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Coexpression cluster:C2716

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Full id: C2716_Osteoblast_leiomyoma_Preadipocyte_Adipocyte_mesenchymal_Smooth_Mesothelial



Phase1 CAGE Peaks

  Short description
Hg19::chr3:124606049..124606060,- p9@ITGB5
Hg19::chr3:124606074..124606198,- p1@ITGB5
Hg19::chr3:124606201..124606223,- p2@ITGB5
Hg19::chr3:124606225..124606243,- p6@ITGB5


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data


Uber Anatomy
Ontology termp-valuen
epithelial tube5.49e-19117
trunk1.37e-17199
organism subdivision1.04e-16264
multi-cellular organism2.30e-16656
splanchnic layer of lateral plate mesoderm5.13e-1683
trunk mesenchyme5.28e-16122
mesenchyme8.88e-15160
entire embryonic mesenchyme8.88e-15160
epithelial vesicle1.37e-1478
unilaminar epithelium3.58e-14148
multilaminar epithelium1.88e-1383
anatomical system3.37e-13624
anatomical group4.96e-13625
somite1.04e-1271
presomitic mesoderm1.04e-1271
presumptive segmental plate1.04e-1271
dermomyotome1.04e-1271
trunk paraxial mesoderm1.04e-1271
dense mesenchyme tissue1.25e-1273
artery2.22e-1242
arterial blood vessel2.22e-1242
arterial system2.22e-1242
paraxial mesoderm2.77e-1272
presumptive paraxial mesoderm2.77e-1272
vasculature3.34e-1278
vascular system3.34e-1278
epithelial tube open at both ends6.48e-1259
blood vessel6.48e-1259
blood vasculature6.48e-1259
vascular cord6.48e-1259
cell layer9.36e-12309
vessel1.38e-1168
epithelium1.50e-11306
skeletal muscle tissue3.07e-1162
striated muscle tissue3.07e-1162
myotome3.07e-1162
muscle tissue4.45e-1164
musculature4.45e-1164
musculature of body4.45e-1164
circulatory system7.58e-11112
cardiovascular system1.42e-10109
systemic artery1.46e-1033
systemic arterial system1.46e-1033
multi-tissue structure3.11e-09342
primordium1.32e-08160
organ component layer1.68e-0866
anatomical conduit6.00e-08240
mesoderm1.09e-07315
mesoderm-derived structure1.09e-07315
presumptive mesoderm1.09e-07315
surface structure1.57e-0799
adipose tissue2.22e-0714
integument2.36e-0746
integumental system2.36e-0746
anatomical cluster2.95e-07373
aorta3.35e-0721
aortic system3.35e-0721
subdivision of trunk5.53e-07112


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.12.39007
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.16.90671
MA0017.11.41335
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.11.30988
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.10.125954
MA0056.10
MA0057.10.69331
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.10.360128
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.10.00636811
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.10.536981
MA0089.10
MA0090.11.54523
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.10.539569
MA0103.10.521546
MA0105.10.232357
MA0106.10.869173
MA0107.10.453492
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.11.98562
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.10.430413
MA0145.11.70272
MA0146.10.8309
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.24.95563
MA0138.20.928035
MA0002.20.379056
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.25.79077
MA0065.20.199162
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.10.229241
MA0155.11.02191
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.11.57817
MA0163.10.539587
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.24.43857
MA0102.21.75932
MA0258.11.07498
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CCNT2#90546.336201576962630.0006203100587215640.00513063769880585
E2F1#186944.907389214879320.001724022357361790.010665511845783
EGR1#195844.988179094810140.001615011500076050.0101577950049047
ETS1#211349.728760922202340.0001115955317418140.00154718249563033
HEY1#2346244.040111043105710.00375304636917980.018641004886611
HMGN3#932448.178547723350590.0002234570284440470.00248457666279866
MYC#460945.22228187160940.001344309395272740.0088865326243996
SMARCB1#6598418.25271578115749.00423392720929e-060.000241995158806951
TAF1#687243.343046285745290.008005664898701650.0322832401388278
TAF7#6879411.43306940492395.85061525419808e-050.00097081729668445
TBP#690843.706770687096390.005296377814784350.024469096814928
ZNF263#1012748.221841637010680.0002187871180958320.00249453142214089



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.