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MCL coexpression mm9:2693: Difference between revisions

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{{MCL_coexpression_mm9
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and calmodulin-dependent protein kinase complex;0.0378231262427327;12323!GO:0004683;calmodulin-dependent protein kinase activity;0.0378231262427327;12323!GO:0000082;G1/S transition of mitotic cell cycle;0.0378231262427327;12323!GO:0046777;protein amino acid autophosphorylation;0.0378231262427327;12323!GO:0016540;protein autoprocessing;0.0378231262427327;12323!GO:0051325;interphase;0.0378231262427327;12323!GO:0051329;interphase of mitotic cell cycle;0.0378231262427327;12323!|ontology_enrichment_celltype=CL:0000117!7.10e-10!23;CL:0000337!7.10e-10!23|ontology_enrichment_disease=|ontology_enrichment_uberon=UBERON:0000073!1.86e-18!54;UBERON:0001049!7.59e-18!52;UBERON:0005068!7.59e-18!52;UBERON:0006241!7.59e-18!52;UBERON:0007135!7.59e-18!52;UBERON:0000955!1.34e-17!47;UBERON:0006238!1.34e-17!47;UBERON:0002020!9.97e-17!34;UBERON:0003528!1.43e-16!29;UBERON:0002791!1.43e-16!29;UBERON:0001893!1.43e-16!29;UBERON:0003080!2.44e-16!40;UBERON:0002616!2.60e-16!46;UBERON:0002780!2.04e-15!39;UBERON:0001890!2.04e-15!39;UBERON:0006240!2.04e-15!39;UBERON:0002346!2.27e-15!64;UBERON:0003075!2.27e-15!64;UBERON:0007284!2.27e-15!64;UBERON:0001017!3.69e-15!73;UBERON:0003056!1.12e-14!49;UBERON:0001016!1.60e-14!75;UBERON:0010371!1.79e-12!73;UBERON:0004121!2.29e-11!95;UBERON:0000924!2.29e-11!95;UBERON:0006601!2.29e-11!95;UBERON:0000956!4.06e-11!21;UBERON:0001869!4.06e-11!21;UBERON:0000203!4.06e-11!21;UBERON:0000369!2.36e-08!5;UBERON:0002435!2.36e-08!5;UBERON:0000204!2.36e-08!5;UBERON:0010082!2.36e-08!5;UBERON:0010314!2.74e-08!92;UBERON:0002619!7.60e-07!17;UBERON:0002420!8.42e-07!8;UBERON:0007245!8.42e-07!8;UBERON:0010009!8.42e-07!8;UBERON:0010011!8.42e-07!8;UBERON:0000454!8.42e-07!8|tfbs_overrepresentation_for_novel_motifs=0.752782,0.193418,0.722405,0.801166,0.587814,0.81763,0.919454,0.467321,0.479531,0.235304,0.870507,0.906098,0.467629,0.933025,0.608226,0,1.14208,0.578045,0.448066,0.328717,0.679146,0.275782,0.932027,0.585919,0.731217,0.963352,1.95122,0.841386,0.64294,0.380786,0.825437,1.24901,0.575271,1.05917,0.608816,0.144706,0.563758,0.902078,0.536514,0.50014,0.582863,0.831295,0.724277,0.610669,0.156582,1.85291,1.05665,0.859154,0.235354,0.646474,1.12346,0.99279,0.371606,1.3966,1.41464,0.940919,0.657156,0.891887,0.425455,0.938668,1.22795,1.00308,0.494668,1.11142,0.953187,1.15459,1.55483,1.90983,1.22303,1.7608,0.700291,0.474956,0.284975