MCL coexpression mm9:1189

Phase1 CAGE Peaks

	Short description
Mm9::chr2:58999674..58999693,+	p4@Pkp4
Mm9::chr4:101180704..101180735,+	p2@Dnajc6
Mm9::chr6:24903644..24903650,-	p@chr6:24903644..24903650 -
Mm9::chr6:24906071..24906105,-	p1@Tmem229a
Mm9::chr6:24906106..24906131,-	p2@Tmem229a
Mm9::chr6:24906348..24906371,-	p3@Tmem229a
Mm9::chr8:93657848..93657921,-	p1@Aktip

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0032092	positive regulation of protein binding	0.0226799604204372
GO:0043393	regulation of protein binding	0.0264527057129833
GO:0051099	positive regulation of binding	0.0264527057129833
GO:0051098	regulation of binding	0.0395726164332678
GO:0033240	positive regulation of amine metabolic process	0.0395726164332678
GO:0045764	positive regulation of amino acid metabolic process	0.0395726164332678
GO:0001934	positive regulation of protein amino acid phosphorylation	0.0395726164332678
GO:0006793	phosphorus metabolic process	0.0395726164332678
GO:0006796	phosphate metabolic process	0.0395726164332678
GO:0031072	heat shock protein binding	0.0395726164332678
GO:0001932	regulation of protein amino acid phosphorylation	0.0395726164332678
GO:0033238	regulation of amine metabolic process	0.0395726164332678
GO:0006521	regulation of amino acid metabolic process	0.0395726164332678
GO:0042325	regulation of phosphorylation	0.0395726164332678
GO:0051174	regulation of phosphorus metabolic process	0.0395726164332678
GO:0019220	regulation of phosphate metabolic process	0.0395726164332678

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
ecto-epithelium	3.55e-22	73
ectoderm-derived structure	6.22e-22	95
ectoderm	6.22e-22	95
presumptive ectoderm	6.22e-22	95
neurectoderm	5.40e-20	64
neural plate	5.40e-20	64
presumptive neural plate	5.40e-20	64
regional part of nervous system	1.13e-18	54
central nervous system	1.66e-17	73
nervous system	2.56e-17	75
neural tube	3.76e-17	52
neural rod	3.76e-17	52
future spinal cord	3.76e-17	52
neural keel	3.76e-17	52
pre-chordal neural plate	7.59e-16	49
brain	2.69e-14	47
future brain	2.69e-14	47
regional part of brain	1.28e-13	46
structure with developmental contribution from neural crest	4.83e-13	92
anterior neural tube	1.41e-12	40
gray matter	1.55e-12	34
regional part of forebrain	6.43e-12	39
forebrain	6.43e-12	39
future forebrain	6.43e-12	39
brain grey matter	8.74e-10	29
regional part of telencephalon	8.74e-10	29
telencephalon	8.74e-10	29
cavitated compound organ	2.60e-07	21
regional part of cerebral cortex	2.96e-07	17
occipital lobe	3.89e-07	10
visual cortex	3.89e-07	10
neocortex	3.89e-07	10

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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