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MCL coexpression mm9:3219: Difference between revisions

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{{MCL_coexpression_mm9
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IV activity;0.011527492729213;74388!GO:0008239;dipeptidyl-peptidase activity;0.011527492729213;74388!GO:0016806;dipeptidyl-peptidase and tripeptidyl-peptidase activity;0.011527492729213;74388!GO:0008233;peptidase activity;0.011527492729213;170822,74388!GO:0004177;aminopeptidase activity;0.0283509095421994;74388!GO:0004221;ubiquitin thiolesterase activity;0.0325375515202056;170822!GO:0004843;ubiquitin-specific protease activity;0.0325375515202056;170822!GO:0019783;small conjugating protein-specific protease activity;0.0325375515202056;170822!GO:0016790;thiolester hydrolase activity;0.0359570282017172;170822!GO:0008238;exopeptidase activity;0.0359570282017172;74388!GO:0016787;hydrolase activity;0.0394152488012717;170822,74388!GO:0008234;cysteine-type peptidase activity;0.0429744633852751;170822!GO:0004252;serine-type endopeptidase activity;0.0429744633852751;74388!GO:0044267;cellular protein metabolic process;0.0429744633852751;170822,74388!GO:0044260;cellular macromolecule metabolic process;0.0429744633852751;170822,74388!GO:0008236;serine-type peptidase activity;0.0429744633852751;74388!GO:0017171;serine hydrolase activity;0.0429744633852751;74388!GO:0019538;protein metabolic 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|gostat_on_MCL_coexpression=GO:0004274;dipeptidyl-peptidase IV activity;0.011527492729213;74388!GO:0008239;dipeptidyl-peptidase activity;0.011527492729213;74388!GO:0016806;dipeptidyl-peptidase and tripeptidyl-peptidase activity;0.011527492729213;74388!GO:0008233;peptidase activity;0.011527492729213;170822,74388!GO:0004177;aminopeptidase activity;0.0283509095421994;74388!GO:0004221;ubiquitin thiolesterase activity;0.0325375515202056;170822!GO:0004843;ubiquitin-specific protease activity;0.0325375515202056;170822!GO:0019783;small conjugating protein-specific protease activity;0.0325375515202056;170822!GO:0016790;thiolester hydrolase activity;0.0359570282017172;170822!GO:0008238;exopeptidase activity;0.0359570282017172;74388!GO:0016787;hydrolase activity;0.0394152488012717;170822,74388!GO:0008234;cysteine-type peptidase activity;0.0429744633852751;170822!GO:0004252;serine-type endopeptidase activity;0.0429744633852751;74388!GO:0044267;cellular protein metabolic process;0.0429744633852751;170822,74388!GO:0044260;cellular macromolecule metabolic process;0.0429744633852751;170822,74388!GO:0008236;serine-type peptidase activity;0.0429744633852751;74388!GO:0017171;serine hydrolase activity;0.0429744633852751;74388!GO:0019538;protein metabolic process;0.0429744633852751;170822,74388!
|ontology_enrichment_celltype=CL:0000117!2.51e-07!23;CL:0000337!2.51e-07!23
|ontology_enrichment_disease=
|ontology_enrichment_uberon=UBERON:0000073!1.04e-11!54;UBERON:0002020!1.28e-11!34;UBERON:0001049!1.21e-10!52;UBERON:0005068!1.21e-10!52;UBERON:0006241!1.21e-10!52;UBERON:0007135!1.21e-10!52;UBERON:0003528!1.96e-09!29;UBERON:0002791!1.96e-09!29;UBERON:0001893!1.96e-09!29;UBERON:0001017!4.35e-09!73;UBERON:0002346!8.36e-09!64;UBERON:0003075!8.36e-09!64;UBERON:0007284!8.36e-09!64;UBERON:0001016!9.69e-09!75;UBERON:0000955!1.28e-08!47;UBERON:0006238!1.28e-08!47;UBERON:0010371!1.44e-08!73;UBERON:0004121!2.32e-08!95;UBERON:0000924!2.32e-08!95;UBERON:0006601!2.32e-08!95;UBERON:0002616!3.47e-08!46;UBERON:0002021!5.94e-08!10;UBERON:0000411!5.94e-08!10;UBERON:0001950!5.94e-08!10;UBERON:0003080!8.36e-08!40;UBERON:0011216!1.14e-07!194;UBERON:0002780!2.25e-07!39;UBERON:0001890!2.25e-07!39;UBERON:0006240!2.25e-07!39;UBERON:0003056!3.68e-07!49