,1.44925,0.416814,3.74616,0.411601,1.04436,1.20986,0.684144,2.08293,1.16055,1.00151,0.459035,1.32978,0.181575,1.07971,0.380977,1.06194,2.07346,1.62608,1.33496,1.26245,0.595071,0.531443,1.26911,1.17262,1.26539,1.05692,0.352122,0.563856,1.24872,1.37854,1.12409,1.12297,0.830796,1.18646,0.854628,0.689894,0.681267,0.744607,1.38039,0.685481,0.876299,1.63327,0.580657,0.212464,0.805461,1.14346,0.559153,1.45481,1.08896,0.965352,1.04338,1.68841,1.21376,0.928483,1.25534,1.55328,0.598722,1.36093,0.792832,1.52297,0.955954,1.65529,0.273451,0.762499,0.832891,1.60513,2.44352,2.04137,1.55966,0.978551,1.26,1.11604,0.831808,1.06002,2.40374,0.765221,0.589976,0.38417,0.260379,1.39822,0.516739,0.954936,1.48249,0.993889,0.622823,0.749933,0.762177,1.61484,1.32889,1.21423,5.64789,1.11251,0.94678,0.562367,0.904334,0.135528|tfbs_overrepresentation_jaspar=MA0003.1;0.0699972,MA0004.1;0.801718,MA0006.1;0.60285,MA0007.1;0.784593,MA0009.1;1.27673,MA0014.1;0.133574,MA0017.1;0.635031,MA0019.1;1.08369,MA0024.1;1.23079,MA0025.1;1.51835,MA0027.1;2.9431,MA0028.1;0.61552,MA0029.1;1.20789,MA0030.1;1.21482,MA0031.1;1.17722,MA0038.1;0.963265,MA0040.1;1.28983,MA0041.1;0.714279,MA0042.1;0.69885,MA0043.1;1.3775,MA0046.1;1.31428,MA0048.1;0.353763,MA0050.1;0.845669,MA0051.1;0.973068,MA0052.1;1.29825,MA0055.1;0.557057,MA0056.1;0,MA0057.1;0.896032,MA0058.1;0.690848,MA0059.1;0.705317,MA0060.1;1.25521,MA0061.1;0.5406,MA0063.1;0,MA0066.1;0.951196,MA0067.1;1.63197,MA0068.1;0.908538,MA0069.1;1.29861,MA0070.1;1.28847,MA0071.1;0.844726,MA0072.1;1.2796,MA0073.1;0.0430758,MA0074.1;0.911576,MA0076.1;0.657929,MA0077.1;1.2569,MA0078.1;1.0091,MA0081.1;0.732313,MA0083.1;1.37668,MA0084.1;1.96428,MA0087.1;1.33189,MA0088.1;0.27999,MA0089.1;0,MA0090.1;0.762482,MA0091.1;0.816659,MA0092.1;0.762845,MA0093.1;0.62555,MA0095.1;0,MA0098.1;0,MA0100.1;0.89873,MA0101.1;0.71579,MA0103.1;0.647985,MA0105.1;0.405648,MA0106.1;1.01755,MA0107.1;0.640607,MA0108.2;1.10817,MA0109.1;0,MA0111.1;0.778753,MA0113.1;0.986839,MA0114.1;0.537669,MA0115.1;1.38041,MA0116.1;1.46662,MA0117.1;1.34691,MA0119.1;0.716476,MA0122.1;1.36752,MA0124.1;1.57762,MA0125.1;1.5017,MA0130.1;0,MA0131.1;1.07881,MA0132.1;0,MA0133.1;0,MA0135.1;1.4152,MA0136.1;0.933582,MA0139.1;0.462282,MA0140.1;0.898603,MA0141.1;0.671467,MA0142.1;1.16183,MA0143.1;1.00467,MA0144.1;0.541532,MA0145.1;0.292366,MA0146.1;0.151124,MA0147.1;0.556853,MA0148.1;0.820161,MA0149.1;0.722227,MA0062.2;0.412742,MA0035.2;0.903829,MA0039.2;0.0481552,MA0138.2;1.07027,MA0002.2;0.466067,MA0137.2;0.668025,MA0104.2;0.48458,MA0047.2;0.962424,MA0112.2;0.29236,MA0065.2;0.292912,MA0150.1;0.784464,MA0151.1;0,MA0152.1;0.962542,MA0153.1;1.43238,MA0154.1;0.35067,MA0155.1;0.312898,MA0156.1;0.656895,MA0157.1;1.12772,MA0158.1;0,MA0159.1;1.39671,MA0160.1;0.823568,MA0161.1;0,MA0162.1;0.166722,MA0163.1;0.927936,MA0164.1;0.933981,MA0080.2;0.64167,MA0018.2;0.944669,MA0099.2;1.06348,MA0079.2;0.00937321,MA0102.2;2.01714,MA0258.1;0.520639,MA0259.1;0.543506,MA0442.1;0}}
