MCL coexpression mm9:914
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0031234 | extrinsic to internal side of plasma membrane | 0.0134302590628322 |
| GO:0015696 | ammonium transport | 0.0134302590628322 |
| GO:0008519 | ammonium transmembrane transporter activity | 0.0134302590628322 |
| GO:0015695 | organic cation transport | 0.0134302590628322 |
| GO:0016188 | synaptic vesicle maturation | 0.0134302590628322 |
| GO:0015101 | organic cation transmembrane transporter activity | 0.0134302590628322 |
| GO:0009898 | internal side of plasma membrane | 0.0134302590628322 |
| GO:0005886 | plasma membrane | 0.0134302590628322 |
| GO:0042043 | neurexin binding | 0.0134302590628322 |
| GO:0048488 | synaptic vesicle endocytosis | 0.0134302590628322 |
| GO:0042220 | response to cocaine | 0.0134302590628322 |
| GO:0014073 | response to tropane | 0.0134302590628322 |
| GO:0048169 | regulation of long-term neuronal synaptic plasticity | 0.0143232547723708 |
| GO:0016050 | vesicle organization and biogenesis | 0.0143232547723708 |
| GO:0014069 | postsynaptic density | 0.0143232547723708 |
| GO:0048168 | regulation of neuronal synaptic plasticity | 0.0156643429534549 |
| GO:0014070 | response to organic cyclic substance | 0.0168471944875181 |
| GO:0043279 | response to alkaloid | 0.0169047651991126 |
| GO:0007185 | transmembrane receptor protein tyrosine phosphatase signaling pathway | 0.0187066087753133 |
| GO:0048167 | regulation of synaptic plasticity | 0.0187066087753133 |
| GO:0050803 | regulation of synapse structure and activity | 0.0187066087753133 |
| GO:0048489 | synaptic vesicle transport | 0.0187066087753133 |
| GO:0010033 | response to organic substance | 0.0225536707671382 |
| GO:0016324 | apical plasma membrane | 0.0357297021096922 |
| GO:0019897 | extrinsic to plasma membrane | 0.0357297021096922 |
| GO:0019717 | synaptosome | 0.0357297021096922 |
| GO:0019898 | extrinsic to membrane | 0.0456120692889139 |
| GO:0045177 | apical part of cell | 0.0490610155853036 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| CNS neuron (sensu Vertebrata) | 6.16e-19 | 23 |
| neuroblast (sensu Vertebrata) | 6.16e-19 | 23 |
| neuron | 2.51e-17 | 33 |
| neuronal stem cell | 2.51e-17 | 33 |
| neuroblast | 2.51e-17 | 33 |
| electrically signaling cell | 2.51e-17 | 33 |
| neural cell | 4.40e-13 | 43 |
| electrically responsive cell | 1.26e-12 | 39 |
| electrically active cell | 1.26e-12 | 39 |
| ectodermal cell | 1.78e-12 | 44 |
| neurectodermal cell | 1.78e-12 | 44 |
| non-terminally differentiated cell | 7.22e-10 | 49 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
| MA0003.1 | 0.400153 |
| MA0004.1 | 0.434673 |
| MA0006.1 | 0.271714 |
| MA0007.1 | 0.419994 |
| MA0009.1 | 0.870101 |
| MA0014.1 | 0.0611475 |
