Coexpression cluster:C11: Difference between revisions
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|ontology_enrichment_uberon=UBERON:0000073!1.13e-44!94;UBERON:0001016!1.13e-44!94;UBERON:0001017!1.90e-42!82;UBERON:0005743!4.43e-42!86;UBERON:0007023!3.11e-38!115;UBERON:0000955!3.31e-35!69;UBERON:0006238!3.31e-35!69;UBERON:0001049!1.09e-34!57;UBERON:0005068!1.09e-34!57;UBERON:0006241!1.09e-34!57;UBERON:0007135!1.09e-34!57;UBERON:0002616!3.65e-33!59;UBERON:0002346!5.91e-32!90;UBERON:0000924!7.12e-31!173;UBERON:0006601!7.12e-31!173;UBERON:0003075!1.76e-30!86;UBERON:0007284!1.76e-30!86;UBERON:0004121!2.11e-29!169;UBERON:0003080!5.68e-26!42;UBERON:0002780!8.00e-26!41;UBERON:0001890!8.00e-26!41;UBERON:0006240!8.00e-26!41;UBERON:0002020!7.50e-22!34;UBERON:0003528!7.50e-22!34;UBERON:0001893!8.16e-22!34;UBERON:0000033!1.92e-21!123;UBERON:0000153!2.08e-21!129;UBERON:0007811!2.08e-21!129;UBERON:0003056!2.61e-21!61;UBERON:0002791!3.72e-21!33;UBERON:0001869!1.03e-20!32;UBERON:0000956!1.56e-16!25;UBERON:0000203!1.56e-16!25;UBERON:0002619!7.10e-16!22;UBERON:0001950!1.21e-14!20;UBERON:0000475!2.57e-11!365;UBERON:0003076!9.86e-10!15;UBERON:0003057!9.86e-10!15;UBERON:0000064!9.86e-09!219;UBERON:0004732!1.39e-08!13;UBERON:0004733!4.63e-08!12;UBERON:0002028!4.63e-08!12;UBERON:0007277!4.63e-08!12;UBERON:0000468!1.28e-07!659;UBERON:0000062!2.69e-07!511;UBERON:0000481!8.03e-07!347;UBERON:0002420!8.54e-07!9;UBERON:0007245!8.54e-07!9;UBERON:0010009!8.54e-07!9;UBERON:0010011!8.54e-07!9;UBERON:0000454!8.54e-07!9;UBERON:0002308!9.05e-07!9;UBERON:0000125!9.05e-07!9 | |ontology_enrichment_uberon=UBERON:0000073!1.13e-44!94;UBERON:0001016!1.13e-44!94;UBERON:0001017!1.90e-42!82;UBERON:0005743!4.43e-42!86;UBERON:0007023!3.11e-38!115;UBERON:0000955!3.31e-35!69;UBERON:0006238!3.31e-35!69;UBERON:0001049!1.09e-34!57;UBERON:0005068!1.09e-34!57;UBERON:0006241!1.09e-34!57;UBERON:0007135!1.09e-34!57;UBERON:0002616!3.65e-33!59;UBERON:0002346!5.91e-32!90;UBERON:0000924!7.12e-31!173;UBERON:0006601!7.12e-31!173;UBERON:0003075!1.76e-30!86;UBERON:0007284!1.76e-30!86;UBERON:0004121!2.11e-29!169;UBERON:0003080!5.68e-26!42;UBERON:0002780!8.00e-26!41;UBERON:0001890!8.00e-26!41;UBERON:0006240!8.00e-26!41;UBERON:0002020!7.50e-22!34;UBERON:0003528!7.50e-22!34;UBERON:0001893!8.16e-22!34;UBERON:0000033!1.92e-21!123;UBERON:0000153!2.08e-21!129;UBERON:0007811!2.08e-21!129;UBERON:0003056!2.61e-21!61;UBERON:0002791!3.72e-21!33;UBERON:0001869!1.03e-20!32;UBERON:0000956!1.56e-16!25;UBERON:0000203!1.56e-16!25;UBERON:0002619!7.10e-16!22;UBERON:0001950!1.21e-14!20;UBERON:0000475!2.57e-11!365;UBERON:0003076!9.86e-10!15;UBERON:0003057!9.86e-10!15;UBERON:0000064!9.86e-09!219;UBERON:0004732!1.39e-08!13;UBERON:0004733!4.63e-08!12;UBERON:0002028!4.63e-08!12;UBERON:0007277!4.63e-08!12;UBERON:0000468!1.28e-07!659;UBERON:0000062!2.69e-07!511;UBERON:0000481!8.03e-07!347;UBERON:0002420!8.54e-07!9;UBERON:0007245!8.54e-07!9;UBERON:0010009!8.54e-07!9;UBERON:0010011!8.54e-07!9;UBERON:0000454!8.54e-07!9;UBERON:0002308!9.05e-07!9;UBERON:0000125!9.05e-07!9 | ||
|pathway_enrichment=3.32290867772494e-05;0.00525850298249971;11;272;Neuroactive ligand-receptor interaction (KEGG):04080!1.37904446029163e-09;4.36467571682301e-07;12;126;Glutamatergic synapse (KEGG):04724!0.000175560589538046;0.0140469144364438;4;32;Hypothetical Network for Drug Addiction (Wikipathways):WP666!0.000158325689251421;0.0140469144364438;9;220;Signalling by NGF (Reactome):REACT_11061!1.98155139840225e-13;1.25432203518862e-10;18;197;Synaptic Transmission (Reactome):REACT_13685!0.000103236307343073;0.0130697165096331;7;121;Signaling by Rho