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|coexpression_dpi_cluster_scores_median=0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0354470656487682,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.147562843172839,0,0,0,0,0,0,0,0,0,0.0818436986734574,0.187527419446322,0.0829019901297716,0,0.0866689030825281,0.0501827898833331,0.0397493170902889,0,0,0.052188704109448,0.164596587144155,0.101668926708099,0.0380188235580625,0.182104477852721,0,0,0.0617533076901792,0,0.108816382318513,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0825867363219064,0,0,0,0,0.0606187686764715,0.163608743054207,0.2440112939716,0.129576677486723,0.247272523425973,0.0819907263755358,0.257967923814717,0,0,0,0,0,0,0,0,0.0285860945550467,0,0.107584785071413,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.428510521188536,0.708946197219859,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.120936080462619,0,0,0,0,0,0,0,0,0,0,0,0,0.590160763107643,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0712812415377886,0,0,0,0,0,0,0,0,0,0,0,0.0738741926906438,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.194445471641185,0.376754964798171,0.196699873644339,0.307735388878776,0,0,0,0.161464196262218,0,0,0,0,0,0,0,0,0.159715578577694,0.149856261570464,0.120876255993453,0,0,0,0.0388749848471105,0.120615306320652,0.0898139621139603,0,0.198498081255604,0.0766073954291401,0.14986111676545,0.0596387295197733,0,0.0709519923534245,0,0.0589368614163519,0.0748964051866952,0.0352754493378881,0.0729583017401753,0,0.0553034373508932,0,0.0924644954689594,0.0780974029773103,0.148982201447044,0.117229416500102,0.0766064454112358,0.175981558593572,0,0.0845301845292944,0,0,0
|gostat_on_MCL_coexpression=GO:0005954;calcium- and calmodulin-dependent protein kinase complex;0.0378231262427327;12323!GO:0004683;calmodulin-dependent protein kinase activity;0.0378231262427327;12323!GO:0000082;G1/S transition of mitotic cell cycle;0.0378231262427327;12323!GO:0046777;protein amino acid autophosphorylation;0.0378231262427327;12323!GO:0016540;protein autoprocessing;0.0378231262427327;12323!GO:0051325;interphase;0.0378231262427327;12323!GO:0051329;interphase of mitotic cell cycle;0.0378231262427327;12323!
}}

