETS1#211339.728760922202340.001085840092584840.00762277700003144
FOS#235338.99795530889440.001372499272417130.00897460878487181
GABPB1#255337.067683836182170.002832212825417420.0154099231713347
IRF1#365937.63716375356390.002244692747297240.0128070727033585
MXI1#460139.96157162875930.001011470541259020.00720284821072896
NFYA#4800318.42558069983050.0001598135507814160.0019965032811077
NFYB#4801316.75979325353650.0002123649923296180.00245834487185912
NRF1#4899312.21027944771090.0005492172401020010.00471165593387653
SIN3A#2594235.408884726815140.006318961977991520.0276741757881267
SP1#666735.69838137814090.005403962701712170.0246499152954279
SP2#6668326.15353049384465.58768218891694e-050.000940183567147246
ZBTB7A#5134137.35190930787590.002516255860282270.014018737106157



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.