GTPases (Reactome):REACT_11044!4.67969666896334e-06;0.000987415997151265;12;265;Axon guidance (Reactome):REACT_18266!0.000177528144536415;0.0140469144364438;7;132;{RAC1,133} (Static Module):NA | |pathway_enrichment=3.32290867772494e-05;0.00525850298249971;11;272;Neuroactive ligand-receptor interaction (KEGG):04080!1.37904446029163e-09;4.36467571682301e-07;12;126;Glutamatergic synapse (KEGG):04724!0.000175560589538046;0.0140469144364438;4;32;Hypothetical Network for Drug Addiction (Wikipathways):WP666!0.000158325689251421;0.0140469144364438;9;220;Signalling by NGF (Reactome):REACT_11061!1.98155139840225e-13;1.25432203518862e-10;18;197;Synaptic Transmission (Reactome):REACT_13685!0.000103236307343073;0.0130697165096331;7;121;Signaling by Rho GTPases (Reactome):REACT_11044!4.67969666896334e-06;0.000987415997151265;12;265;Axon guidance (Reactome):REACT_18266!0.000177528144536415;0.0140469144364438;7;132;{RAC1,133} (Static Module):NA | ||
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Revision as of 17:00, 8 August 2012
Full id: C11_cerebellum_medulla_pons_parietal_occipital_middle_medial
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
p.value | FDR | nGenes | nPathway | Name |
---|---|---|---|---|
3.32290867772494e-05 | 0.00525850298249971 | 11 | 272 | Neuroactive ligand-receptor interaction (KEGG):04080 |
1.37904446029163e-09 | 4.36467571682301e-07 | 12 | 126 | Glutamatergic synapse (KEGG):04724 |
0.000175560589538046 | 0.0140469144364438 | 4 | 32 | Hypothetical Network for Drug Addiction (Wikipathways):WP666 |
0.000158325689251421 | 0.0140469144364438 | 9 | 220 | Signalling by NGF (Reactome):REACT_11061 |
1.98155139840225e-13 | 1.25432203518862e-10 | 18 | 197 | Synaptic Transmission (Reactome):REACT_13685 |
0.000103236307343073 | 0.0130697165096331 | 7 | 121 | Signaling by Rho GTPases (Reactome):REACT_11044 |
4.67969666896334e-06 | 0.000987415997151265 | 12 | 265 | Axon guidance (Reactome):REACT_18266 |
0.000177528144536415 | 0.0140469144364438 | 7 | 132 | {RAC1,133} (Static Module):NA |
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0044459 | plasma membrane part | 8.95039221359773e-20 |
GO:0005886 | plasma membrane | 2.01315847348947e-16 |
GO:0051179 | localization | 1.97575936368077e-13 |
GO:0032501 | multicellular organismal process | 1.1610022726952e-12 |
GO:0031226 | intrinsic to plasma membrane | 3.10151637704027e-12 |
GO:0005887 | integral to plasma membrane | 2.06928397734449e-11 |
GO:0032502 | developmental process | 2.06928397734449e-11 |
GO:0007268 | synaptic transmission | 7.23814097715686e-11 |
GO:0005515 | protein binding | 7.23814097715686e-11 |
GO:0048856 | anatomical structure development | 7.23814097715686e-11 |
GO:0051234 | establishment of localization | 7.58149717241836e-11 |
GO:0015075 | ion transmembrane transporter activity | 1.0471142963076e-10 |
GO:0006810 | transport | 2.97738728180811e-10 |
GO:0019226 | transmission of nerve impulse | 4.21685231942799e-10 |
GO:0030054 | cell junction | 4.33291492323058e-10 |
GO:0044425 | membrane part | 8.57745798003385e-10 |
GO:0022836 | gated channel activity | 9.43439232656451e-10 |
GO:0016020 | membrane | 2.33742903617727e-09 |
GO:0006811 | ion transport | 3.13683353483321e-09 |
GO:0048731 | system development | 3.31000890280201e-09 |
GO:0007275 | multicellular organismal development | 4.02160804019907e-09 |
GO:0005216 | ion channel activity | 4.65989877275997e-09 |
GO:0008324 | cation transmembrane transporter activity | 4.65989877275997e-09 |
GO:0022838 | substrate specific channel activity | 5.45823608228912e-09 |