|tfbs_overrepresentation_for_novel_motifs=0.752782,0.193418,0.722405,0.801166,0.587814,0.81763,0.919454,0.467321,0.479531,0.66329,0.870507,0.906098,0.467629,0.933025,0.608226,0,1.14208,0.578045,0.448066,0.876292,0.679146,0.756749,0.932027,0.585919,0.731217,0.963352,0.437236,0.841386,0.64294,0.380786,0.825437,1.24901,1.40911,0.411696,0.608816,0.144706,0.563758,0.902078,0.536514,0.50014,0.582863,0.831295,0.261619,0.610669,0.922882,0.788421,1.05665,0.859154,0.235354,0.646474,1.12346,0.99279,0.371606,1.3966,1.41464,0.940919,0.657156,0.891887,0.425455,0.938668,1.22795,1.00308,0.494668,1.11142,0.953187,1.15459,1.55483,1.90983,1.22303,1.7608,1.6706,0.474956,0.284975,1.44925,1.07031,0.402065,0.411601,1.04436,1.20986,0.684144,0.476502,1.16055,1.00151,0.459035,1.32978,0.535545,0.195254,0.380977,1.06194,2.07346,1.62608,1.33496,1.26245,0.595071,0.531443,0.509215,1.17262,1.26539,1.05692,0.928366,0.563856,1.24872,1.37854,1.12409,1.12297,0.830796,1.18646,0.854628,0.689894,0.681267,0.744607,1.38039,0.685481,0.876299,1.63327,0.580657,1.1471,0.805461,1.14346,0.559153,1.45481,1.08896,0.965352,1.04338,1.68841,1.21376,0.928483,1.25534,1.55328,0.598722,1.36093,0.792832,1.52297,0.955954,1.65529,0.273451,0.762499,0.832891,1.60513,2.44352,2.04137,1.55966,0.978551,1.26,1.11604,0.831808,1.06002,2.40374,0.765221,0.589976,0.38417,0.260379,1.39822,1.28513,0.954936,1.48249,0.993889,0.622823,0.749933,0.762177,1.61484,1.32889,1.21423,0.741984,1.11251,0.94678,0.562367,0.904334,0.833542
|tfbs_overrepresentation_jaspar=MA0003.1;2.4568,MA0004.1;0.801718,MA0006.1;0.60285,MA0007.1;1.84502,MA0009.1;1.27673,MA0014.1;1.33691,MA0017.1;0.635031,MA0019.1;1.08369,MA0024.1;1.23079,MA0025.1;1.51835,MA0027.1;2.9431,MA0028.1;1.49373,MA0029.1;1.20789,MA0030.1;1.21482,MA0031.1;1.17722,MA0038.1;0.963265,MA0040.1;1.28983,MA0041.1;0.714279,MA0042.1;0.69885,MA0043.1;1.3775,MA0046.1;1.31428,MA0048.1;0.353763,MA0050.1;0.845669,MA0051.1;0.973068,MA0052.1;1.29825,MA0055.1;1.6728,MA0056.1;0,MA0057.1;0.337566,MA0058.1;0.690848,MA0059.1;0.705317,MA0060.1;0.502699,MA0061.1;0.5406,MA0063.1;0,MA0066.1;0.951196,MA0067.1;1.63197,MA0068.1;0.343188,MA0069.1;1.29861,MA0070.1;1.28847,MA0071.1;0.844726,MA0072.1;1.2796,MA0073.1;0.25258,MA0074.1;0.911576,MA0076.1;1.58243,MA0077.1;1.2569,MA0078.1;1.0091,MA0081.1;0.732313,MA0083.1;1.37668,MA0084.1;1.96428,MA0087.1;1.33189,MA0088.1;0.27999,MA0089.1;0,MA0090.1;0.762482,MA0091.1;0.816659,MA0092.1;0.762845,MA0093.1;1.51475,MA0095.1;0,MA0098.1;0,MA0100.1;0.89873,MA0101.1;0.71579,MA0103.1;0.647985,MA0105.1;1.04599,MA0106.1;1.01755,MA0107.1;0.640607,MA0108.2;1.10817,MA0109.1;0,MA0111.1;0.778753,MA0113.1;0.986839,MA0114.1;0.537669,MA0115.1;1.38041,MA0116.1;0.602598,MA0117.1;1.34691,MA0119.1;0.716476,MA0122.1;1.36752,MA0124.1;1.57762,MA0125.1;1.5017,MA0130.1;0,MA0131.1;1.07881,MA0132.1;0,MA0133.1;0,MA0135.1;1.4152,MA0136.1;0.933582,MA0139.1;1.16863,MA0140.1;0.898603,MA0141.1;0.671467,MA0142.1;1.16183,MA0143.1;1.00467,MA0144.1;0.541532,MA0145.1;0.794492,MA0146.1;4.37098,MA0147.1;0.556853,MA0148.1;0.820161,MA0149.1;0.722227,MA0062.2;1.06145,MA0035.2;0.903829,MA0039.2;2.07301,MA0138.2;1.07027,MA0002.2;0.466067,MA0137.2;0.668025,MA0104.2;0.48458,MA0047.2;0.962424,MA0112.2;0.29236,MA0065.2;0.292912,MA0150.1;0.784464,MA0151.1;0,MA0152.1;0.962542,MA0153.1;1.43238,MA0154.1;0.35067,MA0155.1;1.52001,MA0156.1;0.656895,MA0157.1;1.12772,MA0158.1;0,MA0159.1;0.569393,MA0160.1;0.823568,MA0161.1;0,MA0162.1;0.499274,MA0163.1;1.48428,MA0164.1;0.933981,MA0080.2;0.64167,MA0018.2;0.944669,MA0099.2;1.06348,MA0079.2;0.651053,MA0102.2;2.01714,MA0258.1;0.520639,MA0259.1;0.543506,MA0442.1;0
}}

