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{{Coexpression_clusters
{
|coexpression_dpi_cluster_scores_median=0.249754250127642,

Latest revision as of 12:24, 17 September 2013


Full id: C3349_Smooth_Fibroblast_parotid_Preadipocyte_cholangiocellular_Neutrophils_salivary



Phase1 CAGE Peaks

Hg19::chr13:100153665..100153688,+p4@TM9SF2
Hg19::chr13:100153689..100153710,+p3@TM9SF2
Hg19::chr13:100153718..100153734,+p2@TM9SF2


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
multi-cellular organism3.09e-19656
anatomical group5.60e-19625
adult organism6.72e-19114
anatomical system1.54e-18624
organ3.66e-18503
embryonic structure9.25e-12564
germ layer6.60e-11560
germ layer / neural crest6.60e-11560
embryonic tissue6.60e-11560
presumptive structure6.60e-11560
germ layer / neural crest derived structure6.60e-11560
epiblast (generic)6.60e-11560
developing anatomical structure8.61e-11581
neural tube4.00e-1056
neural rod4.00e-1056
future spinal cord4.00e-1056
neural keel4.00e-1056
embryo1.46e-09592
regional part of forebrain1.92e-0941
forebrain1.92e-0941
anterior neural tube1.92e-0941
future forebrain1.92e-0941
regional part of nervous system2.59e-0953
regional part of brain2.59e-0953
organ system subdivision2.49e-08223
brain9.00e-0868
future brain9.00e-0868
telencephalon2.35e-0734
cerebral hemisphere3.82e-0732
brain grey matter5.40e-0734
gray matter5.40e-0734
regional part of cerebral cortex5.93e-0722
central nervous system7.64e-0781
regional part of telencephalon8.59e-0732


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0471418
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.10.118426
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.12.67616
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.11.06172
MA0056.10
MA0057.10.333427
MA0058.10.716037
MA0059.10.714521
MA0060.10.492218
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.0834661
MA0074.10.935474
MA0076.12.91768
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.12.03569
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.12.63873
MA0103.10.628063
MA0105.10.31555
MA0106.10.986396
MA0107.12.34614
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.11.3784
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.10.273764
MA0146.10.107247
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.21.9924
MA0035.22.07011
MA0039.20.0526989
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.20.491226
MA0047.20.973066
MA0112.20.264678
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.10.256269
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.11.43223
MA0163.10.122425
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.20.311277
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BHLHE40#8553344.87181354697741.10603738662898e-050.000283956338795831
CCNT2#90536.336201576962630.003930750035764890.0189504502139708
E2F1#186934.907389214879320.008460985347239390.0324158785282588
E2F6#187635.017155731697390.00791769806886330.0321070265429631
EGR1#195834.988179094810140.008056488137383440.0319575967404835
ELF1#199734.258097958807540.01295179875054610.0460735348516054
ELK4#2005316.2356816584680.0002336043955745990.00255309852128668
FOSL2#2355316.93020060456170.0002060162053171620.00242544543649184
GABPB1#255337.067683836182170.002832212825417420.0153762787999049
GATA1#2623313.56030814380040.0004009615963782630.00387203219270915
GTF2F1#2962312.73966087675770.0004835525047438590.00433082411825263
HNF4A#3172323.13229036295378.07584663437677e-050.0012259205619879
IRF4#3662321.91451268674419.49854535978121e-050.00136303734381724
JUN#3725312.51282919233630.0005103313992726250.00443525846788996
JUND#372736.994663941871030.002921845042734990.0156377254493287
MAX#414936.452555509007120.003721913834265510.0186067186317962
MXI1#460139.96157162875930.001011470541259020.007191080453271
MYC#460935.22228187160940.007020843755740150.0293628824685947
NANOG#79923329.24477848101273.99627955670032e-050.000735578851995462
NFKB1#479035.488063424193840.006049381815655430.0268961850764256
NRF1#4899312.21027944771090.0005492172401020010.00470045884938236
PAX5#507936.669565531177830.003370290999677260.0172518659861439
REST#597839.650028716128020.001112636247114590.00766103751400321
RFX5#5993312.04791082719510.0005717246050312580.0048352373491667
SIN3A#2594235.408884726815140.006318961977991520.0275862588312275
SP1#666735.69838137814090.005403962701712170.0245790636967214
SRF#6722313.79717826216780.0003806615025800190.0037427891798112
STAT1#6772320.70658749719920.0001125992441046670.00154570878746678
STAT3#6774310.51946499715420.0008589184530415310.00641755503771673
TCF7L2#6934310.77017656313730.0008003181298398380.00612295254284249
USF1#739136.361499277207960.00388404057290560.0189775585213421
YY1#752834.911170749853860.008441455341808260.032843465873528
ZEB1#6935316.88843201754390.0002075486917327580.00242246064102341
ZNF143#7702313.50087655222790.0004062804962997170.0038824712922542



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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