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{{Coexpression_clusters
{
|coexpression_dpi_cluster_scores_median=0,0

Latest revision as of 11:37, 17 September 2013


Full id: C1071_renal_serous_Olfactory_clear_mesothelioma_Fibroblast_mesenchymal



Phase1 CAGE Peaks

Hg19::chr20:9049682..9049710,+p3@PLCB4
Hg19::chr20:9049723..9049741,+p2@PLCB4
Hg19::chr20:9049742..9049765,+p5@PLCB4
Hg19::chr20:9049766..9049777,+p9@PLCB4
Hg19::chr20:9049782..9049807,+p6@PLCB4
Hg19::chr20:9077899..9077903,+p@chr20:9077899..9077903
+
Hg19::chr20:9079545..9079556,+p@chr20:9079545..9079556
+
Hg19::chr20:9172019..9172022,+p@chr20:9172019..9172022
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
skin fibroblast2.61e-0723
Uber Anatomy
Ontology termp-valuen
adult organism3.28e-16114
multi-tissue structure1.43e-13342
organ system subdivision1.43e-12223
ectoderm-derived structure3.66e-12171
ectoderm3.66e-12171
presumptive ectoderm3.66e-12171
anatomical cluster2.91e-11373
central nervous system1.59e-1081
nervous system2.77e-1089
organ3.66e-10503
structure with developmental contribution from neural crest5.16e-10132
neural tube1.12e-0956
neural rod1.12e-0956
future spinal cord1.12e-0956
neural keel1.12e-0956
organ part4.55e-09218
neural plate6.28e-0982
presumptive neural plate6.28e-0982
regional part of nervous system9.78e-0953
regional part of brain9.78e-0953
brain1.70e-0868
future brain1.70e-0868
neurectoderm2.59e-0886
cavitated compound organ3.73e-0831
ecto-epithelium3.94e-08104
multi-cellular organism9.91e-08656
kidney2.20e-0726
kidney mesenchyme2.20e-0726
upper urinary tract2.20e-0726
kidney rudiment2.20e-0726
kidney field2.20e-0726
anatomical system3.03e-07624
anatomical group3.86e-07625
digestive system4.49e-07145
digestive tract4.49e-07145
primitive gut4.49e-07145
surface structure4.99e-0799


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.11.66566
MA0004.10.455723
MA0006.14.06209
MA0007.10.437331
MA0009.10.918715
MA0014.12.22106
MA0017.10.337901
MA0019.10.602411
MA0024.10.813542
MA0025.11.05265
MA0027.12.5321
MA0028.10.846854
MA0029.10.832916
MA0030.10.821423
MA0031.10.756713
MA0038.10.557409
MA0040.10.838784
MA0041.10.474018
MA0042.10.442535
MA0043.10.919032
MA0046.10.90778
MA0048.10.0955945
MA0050.10.443405
MA0051.10.553205
MA0052.10.842664
MA0055.11.2107
MA0056.10
MA0057.12.77978
MA0058.10.362328
MA0059.10.361075
MA0060.10.190336
MA0061.10.165998
MA0063.10
MA0066.10.557833
MA0067.11.23721
MA0068.11.33409
MA0069.10.903908
MA0070.10.892666
MA0071.10.518907
MA0072.10.888148
MA0073.10.634172
MA0074.10.552456
MA0076.10.377799
MA0077.10.880402
MA0078.10.652193
MA0081.10.361233
MA0083.10.926258
MA0084.11.42483
MA0087.10.885691
MA0088.10.770971
MA0089.10
MA0090.10.391903
MA0091.10.458301
MA0092.10.421159
MA0093.10.303084
MA0095.10
MA0098.10
MA0100.10.571227
MA0101.10.30624
MA0103.10.291333
MA0105.12.02572
MA0106.10.59853
MA0107.10.666147
MA0108.22.97762
MA0109.10
MA0111.10.405141
MA0113.10.614917
MA0114.10.231781
MA0115.11.1606
MA0116.10.239768
MA0117.10.956472
MA0119.10.913661
MA0122.10.982472
MA0124.11.11898
MA0125.11.0347
MA0130.10
MA0131.10.670358
MA0132.10
MA0133.10
MA0135.10.949204
MA0136.10.564434
MA0139.10.470675
MA0140.10.516266
MA0141.10.359385
MA0142.10.724856
MA0143.10.615094
MA0144.10.218541
MA0145.10.480646
MA0146.11.26525
MA0147.10.243042
MA0148.10.480298
MA0149.10.506665
MA0062.20.161302
MA0035.20.515566
MA0039.21.1556
MA0138.20.653421
MA0002.20.179788
MA0137.20.321796
MA0104.21.05746
MA0047.20.586412
MA0112.20.458158
MA0065.20.0631316
MA0150.10.386144
MA0151.10
MA0152.10.52279
MA0153.11.01778
MA0154.10.0799828
MA0155.10.0535085
MA0156.10.323987
MA0157.10.697424
MA0158.10
MA0159.10.243637
MA0160.11.23953
MA0161.10
MA0162.11.29519
MA0163.11.06699
MA0164.10.627336
MA0080.20.303167
MA0018.20.599912
MA0099.20.523145
MA0079.27.23496
MA0102.21.46209
MA0258.10.209744
MA0259.10.25092
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
E2F1#186953.067118259299580.01129732364974160.0414429639850847
FOXA1#316945.540709874692730.003444272925946160.0175232083063567
GATA3#2625310.21369363395230.002410870126189130.013590374324449
MYC#460953.263926169755880.008583639497943430.0327034410304142
NR3C1#290859.358139581983156.26414306316282e-050.00102494256207686



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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