Latest revision as of 19:46, 17 September 2013


Phase1 CAGE Peaks

 Short description
Mm9::chr1:107560446..107560497,+p1@2310035C23Rik
Mm9::chr3:152009429..152009495,+p1@Usp33
Mm9::chr9:64880220..64880273,+p1@Dpp8


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0004274dipeptidyl-peptidase IV activity0.011527492729213
GO:0008239dipeptidyl-peptidase activity0.011527492729213
GO:0016806dipeptidyl-peptidase and tripeptidyl-peptidase activity0.011527492729213
GO:0008233peptidase activity0.011527492729213
GO:0004177aminopeptidase activity0.0283509095421994
GO:0004221ubiquitin thiolesterase activity0.0325375515202056
GO:0004843ubiquitin-specific protease activity0.0325375515202056
GO:0019783small conjugating protein-specific protease activity0.0325375515202056
GO:0016790thiolester hydrolase activity0.0359570282017172
GO:0008238exopeptidase activity0.0359570282017172
GO:0016787hydrolase activity0.0394152488012717
GO:0008234cysteine-type peptidase activity0.0429744633852751
GO:0004252serine-type endopeptidase activity0.0429744633852751
GO:0044267cellular protein metabolic process0.0429744633852751
GO:0044260cellular macromolecule metabolic process0.0429744633852751
GO:0008236serine-type peptidase activity0.0429744633852751
GO:0017171serine hydrolase activity0.0429744633852751
GO:0019538protein metabolic process0.0429744633852751



Relative expression of the co-expression cluster over median <br>Analyst:




Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
CNS neuron (sensu Vertebrata)2.51e-0723
neuroblast (sensu Vertebrata)2.51e-0723