GO:0022803 | passive transmembrane transporter activity | 6.49436082600119e-09 |
GO:0015267 | channel activity | 6.49436082600119e-09 |
GO:0050877 | neurological system process | 1.33230794826933e-08 |
GO:0022891 | substrate-specific transmembrane transporter activity | 1.87167552470374e-08 |
GO:0044456 | synapse part | 2.34061104952865e-08 |
GO:0007267 | cell-cell signaling | 3.91715924990708e-08 |
GO:0048869 | cellular developmental process | 3.91715924990708e-08 |
GO:0030154 | cell differentiation | 3.91715924990708e-08 |
GO:0022843 | voltage-gated cation channel activity | 4.13333330355822e-08 |
GO:0007399 | nervous system development | 4.67616698467504e-08 |
GO:0005261 | cation channel activity | 6.6205638615038e-08 |
GO:0044464 | cell part | 8.14671771063909e-08 |
GO:0005244 | voltage-gated ion channel activity | 8.93093957634595e-08 |
GO:0022832 | voltage-gated channel activity | 8.93093957634595e-08 |
GO:0003008 | system process | 1.61871914169371e-07 |
GO:0022857 | transmembrane transporter activity | 2.00844628297963e-07 |
GO:0022892 | substrate-specific transporter activity | 4.89192818864187e-07 |
GO:0046873 | metal ion transmembrane transporter activity | 7.02814633385972e-07 |
GO:0045211 | postsynaptic membrane | 1.21319768669539e-06 |
GO:0007154 | cell communication | 1.65991336391032e-06 |
GO:0008076 | voltage-gated potassium channel complex | 2.65254064608992e-06 |
GO:0006812 | cation transport | 2.84801212936624e-06 |
GO:0005249 | voltage-gated potassium channel activity | 2.90686879595303e-06 |
GO:0005509 | calcium ion binding | 6.47200592031519e-06 |
GO:0030001 | metal ion transport | 1.03702029706372e-05 |
GO:0031224 | intrinsic to membrane | 1.73837065886193e-05 |
GO:0005267 | potassium channel activity | 2.82039392332996e-05 |
GO:0016021 | integral to membrane | 3.20818598382296e-05 |
GO:0031420 | alkali metal ion binding | 3.94245688872976e-05 |
GO:0009966 | regulation of signal transduction | 5.66648750624285e-05 |
GO:0001764 | neuron migration | 6.95795694097584e-05 |
GO:0030955 | potassium ion binding | 8.04349697139215e-05 |
GO:0019899 | enzyme binding | 9.53618787135913e-05 |
GO:0006813 | potassium ion transport | 0.000127848112633907 |
GO:0016192 | vesicle-mediated transport | 0.00017575140289126 |
GO:0007215 | glutamate signaling pathway | 0.00017575140289126 |
GO:0031267 | small GTPase binding | 0.000348161582413892 |
GO:0032940 | secretion by cell | 0.000432868760522367 |
GO:0050789 | regulation of biological process | 0.000512955498047487 |
GO:0000267 | cell fraction | 0.000586895320063018 |
GO:0007420 | brain development | 0.000586895320063018 |
GO:0007163 | establishment and/or maintenance of cell polarity | 0.000609370730832225 |
GO:0005624 | membrane fraction | 0.000620335112924781 |
GO:0015672 | monovalent inorganic cation transport | 0.000649500682258051 |
GO:0051020 | GTPase binding | 0.000652998863538523 |
GO:0046903 | secretion | 0.000658600241318867 |
GO:0030695 | GTPase regulator activity | 0.000773342842885876 |
GO:0051056 | regulation of small GTPase mediated signal transduction | 0.000940978215321049 |
GO:0006887 | exocytosis | 0.0013142015801768 |
GO:0065007 | biological regulation | 0.00140571737613608 |
GO:0016043 | cellular component organization and biogenesis | 0.00168241120197748 |
GO:0048468 | cell development | 0.00169884250311367 |
GO:0017016 | Ras GTPase binding | 0.00211049501023607 |
GO:0007417 | central nervous system development | 0.00213382261188462 |
GO:0007165 | signal transduction | 0.00215940648796517 |
GO:0001505 | regulation of neurotransmitter levels | 0.00215940648796517 |
