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{{Coexpression_clusters
{
|full_id=C1826_Neutrophils_parietal_lung_occipital_cerebellum_temporal_CD4
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Latest revision as of 11:53, 17 September 2013


Full id: C1826_Neutrophils_parietal_lung_occipital_cerebellum_temporal_CD4



Phase1 CAGE Peaks

Hg19::chr19:53606636..53606692,-p1@ZNF160
Hg19::chr2:37311445..37311534,-p1@HEATR5B
Hg19::chr3:101232019..101232063,-p1@SENP7
Hg19::chr5:93447333..93447386,-p1@FAM172A
Hg19::chr6:111804393..111804436,-p2@REV3L


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0016035zeta DNA polymerase complex0.00447427293064877
GO:0003894zeta DNA polymerase activity0.00447427293064877
GO:0042575DNA polymerase complex0.00671081671889418
GO:0016925protein sumoylation0.00671081671889418



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
adult organism3.59e-33114
neural tube3.99e-1756
neural rod3.99e-1756
future spinal cord3.99e-1756
neural keel3.99e-1756
regional part of nervous system7.87e-1653
regional part of brain7.87e-1653
central nervous system2.85e-1581
regional part of forebrain1.32e-1441
forebrain1.32e-1441
anterior neural tube1.32e-1441
future forebrain1.32e-1441
nervous system2.47e-1489
brain3.31e-1468
future brain3.31e-1468
telencephalon5.77e-1234
brain grey matter6.82e-1234
gray matter6.82e-1234
regional part of telencephalon3.09e-1132
cerebral hemisphere4.84e-1132
regional part of cerebral cortex1.33e-0922
neurectoderm1.99e-0986
neocortex4.22e-0920
cerebral cortex6.67e-0925
pallium6.67e-0925
neural plate7.22e-0982
presumptive neural plate7.22e-0982


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.737422
MA0004.10.626788
MA0006.10.452993
MA0007.10.606704
MA0009.11.11255
MA0014.11.02528
MA0017.10.496101
MA0019.10.784036
MA0024.11.00439
MA0025.11.24931
MA0027.12.73598
MA0028.13.05902
MA0029.11.02437
MA0030.11.01252
MA0031.10.945567
MA0038.10.736268
MA0040.11.03042
MA0041.10.64667
MA0042.10.612397
MA0043.11.11288
MA0046.11.10134
MA0048.10.569896
MA0050.10.613347
MA0051.10.731787
MA0052.11.03442
MA0055.11.01397
MA0056.10
MA0057.11.66737
MA0058.10.523638
MA0059.11.29682
MA0060.10.321781
MA0061.10.291022
MA0063.10
MA0066.10.736721
MA0067.11.43651
MA0068.10.692739
MA0069.11.09737
MA0070.11.08584
MA0071.10.695094
MA0072.11.0812
MA0073.10.362215
MA0074.10.730989
MA0076.14.54816
MA0077.11.07324
MA0078.10.836493
MA0081.10.522409
MA0083.11.12028
MA0084.11.62584
MA0087.11.07867
MA0088.10.818263
MA0089.10
MA0090.10.556637
MA0091.10.629594
MA0092.10.588959
MA0093.10.456342
MA0095.10
MA0098.10
MA0100.10.750974
MA0101.10.459973
MA0103.10.442769
MA0105.10.175503
MA0106.10.779931
MA0107.10.378225
MA0108.20.94238
MA0109.10
MA0111.10.5713
MA0113.10.797251
MA0114.10.372523
MA0115.11.35895
MA0116.10.382106
MA0117.11.1512
MA0119.10.504689
MA0122.11.17777
MA0124.11.31673
MA0125.11.23103
MA0130.10
MA0131.10.855546
MA0132.10
MA0133.10
MA0135.11.14377
MA0136.10.743749
MA0139.10.277033
MA0140.10.692258
MA0141.10.520334
MA0142.10.912455
MA0143.10.797437
MA0144.10.356507
MA0145.10.442008
MA0146.10.0359558
MA0147.11.00307
MA0148.10.653474
MA0149.10.681935
MA0062.24.92942
MA0035.20.691506
MA0039.21.92202
MA0138.20.837782
MA0002.20.83106
MA0137.20.47779
MA0104.20.858845
MA0047.20.767096
MA0112.20.136971
MA0065.20.449243
MA0150.10.550239
MA0151.10
MA0152.10.69926
MA0153.11.21379
MA0154.10.98952
MA0155.10.130813
MA0156.13.10266
MA0157.10.883854
MA0158.10
MA0159.10.386729
MA0160.10.669748
MA0161.10
MA0162.10.81299
MA0163.10.382496
MA0164.10.810347
MA0080.20.456437
MA0018.20.781393
MA0099.20.699641
MA0079.24.3662
MA0102.23.62459
MA0258.10.345771
MA0259.10.395396
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CEBPB#105146.376918100659850.001113944176677320.00765389578078962
E2F6#187644.013724585357910.006632118233933880.0282992235754952
EGR1#195843.990543275848110.0067800983001440.0287684523591752
ELF1#199754.258097958807540.0007142416939776840.00573408319450652
ELK4#2005412.98854532677446.83810524411663e-050.00109099430734845
ETS1#211347.783008737761870.0005121035947688870.00444105184207156
GABPB1#255357.067683836182175.6685482528729e-050.000948593992920674
HEY1#2346254.040111043105710.0009288852205177990.00674489630436337
MYC#460944.177825497287520.005691969036823440.0256843186103609
NR2C2#7182213.04584436209630.00883636412768260.0335476038071556
POU2F2#545235.463674434645510.01115650094469780.0410142490817448
REST#597835.790017229676810.009468788694433940.0357020405956167
SIN3A#2594255.408884726815140.0002159522671657270.00248171642061195
TAF1#687253.343046285745290.002394600090870310.013542515778979
ZBTB33#10009212.66589001199250.009357016059651590.0353405685033253



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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