Latest revision as of 18:56, 17 September 2013


Phase1 CAGE Peaks

 Short description
Mm9::chr11:5966113..5966123,-p17@Camk2b
Mm9::chr11:5966124..5966140,-p13@Camk2b
Mm9::chr3:117277800..117277823,+p5@4833424O15Rik


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0005954calcium- and calmodulin-dependent protein kinase complex0.0378231262427327
GO:0004683calmodulin-dependent protein kinase activity0.0378231262427327
GO:0000082G1/S transition of mitotic cell cycle0.0378231262427327
GO:0046777protein amino acid autophosphorylation0.0378231262427327
GO:0016540protein autoprocessing0.0378231262427327
GO:0051325interphase0.0378231262427327
GO:0051329interphase of mitotic cell cycle0.0378231262427327



Relative expression of the co-expression cluster over median <br>Analyst:




Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
CNS neuron (sensu Vertebrata)7.10e-1023
neuroblast (sensu Vertebrata)7.10e-1023

Uber Anatomy
Ontology termp-valuen
regional part of nervous system1.86e-1854
neural tube7.59e-1852
neural rod7.59e-1852
future spinal cord7.59e-1852
neural keel7.59e-1852
brain1.34e-1747
future brain1.34e-1747
gray matter9.97e-1734
brain grey matter1.43e-1629
regional part of telencephalon1.43e-1629
telencephalon1.43e-1629
anterior neural tube2.44e-1640
regional part of brain2.60e-1646
regional part of forebrain2.04e-1539
forebrain2.04e-1539
future forebrain2.04e-1539
neurectoderm2.27e-1564
neural plate2.27e-1564
presumptive neural plate2.27e-1564
central nervous system3.69e-1573
pre-chordal neural plate1.12e-1449
nervous system1.60e-1475
ecto-epithelium1.79e-1273
ectoderm-derived structure2.29e-1195
ectoderm2.29e-1195
presumptive ectoderm2.29e-1195
cerebral cortex4.06e-1121
cerebral hemisphere4.06e-1121
pallium4.06e-1121
corpus striatum2.36e-085
striatum2.36e-085
ventral part of telencephalon2.36e-085
future corpus striatum2.36e-085
structure with developmental contribution from neural crest2.74e-0892
regional part of cerebral cortex7.60e-0717
basal ganglion8.42e-078
nuclear complex of neuraxis8.42e-078
aggregate regional part of brain8.42e-078
collection of basal ganglia8.42e-078
cerebral subcortex8.42e-078


TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs




JASPAR motifs


Motifs-log10(p-value)
MA0003.10.0699972
MA0004.10.801718
MA0006.10.60285
MA0007.10.784593
MA0009.11.27673
MA0014.10.133574
MA0017.10.635031
MA0019.11.08369
MA0024.11.23079
MA0025.11.51835
MA0027.12.9431
MA0028.10.61552
MA0029.11.20789
MA0030.11.21482
MA0031.11.17722
MA0038.10.963265
MA0040.11.28983
MA0041.10.714279
MA0042.10.69885
MA0043.11.3775
MA0046.11.31428
MA0048.10.353763
MA0050.10.845669
MA0051.10.973068
MA0052.11.29825
MA0055.10.557057
MA0056.10
MA0057.10.896032
MA0058.10.690848
MA0059.10.705317
MA0060.11.25521
MA0061.10.5406
MA0063.10
MA0066.10.951196
MA0067.11.63197
MA0068.10.908538
MA0069.11.29861
MA0070.11.28847
MA0071.10.844726
MA0072.11.2796
MA0073.10.0430758
MA0074.10.911576
MA0076.10.657929
MA0077.11.2569
MA0078.11.0091
MA0081.10.732313
MA0083.11.37668
MA0084.11.96428
MA0087.11.33189
MA0088.10.27999
MA0089.10
MA0090.10.762482
MA0091.10.816659
MA0092.10.762845
MA0093.10.62555
MA0095.10
MA0098.10
MA0100.10.89873
MA0101.10.71579
MA0103.10.647985
MA0105.10.405648
MA0106.11.01755
MA0107.10.640607
MA0108.21.10817
MA0109.10
MA0111.10.778753
MA0113.10.986839
MA0114.10.537669
MA0115.11.38041
MA0116.11.46662
MA0117.11.34691
MA0119.10.716476
MA0122.11.36752
MA0124.11.57762
MA0125.11.5017
MA0130.10
MA0131.11.07881
MA0132.10
MA0133.10
MA0135.11.4152
MA0136.10.933582
MA0139.10.462282
MA0140.10.898603
MA0141.10.671467
MA0142.11.16183
MA0143.11.00467
MA0144.10.541532
MA0145.10.292366
MA0146.10.151124
MA0147.10.556853
MA0148.10.820161
MA0149.10.722227
MA0062.20.412742
MA0035.20.903829
MA0039.20.0481552
MA0138.21.07027
MA0002.20.466067
MA0137.20.668025
MA0104.20.48458
MA0047.20.962424
MA0112.20.29236
MA0065.20.292912
MA0150.10.784464
MA0151.10
MA0152.10.962542
MA0153.11.43238
MA0154.10.35067
MA0155.10.312898
MA0156.10.656895
MA0157.11.12772
MA0158.10
MA0159.11.39671
MA0160.10.823568
MA0161.10
MA0162.10.166722
MA0163.10.927936
MA0164.10.933981
MA0080.20.64167
MA0018.20.944669
MA0099.21.06348
MA0079.20.00937321
MA0102.22.01714
MA0258.10.520639
MA0259.10.543506
MA0442.10
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