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Coexpression cluster:C2403: Difference between revisions

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|ontology_enrichment_disease=
|ontology_enrichment_disease=
|ontology_enrichment_uberon=UBERON:0007023!4.60e-32!115;UBERON:0001049!9.65e-17!57;UBERON:0005068!9.65e-17!57;UBERON:0006241!9.65e-17!57;UBERON:0007135!9.65e-17!57;UBERON:0003080!1.42e-14!42;UBERON:0002780!5.59e-14!41;UBERON:0001890!5.59e-14!41;UBERON:0006240!5.59e-14!41;UBERON:0000955!6.05e-13!69;UBERON:0006238!6.05e-13!69;UBERON:0002616!1.17e-11!59;UBERON:0004111!1.46e-11!241;UBERON:0003075!2.35e-11!86;UBERON:0007284!2.35e-11!86;UBERON:0001017!4.94e-11!82;UBERON:0001893!5.79e-11!34;UBERON:0002346!6.06e-11!90;UBERON:0000475!7.79e-11!365;UBERON:0004121!9.04e-11!169;UBERON:0005743!1.25e-10!86;UBERON:0000062!1.36e-10!511;UBERON:0000924!1.37e-10!173;UBERON:0006601!1.37e-10!173;UBERON:0000153!1.88e-10!129;UBERON:0007811!1.88e-10!129;UBERON:0002791!2.00e-10!33;UBERON:0002020!2.18e-10!34;UBERON:0003528!2.18e-10!34;UBERON:0000073!2.27e-10!94;UBERON:0001016!2.27e-10!94;UBERON:0001869!2.46e-10!32;UBERON:0000033!2.54e-10!123;UBERON:0002619!3.02e-10!22;UBERON:0000480!9.16e-10!626;UBERON:0000467!1.15e-09!625;UBERON:0001950!1.85e-09!20;UBERON:0000468!9.55e-09!659;UBERON:0003056!9.57e-09!61;UBERON:0000025!7.26e-08!194;UBERON:0000956!2.78e-07!25;UBERON:0000203!2.78e-07!25;UBERON:0000477!4.58e-07!286
|ontology_enrichment_uberon=UBERON:0007023!4.60e-32!115;UBERON:0001049!9.65e-17!57;UBERON:0005068!9.65e-17!57;UBERON:0006241!9.65e-17!57;UBERON:0007135!9.65e-17!57;UBERON:0003080!1.42e-14!42;UBERON:0002780!5.59e-14!41;UBERON:0001890!5.59e-14!41;UBERON:0006240!5.59e-14!41;UBERON:0000955!6.05e-13!69;UBERON:0006238!6.05e-13!69;UBERON:0002616!1.17e-11!59;UBERON:0004111!1.46e-11!241;UBERON:0003075!2.35e-11!86;UBERON:0007284!2.35e-11!86;UBERON:0001017!4.94e-11!82;UBERON:0001893!5.79e-11!34;UBERON:0002346!6.06e-11!90;UBERON:0000475!7.79e-11!365;UBERON:0004121!9.04e-11!169;UBERON:0005743!1.25e-10!86;UBERON:0000062!1.36e-10!511;UBERON:0000924!1.37e-10!173;UBERON:0006601!1.37e-10!173;UBERON:0000153!1.88e-10!129;UBERON:0007811!1.88e-10!129;UBERON:0002791!2.00e-10!33;UBERON:0002020!2.18e-10!34;UBERON:0003528!2.18e-10!34;UBERON:0000073!2.27e-10!94;UBERON:0001016!2.27e-10!94;UBERON:0001869!2.46e-10!32;UBERON:0000033!2.54e-10!123;UBERON:0002619!3.02e-10!22;UBERON:0000480!9.16e-10!626;UBERON:0000467!1.15e-09!625;UBERON:0001950!1.85e-09!20;UBERON:0000468!9.55e-09!659;UBERON:0003056!9.57e-09!61;UBERON:0000025!7.26e-08!194;UBERON:0000956!2.78e-07!25;UBERON:0000203!2.78e-07!25;UBERON:0000477!4.58e-07!286
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}}
}}

