Coexpression cluster:C1696

Full id: C1696_Endothelial_Renal_chronic_Lymphatic_Fibroblast_Hepatic_Mesenchymal

Phase1 CAGE Peaks

Hg19::chr12:96830523..96830532,+	p@chr12:96830523..96830532 +
Hg19::chr17:8216873..8216875,+	p@chr17:8216873..8216875 +
Hg19::chr7:139741849..139741879,-	p12@PARP12
Hg19::chr9:139559213..139559241,+	p5@EGFL7
Hg19::chr9:139563124..139563129,+	p@chr9:139563124..139563129 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0001570	vasculogenesis	0.0370800874571462
GO:0003950	NAD+ ADP-ribosyltransferase activity	0.0391285678131703
GO:0016763	transferase activity, transferring pentosyl groups	0.0426519646402055
GO:0001525	angiogenesis	0.0426519646402055
GO:0048514	blood vessel morphogenesis	0.0426519646402055
GO:0048646	anatomical structure formation	0.0426519646402055
GO:0001568	blood vessel development	0.0426519646402055
GO:0001944	vasculature development	0.0426519646402055

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n
endothelial cell of vascular tree	2.23e-44	24
endothelial cell	6.13e-39	35
blood vessel endothelial cell	4.21e-34	18
embryonic blood vessel endothelial progenitor cell	4.21e-34	18
meso-epithelial cell	4.94e-31	44
mesodermal cell	8.05e-22	119
lining cell	1.07e-21	57
barrier cell	1.07e-21	57
endothelial cell of artery	7.31e-18	9
vein endothelial cell	1.41e-12	6
aortic endothelial cell	1.52e-12	6
lymphangioblast	9.28e-12	6
endothelial cell of lymphatic vessel	9.28e-12	6
vascular lymphangioblast	9.28e-12	6
vascular associated smooth muscle cell	5.51e-10	32
aortic smooth muscle cell	4.36e-08	10
endothelial cell of umbilical vein	4.87e-07	3
cardiocyte	5.74e-07	16
capillary endothelial cell	6.48e-07	3

Uber Anatomy

Ontology term	p-value	n
vessel	7.64e-46	69
splanchnic layer of lateral plate mesoderm	7.11e-41	84
vasculature	3.93e-40	79
vascular system	3.93e-40	79
blood vessel	2.34e-39	60
epithelial tube open at both ends	2.34e-39	60
blood vasculature	2.34e-39	60
vascular cord	2.34e-39	60
cardiovascular system	5.69e-36	110
circulatory system	1.49e-34	113
endothelium	4.21e-34	18
blood vessel endothelium	4.21e-34	18
cardiovascular system endothelium	4.21e-34	18
epithelial tube	1.13e-30	118
simple squamous epithelium	9.30e-27	22
artery	1.95e-26	42
arterial blood vessel	1.95e-26	42
arterial system	1.95e-26	42
squamous epithelium	3.05e-25	25
tube	1.40e-22	194
systemic artery	7.12e-21	33
systemic arterial system	7.12e-21	33
anatomical conduit	1.13e-20	241
aorta	4.02e-19	21
aortic system	4.02e-19	21
anatomical cluster	1.32e-18	286
endothelial tube	7.31e-18	9
arterial system endothelium	7.31e-18	9
endothelium of artery	7.31e-18	9
unilaminar epithelium	4.54e-14	138
epithelium	4.26e-13	309
cell layer	8.76e-13	312
lateral plate mesoderm	1.10e-12	216
heart	7.24e-09	24
primitive heart tube	7.24e-09	24
primary heart field	7.24e-09	24
anterior lateral plate mesoderm	7.24e-09	24
heart tube	7.24e-09	24
heart primordium	7.24e-09	24
cardiac mesoderm	7.24e-09	24
cardiogenic plate	7.24e-09	24
heart rudiment	7.24e-09	24
lymphoid system	8.54e-09	10
lymphatic vessel	1.50e-08	8
lymph vasculature	1.50e-08	8
lymphatic part of lymphoid system	1.50e-08	8
blood vessel smooth muscle	4.36e-08	10
arterial system smooth muscle	4.36e-08	10
artery smooth muscle tissue	4.36e-08	10
aorta smooth muscle tissue	4.36e-08	10
vein	5.34e-08	9
venous blood vessel	5.34e-08	9
venous system	5.34e-08	9
primary circulatory organ	1.53e-07	27
endothelium of capillary	6.48e-07	3
capillary	6.48e-07	3

Disease

Ontology term	p-value	n
chronic leukemia	2.09e-10	8

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.