MCL coexpression mm9:1661

Phase1 CAGE Peaks

	Short description
Mm9::chr14:122873999..122874022,+	p@chr14:122873999..122874022 +
Mm9::chr14:122874619..122874634,+	p1@Zic2
Mm9::chr14:122874718..122874729,+	p3@Zic2
Mm9::chr9:91260797..91260807,+	p@chr9:91260797..91260807 +
Mm9::chr9:91263649..91263666,+	p3@Zic4

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0048066	pigmentation during development	0.0408015330915254
GO:0001843	neural tube closure	0.0408015330915254
GO:0014020	primary neural tube formation	0.0408015330915254
GO:0001841	neural tube formation	0.0408015330915254
GO:0001839	neural plate morphogenesis	0.0408015330915254
GO:0001838	embryonic epithelial tube formation	0.0408015330915254
GO:0001840	neural plate development	0.0408015330915254
GO:0021915	neural tube development	0.0408015330915254
GO:0016331	morphogenesis of embryonic epithelium	0.0408015330915254
GO:0008270	zinc ion binding	0.0427512187222919
GO:0003677	DNA binding	0.0427512187222919

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
neural cell	1.23e-14	43
CNS neuron (sensu Vertebrata)	3.45e-14	23
neuroblast (sensu Vertebrata)	3.45e-14	23
ectodermal cell	5.06e-14	44
neurectodermal cell	5.06e-14	44
non-terminally differentiated cell	4.40e-12	49
neuron	1.28e-08	33
neuronal stem cell	1.28e-08	33
neuroblast	1.28e-08	33
electrically signaling cell	1.28e-08	33
oligodendrocyte precursor cell	3.97e-08	8
migratory neural crest cell	5.87e-08	10
neuron associated cell	5.87e-08	10
glial cell (sensu Vertebrata)	5.87e-08	10
neuron associated cell (sensu Vertebrata)	5.87e-08	10
glial cell	5.87e-08	10
glioblast	5.87e-08	10
glioblast (sensu Vertebrata)	5.87e-08	10

Uber Anatomy

Ontology term	p-value	n
nervous system	3.66e-32	75
central nervous system	8.75e-32	73
regional part of nervous system	2.00e-30	54
neurectoderm	4.65e-30	64
neural plate	4.65e-30	64
presumptive neural plate	4.65e-30	64
ectoderm-derived structure	1.52e-29	95
ectoderm	1.52e-29	95
presumptive ectoderm	1.52e-29	95
neural tube	2.24e-28	52
neural rod	2.24e-28	52
future spinal cord	2.24e-28	52
neural keel	2.24e-28	52
ecto-epithelium	3.67e-25	73
brain	3.76e-25	47
future brain	3.76e-25	47
regional part of brain	3.08e-24	46
pre-chordal neural plate	1.50e-23	49
anterior neural tube	1.22e-19	40
regional part of forebrain	2.57e-19	39
forebrain	2.57e-19	39
future forebrain	2.57e-19	39
gray matter	1.99e-16	34
structure with developmental contribution from neural crest	1.08e-15	92
brain grey matter	3.93e-13	29
regional part of telencephalon	3.93e-13	29
telencephalon	3.93e-13	29
posterior neural tube	2.86e-09	12
chordal neural plate	2.86e-09	12
cerebral cortex	1.37e-07	21
cerebral hemisphere	1.37e-07	21
pallium	1.37e-07	21
basal ganglion	1.99e-07	8
nuclear complex of neuraxis	1.99e-07	8
aggregate regional part of brain	1.99e-07	8
collection of basal ganglia	1.99e-07	8
cerebral subcortex	1.99e-07	8
diencephalon	2.63e-07	10
future diencephalon	2.63e-07	10

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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