Revision as of 11:35, 5 September 2012


Full id: C2403_skeletal_cervix_eye_cerebellum_dura_testicular_mature



Phase1 CAGE Peaks

Hg19::chr17:38256799..38256815,-p3@NR1D1
Hg19::chr17:38256822..38256851,-p1@NR1D1
Hg19::chr17:38256858..38256866,-p6@NR1D1
Hg19::chr17:38256877..38256900,-p2@NR1D1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
adult organism4.60e-32115
neural tube9.65e-1757
neural rod9.65e-1757
future spinal cord9.65e-1757
neural keel9.65e-1757
anterior neural tube1.42e-1442
regional part of forebrain5.59e-1441
forebrain5.59e-1441
future forebrain5.59e-1441
brain6.05e-1369
future brain6.05e-1369
regional part of brain1.17e-1159
anatomical conduit1.46e-11241
neural plate2.35e-1186
presumptive neural plate2.35e-1186
central nervous system4.94e-1182
telencephalon5.79e-1134
neurectoderm6.06e-1190
organism subdivision7.79e-11365
ectoderm-derived structure9.04e-11169
organ1.36e-10511
ectoderm1.37e-10173
presumptive ectoderm1.37e-10173
anterior region of body1.88e-10129
craniocervical region1.88e-10129
regional part of telencephalon2.00e-1033
gray matter2.18e-1034
brain grey matter2.18e-1034
regional part of nervous system2.27e-1094
nervous system2.27e-1094
cerebral hemisphere2.46e-1032
head2.54e-10123
regional part of cerebral cortex3.02e-1022
anatomical group9.16e-10626
anatomical system1.15e-09625
neocortex1.85e-0920
multi-cellular organism9.55e-09659
pre-chordal neural plate9.57e-0961
tube7.26e-08194
cerebral cortex2.78e-0725
pallium2.78e-0725
anatomical cluster4.58e-07286


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
ATF3#467422.46317452600873.92475754624726e-060.000127376554808116
BHLHE40#8553444.87181354697742.46312701995675e-071.28366528361908e-05
CCNT2#90546.336201576962630.0006203100587215640.00511928583349043
E2F1#186944.907389214879320.001724022357361790.0106459629267728
E2F4#1874412.66806031528443.88145892637771e-050.000726479729053695
E2F6#187645.017155731697390.00157802193473060.0099653545072759
EGR1#195844.988179094810140.001615011500076050.0101400857314202
ELF1#199744.258097958807540.003041525565781240.016081298464265
EP300#203346.77394172622320.0004748459821442640.00433917573971168
FOXA1#3169411.08141974938556.62943068949433e-050.00106979467209533
FOXA2#3170212.31523187633260.009361916285467240.0353411832190383
GTF2F1#2962412.73966087675773.79492332235515e-050.000717353840476833
HDAC2#3066310.06171517746970.00156372754474740.00992368846362482
HEY1#2346244.040111043105710.00375304636917980.0185906094550735
IRF1#365947.63716375356390.0002938853996185490.00307330502160425
MAFF#23764342.23651736745892.20786227449124e-050.000483816466818277
MAFK#7975213.5503665689150.00777202812098050.0319555468259943
MAX#414946.452555509007120.0005767613195645490.00485229381778652
MXI1#460149.96157162875930.0001015224754950450.00142301782555724
MYC#460945.22228187160940.001344309395272740.00887137172582392
NFKB1#479045.488063424193840.001102199566301980.00767622169278556
NR3C1#2908414.9730233311731.98868032687801e-050.00044275375113795
NRF1#4899412.21027944771094.49717228915276e-050.000793512716179803
SIN3A#2594245.408884726815140.001168172384885160.00795739340627582
SIX5#147912417.0867153554591.17257016123224e-050.000297382358108144
SPI1#668848.204323508522730.000220661881527680.00249412405247504
SREBF1#6720447.00584944048832.04523668136926e-071.10104367920373e-05
STAT3#6774410.51946499715428.16377768286615e-050.00123068241544581
TAF1#687243.343046285745290.008005664898701650.0321962199682507
TBP#690843.706770687096390.005296377814784350.0243989414934614
TCF7L2#6934410.77017656313737.42969445082454e-050.00115348574215797
USF1#739146.361499277207960.0006105011399140830.00507684756361867
USF2#7392412.99219738506963.50833029870167e-050.000681306262674049
ZNF143#7702413.50087655222793.00867915035614e-050.000620626983575044
ZNF263#1012748.221841637010680.0002187871180958320.00248692945437642



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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