| MA0017.1 | 0.296816 |
| MA0019.1 | 0.688051 |
| MA0024.1 | 0.826339 |
| MA0025.1 | 1.10341 |
| MA0027.1 | 2.51754 |
| MA0028.1 | 0.281528 |
| MA0029.1 | 0.804619 |
| MA0030.1 | 0.811181 |
| MA0031.1 | 0.775627 |
| MA0038.1 | 0.577528 |
| MA0040.1 | 0.882616 |
| MA0041.1 | 0.360875 |
| MA0042.1 | 0.348174 |
| MA0043.1 | 0.966833 |
| MA0046.1 | 0.906029 |
| MA0048.1 | 0.335404 |
| MA0050.1 | 0.472794 |
| MA0051.1 | 0.586414 |
| MA0052.1 | 0.890676 |
| MA0055.1 | 0.117901 |
| MA0056.1 | 0 |
| MA0057.1 | 0.0935008 |
| MA0058.1 | 0.341628 |
| MA0059.1 | 0.353484 |
| MA0060.1 | 0.197678 |
| MA0061.1 | 0.224905 |
| MA0063.1 | 0 |
| MA0066.1 | 0.566617 |
| MA0067.1 | 1.21448 |
| MA0068.1 | 0.0965831 |
| MA0069.1 | 0.891016 |
| MA0070.1 | 0.881319 |
| MA0071.1 | 0.471969 |
| MA0072.1 | 0.872842 |
| MA0073.1 | 0.00886773 |
| MA0074.1 | 0.531046 |
| MA0076.1 | 0.315013 |
| MA0077.1 | 0.851175 |
| MA0078.1 | 0.61926 |
| MA0081.1 | 0.375851 |
| MA0083.1 | 0.96604 |
| MA0084.1 | 1.54225 |
| MA0087.1 | 0.922929 |
| MA0088.1 | 1.79592 |
| MA0089.1 | 0 |
| MA0090.1 | 0.401197 |
| MA0091.1 | 0.447561 |
| MA0092.1 | 0.401504 |
| MA0093.1 | 0.289361 |
| MA0095.1 | 0 |
| MA0098.1 | 0 |
| MA0100.1 | 1.29122 |
| MA0101.1 | 0.362124 |
| MA0103.1 | 0.307078 |
| MA0105.1 | 1.33477 |
| MA0106.1 | 0.626997 |
| MA0107.1 | 0.814533 |
| MA0108.2 | 0.710846 |
| MA0109.1 | 0 |
| MA0111.1 | 0.415012 |
| MA0113.1 | 0.598933 |
| MA0114.1 | 0.222763 |
| MA0115.1 | 0.969632 |
| MA0116.1 | 0.27152 |
| MA0117.1 | 0.937363 |
| MA0119.1 | 0.951747 |
| MA0122.1 | 0.957212 |
| MA0124.1 | 1.16127 |
| MA0125.1 | 1.0872 |
| MA0130.1 | 0 |
| MA0131.1 | 1.63575 |
| MA0132.1 | 0 |
| MA0133.1 | 0 |
| MA0135.1 | 1.00325 |
| MA0136.1 | 0.550755 |
| MA0139.1 | 0.169849 |
| MA0140.1 | 0.519484 |
| MA0141.1 | 0.325895 |
| MA0142.1 | 0.761136 |
| MA0143.1 | 0.615203 |
| MA0144.1 | 0.225588 |
| MA0145.1 | 0.527241 |
| MA0146.1 | 1.31232 |
| MA0147.1 | 0.236889 |
| MA0148.1 | 0.450593 |
| MA0149.1 | 0.367458 |
| MA0062.2 | 0.426733 |
| MA0035.2 | 2.24059 |
| MA0039.2 | 0.812684 |
| MA0138.2 | 0.675599 |
| MA0002.2 | 0.172399 |
| MA0137.2 | 0.32312 |
| MA0104.2 | 0.18504 |
| MA0047.2 | 0.576767 |
| MA0112.2 | 0.2464 |
| MA0065.2 | 0.902537 |
| MA0150.1 | 0.419883 |
| MA0151.1 | 0 |
| MA0152.1 | 0.576873 |
| MA0153.1 | 1.01988 |
| MA0154.1 | 0.330759 |
| MA0155.1 | 6.39157 |
| MA0156.1 | 0.314185 |
| MA0157.1 | 0.729116 |
| MA0158.1 | 0 |
| MA0159.1 | 0.688775 |
| MA0160.1 | 0.453546 |
| MA0161.1 | 0 |
| MA0162.1 | 0.0925951 |
| MA0163.1 | 1.36861 |
| MA0164.1 | 0.551114 |
| MA0080.2 | 0.302064 |
| MA0018.2 | 0.560731 |
| MA0099.2 | 0.669311 |
| MA0079.2 | 1.00617 |
| MA0102.2 | 1.59466 |
| MA0258.1 | 0.210437 |
| MA0259.1 | 1.87317 |
| MA0442.1 | 0 |