Uber Anatomy
Ontology termp-valuen
regional part of nervous system1.04e-1154
gray matter1.28e-1134
neural tube1.21e-1052
neural rod1.21e-1052
future spinal cord1.21e-1052
neural keel1.21e-1052
brain grey matter1.96e-0929
regional part of telencephalon1.96e-0929
telencephalon1.96e-0929
central nervous system4.35e-0973
neurectoderm8.36e-0964
neural plate8.36e-0964
presumptive neural plate8.36e-0964
nervous system9.69e-0975
brain1.28e-0847
future brain1.28e-0847
ecto-epithelium1.44e-0873
ectoderm-derived structure2.32e-0895
ectoderm2.32e-0895
presumptive ectoderm2.32e-0895
regional part of brain3.47e-0846
occipital lobe5.94e-0810
visual cortex5.94e-0810
neocortex5.94e-0810
anterior neural tube8.36e-0840
organ system subdivision1.14e-07194
regional part of forebrain2.25e-0739
forebrain2.25e-0739
future forebrain2.25e-0739
pre-chordal neural plate3.68e-0749


TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs




JASPAR motifs


Motifs-log10(p-value)
MA0003.12.4568
MA0004.10.801718
MA0006.10.60285
MA0007.11.84502
MA0009.11.27673
MA0014.11.33691
MA0017.10.635031
MA0019.11.08369
MA0024.11.23079
MA0025.11.51835
MA0027.12.9431
MA0028.11.49373
MA0029.11.20789
MA0030.11.21482
MA0031.11.17722
MA0038.10.963265
MA0040.11.28983
MA0041.10.714279
MA0042.10.69885
MA0043.11.3775
MA0046.11.31428
MA0048.10.353763
MA0050.10.845669
MA0051.10.973068
MA0052.11.29825
MA0055.11.6728
MA0056.10
MA0057.10.337566
MA0058.10.690848
MA0059.10.705317
MA0060.10.502699
MA0061.10.5406
MA0063.10
MA0066.10.951196
MA0067.11.63197
MA0068.10.343188
MA0069.11.29861
MA0070.11.28847
MA0071.10.844726
MA0072.11.2796
MA0073.10.25258
MA0074.10.911576
MA0076.11.58243
MA0077.11.2569
MA0078.11.0091
MA0081.10.732313
MA0083.11.37668
MA0084.11.96428
MA0087.11.33189
MA0088.10.27999
MA0089.10
MA0090.10.762482
MA0091.10.816659
MA0092.10.762845
MA0093.11.51475
MA0095.10
MA0098.10
MA0100.10.89873
MA0101.10.71579
MA0103.10.647985
MA0105.11.04599
MA0106.11.01755
MA0107.10.640607
MA0108.21.10817
MA0109.10
MA0111.10.778753
MA0113.10.986839
MA0114.10.537669
MA0115.11.38041
MA0116.10.602598
MA0117.11.34691
MA0119.10.716476
MA0122.11.36752
MA0124.11.57762
MA0125.11.5017
MA0130.10
MA0131.11.07881
MA0132.10
MA0133.10
MA0135.11.4152
MA0136.10.933582
MA0139.11.16863
MA0140.10.898603
MA0141.10.671467
MA0142.11.16183
MA0143.11.00467
MA0144.10.541532
MA0145.10.794492
MA0146.14.37098
MA0147.10.556853
MA0148.10.820161
MA0149.10.722227
MA0062.21.06145
MA0035.20.903829
MA0039.22.07301
MA0138.21.07027
MA0002.20.466067
MA0137.20.668025
MA0104.20.48458
MA0047.20.962424
MA0112.20.29236
MA0065.20.292912
MA0150.10.784464
MA0151.10
MA0152.10.962542
MA0153.11.43238
MA0154.10.35067
MA0155.11.52001
MA0156.10.656895
MA0157.11.12772
MA0158.10
MA0159.10.569393
MA0160.10.823568
MA0161.10
MA0162.10.499274
MA0163.11.48428
MA0164.10.933981
MA0080.20.64167
MA0018.20.944669
MA0099.21.06348
MA0079.20.651053
MA0102.22.01714
MA0258.10.520639
MA0259.10.543506
MA0442.10
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