MCL coexpression mm9:1678

Phase1 CAGE Peaks

	Short description
Mm9::chr15:64754697..64754724,-	p@chr15:64754697..64754724 -
Mm9::chr17:44215774..44215859,+	p1@Enpp5
Mm9::chr2:25562241..25562250,+	p4@Bmyc
Mm9::chrX:100129517..100129546,-	p1@Gm5126
Mm9::chrX:95345005..95345053,+	p1@Ar

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0004882	androgen receptor activity	0.00887476712104064
GO:0019102	male somatic sex determination	0.00887476712104064
GO:0018993	somatic sex determination	0.00887476712104064
GO:0030521	androgen receptor signaling pathway	0.00887476712104064
GO:0004551	nucleotide diphosphatase activity	0.0248425410174104
GO:0030238	male sex determination	0.0295695922158481
GO:0030518	steroid hormone receptor signaling pathway	0.0329435578149615
GO:0008584	male gonad development	0.0339808122707526
GO:0030522	intracellular receptor-mediated signaling pathway	0.0339808122707526
GO:0009166	nucleotide catabolic process	0.0339808122707526
GO:0046546	development of primary male sexual characteristics	0.0339808122707526
GO:0007530	sex determination	0.0339808122707526
GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	0.0341843773290768
GO:0046661	male sex differentiation	0.0341843773290768
GO:0003700	transcription factor activity	0.0406319634478141
GO:0005819	spindle	0.0420720492191018
GO:0005496	steroid binding	0.0446713847241321
GO:0003707	steroid hormone receptor activity	0.0446713847241321
GO:0004879	ligand-dependent nuclear receptor activity	0.0446713847241321
GO:0008406	gonad development	0.0446713847241321
GO:0048608	reproductive structure development	0.0446713847241321
GO:0045137	development of primary sexual characteristics	0.0466507962139251

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
ectodermal cell	2.85e-07	44
neurectodermal cell	2.85e-07	44
neural cell	5.85e-07	43
CNS neuron (sensu Vertebrata)	7.44e-07	23
neuroblast (sensu Vertebrata)	7.44e-07	23
non-terminally differentiated cell	7.67e-07	49

Uber Anatomy

Ontology term	p-value	n
central nervous system	1.63e-24	73
nervous system	1.13e-23	75
regional part of nervous system	3.18e-23	54
neural tube	8.24e-22	52
neural rod	8.24e-22	52
future spinal cord	8.24e-22	52
neural keel	8.24e-22	52
neurectoderm	1.27e-21	64
neural plate	1.27e-21	64
presumptive neural plate	1.27e-21	64
ectoderm-derived structure	7.29e-21	95
ectoderm	7.29e-21	95
presumptive ectoderm	7.29e-21	95
brain	5.82e-19	47
future brain	5.82e-19	47
ecto-epithelium	2.72e-18	73
regional part of brain	2.85e-18	46
anterior neural tube	4.62e-16	40
structure with developmental contribution from neural crest	6.20e-16	92
pre-chordal neural plate	1.38e-15	49
regional part of forebrain	2.05e-15	39
forebrain	2.05e-15	39
future forebrain	2.05e-15	39
gray matter	3.46e-14	34
brain grey matter	1.41e-11	29
regional part of telencephalon	1.41e-11	29
telencephalon	1.41e-11	29
anatomical conduit	1.48e-09	122
regional part of cerebral cortex	1.19e-08	17
occipital lobe	5.97e-08	10
visual cortex	5.97e-08	10
neocortex	5.97e-08	10
cerebral cortex	9.32e-08	21
cerebral hemisphere	9.32e-08	21
pallium	9.32e-08	21
tube	1.87e-07	114

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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