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Coexpression cluster:C3748: Difference between revisions

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|id=C3748
|id=C3748
|ontology_enrichment_celltype=
|ontology_enrichment_celltype=
|ontology_enrichment_disease=DOID:305!1.95e-09!106;DOID:0050687!6.17e-08!143
|ontology_enrichment_disease=DOID:305!2.13e-13!106;DOID:0050687!4.84e-11!143
|ontology_enrichment_uberon=UBERON:0007023!4.92e-30!115;UBERON:0000062!1.55e-15!511;UBERON:0001049!1.28e-14!57;UBERON:0005068!1.28e-14!57;UBERON:0006241!1.28e-14!57;UBERON:0007135!1.28e-14!57;UBERON:0000025!1.55e-14!194;UBERON:0004111!3.12e-13!241;UBERON:0000477!9.90e-13!286;UBERON:0005743!1.61e-12!86;UBERON:0001017!3.93e-12!82;UBERON:0003080!5.85e-12!42;UBERON:0002780!8.31e-12!41;UBERON:0001890!8.31e-12!41;UBERON:0006240!8.31e-12!41;UBERON:0003075!2.51e-11!86;UBERON:0007284!2.51e-11!86;UBERON:0000955!3.14e-11!69;UBERON:0006238!3.14e-11!69;UBERON:0000073!4.79e-11!94;UBERON:0001016!4.79e-11!94;UBERON:0002616!5.17e-11!59;UBERON:0000468!6.02e-11!659;UBERON:0002346!9.56e-10!90;UBERON:0002020!1.09e-09!34;UBERON:0003528!1.09e-09!34;UBERON:0000467!1.55e-09!625;UBERON:0000480!2.31e-09!626;UBERON:0001893!2.57e-09!34;UBERON:0002791!3.94e-09!33;UBERON:0000064!2.07e-08!219;UBERON:0001869!2.13e-08!32;UBERON:0000922!2.64e-08!612;UBERON:0000481!2.72e-08!347;UBERON:0002619!5.16e-08!22;UBERON:0005177!5.86e-08!107;UBERON:0000466!6.48e-08!126;UBERON:0003056!7.52e-08!61;UBERON:0000483!1.15e-07!309;UBERON:0000077!1.95e-07!130;UBERON:0004921!2.03e-07!129;UBERON:0004185!2.03e-07!129;UBERON:0000119!2.64e-07!312;UBERON:0005172!3.43e-07!55;UBERON:0005173!3.43e-07!55;UBERON:0001950!4.42e-07!20;UBERON:0000475!6.77e-07!365;UBERON:0002050!7.67e-07!605;UBERON:0005423!7.67e-07!605
|ontology_enrichment_uberon=UBERON:0007023!2.68e-32!114;UBERON:0001049!6.58e-15!56;UBERON:0005068!6.58e-15!56;UBERON:0006241!6.58e-15!56;UBERON:0007135!6.58e-15!56;UBERON:0011216!9.93e-15!223;UBERON:0000073!2.10e-13!53;UBERON:0002616!2.10e-13!53;UBERON:0001017!7.81e-13!81;UBERON:0000062!1.61e-11!503;UBERON:0000955!1.93e-11!68;UBERON:0006238!1.93e-11!68;UBERON:0000025!2.18e-11!192;UBERON:0002780!4.82e-11!41;UBERON:0001890!4.82e-11!41;UBERON:0003080!4.82e-11!41;UBERON:0006240!4.82e-11!41;UBERON:0001016!5.63e-11!89;UBERON:0004111!6.74e-11!240;UBERON:0000477!7.29e-11!373;UBERON:0003075!5.15e-10!82;UBERON:0007284!5.15e-10!82;UBERON:0003528!1.74e-09!34;UBERON:0002020!1.74e-09!34;UBERON:0001893!4.07e-09!34;UBERON:0002346!8.05e-09!86;UBERON:0002791!2.10e-08!32;UBERON:0001869!3.34e-08!32;UBERON:0005177!1.63e-07!101;UBERON:0000468!3.06e-07!656;UBERON:0000481!3.38e-07!342;UBERON:0004921!3.48e-07!118;UBERON:0000064!4.99e-07!218;UBERON:0000466!5.66e-07!117;UBERON:0009497!5.86e-07!25;UBERON:0000015!5.86e-07!25;UBERON:0002423!5.86e-07!25;UBERON:0006235!5.86e-07!25;UBERON:0004161!5.86e-07!25;UBERON:0002619!8.00e-07!22
|tf_chipseq_enrich=E2F1#1869;3:4.90738921487932:0.00846098534723939:0.0325256496127921
|tf_chipseq_enrich=E2F1#1869;3:4.90738921487932:0.00846098534723939:0.0325256496127921
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}}
}}

Revision as of 15:22, 19 October 2012


Full id: C3748_smallcell_thyroid_seminal_ductus_breast_somatostatinoma_small



Phase1 CAGE Peaks

Hg19::chr19:11529968..11529975,-p2@RGL3
Hg19::chr19:11529980..11529998,-p1@RGL3
Hg19::chr19:11530012..11530023,-p3@RGL3


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br>disease_data<br>


Uber Anatomy
Ontology termp-valuen
adult organism2.68e-32114
neural tube6.58e-1556
neural rod6.58e-1556
future spinal cord6.58e-1556
neural keel6.58e-1556
organ system subdivision9.93e-15223
regional part of nervous system2.10e-1353
regional part of brain2.10e-1353
central nervous system7.81e-1381
organ1.61e-11503
brain1.93e-1168
future brain1.93e-1168
tube2.18e-11192
regional part of forebrain4.82e-1141
forebrain4.82e-1141
anterior neural tube4.82e-1141
future forebrain4.82e-1141
nervous system5.63e-1189
anatomical conduit6.74e-11240
anatomical cluster7.29e-11373
neural plate5.15e-1082
presumptive neural plate5.15e-1082
brain grey matter1.74e-0934
gray matter1.74e-0934
telencephalon4.07e-0934
neurectoderm8.05e-0986
regional part of telencephalon2.10e-0832
cerebral hemisphere3.34e-0832
trunk region element1.63e-07101
multi-cellular organism3.06e-07656
multi-tissue structure3.38e-07342
subdivision of digestive tract3.48e-07118
organ part4.99e-07218
immaterial anatomical entity5.66e-07117
epithelium of foregut-midgut junction5.86e-0725
anatomical boundary5.86e-0725
hepatobiliary system5.86e-0725
foregut-midgut junction5.86e-0725
septum transversum5.86e-0725
regional part of cerebral cortex8.00e-0722
Disease
Ontology termp-valuen
carcinoma2.13e-13106
cell type cancer4.84e-11143


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
E2F1#186934.907389214879320.008460985347239390.0325256496127921



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.