GO:0045045 | secretory pathway | 0.00237331625134834 |
GO:0043005 | neuron projection | 0.00251791266927578 |
GO:0005230 | extracellular ligand-gated ion channel activity | 0.00287337637440084 |
GO:0005200 | structural constituent of cytoskeleton | 0.0030830464848088 |
GO:0051649 | establishment of cellular localization | 0.00318043401999249 |
GO:0004683 | calmodulin-dependent protein kinase activity | 0.00436743548108382 |
GO:0008066 | glutamate receptor activity | 0.0047527066497128 |
GO:0051641 | cellular localization | 0.0047527066497128 |
GO:0045055 | regulated secretory pathway | 0.00494759314947533 |
GO:0050794 | regulation of cellular process | 0.0052383974015421 |
GO:0030315 | T-tubule | 0.00531714314571773 |
GO:0007242 | intracellular signaling cascade | 0.00543401682066007 |
GO:0048513 | organ development | 0.00562499420679868 |
GO:0007264 | small GTPase mediated signal transduction | 0.00747218135114263 |
GO:0005242 | inward rectifier potassium channel activity | 0.00747218135114263 |
GO:0045664 | regulation of neuron differentiation | 0.00747218135114263 |
GO:0022834 | ligand-gated channel activity | 0.00807535838964554 |
GO:0015276 | ligand-gated ion channel activity | 0.00807535838964554 |
GO:0017137 | Rab GTPase binding | 0.00811357366566494 |
GO:0005088 | Ras guanyl-nucleotide exchange factor activity | 0.00816982219505662 |
GO:0005085 | guanyl-nucleotide exchange factor activity | 0.0101971359289449 |
GO:0048699 | generation of neurons | 0.0112145609579874 |
GO:0043167 | ion binding | 0.0115440309509001 |
GO:0005262 | calcium channel activity | 0.011657845141475 |
GO:0016079 | synaptic vesicle exocytosis | 0.0127421236737313 |
GO:0005231 | excitatory extracellular ligand-gated ion channel activity | 0.0132906186313827 |
GO:0007389 | pattern specification process | 0.0136178148015955 |
GO:0043169 | cation binding | 0.0157157594752251 |
GO:0015172 | acidic amino acid transmembrane transporter activity | 0.0157157594752251 |
GO:0022008 | neurogenesis | 0.0163357504716464 |
GO:0016247 | channel regulator activity | 0.016636560530117 |
GO:0006836 | neurotransmitter transport | 0.016636560530117 |
GO:0006357 | regulation of transcription from RNA polymerase II promoter | 0.0170156922417678 |
GO:0005891 | voltage-gated calcium channel complex | 0.0174081448513883 |
GO:0004970 | ionotropic glutamate receptor activity | 0.0174081448513883 |
GO:0021510 | spinal cord development | 0.0180707877847642 |
GO:0008037 | cell recognition | 0.0183423772970756 |
GO:0030425 | dendrite | 0.0183423772970756 |
GO:0009653 | anatomical structure morphogenesis | 0.0185605238006681 |
GO:0046872 | metal ion binding | 0.0191408345794866 |
GO:0005234 | extracellular-glutamate-gated ion channel activity | 0.0191408345794866 |
GO:0015296 | anion:cation symporter activity | 0.0191408345794866 |
GO:0007269 | neurotransmitter secretion | 0.0201190601864362 |
GO:0005516 | calmodulin binding | 0.0201190601864362 |
GO:0045665 | negative regulation of neuron differentiation | 0.0201190601864362 |
GO:0030742 | GTP-dependent protein binding | 0.0201190601864362 |
GO:0004185 | serine carboxypeptidase activity | 0.0201190601864362 |
GO:0008509 | anion transmembrane transporter activity | 0.021058995867896 |
GO:0030182 | neuron differentiation | 0.0214016881634762 |
GO:0042165 | neurotransmitter binding | 0.0219556619111336 |
GO:0007271 | synaptic transmission, cholinergic | 0.0231453047108904 |
GO:0042734 | presynaptic membrane | 0.0231453047108904 |
GO:0009986 | cell surface | 0.0234570797802473 |
GO:0006366 | transcription from RNA polymerase II promoter | 0.0244624587662845 |
GO:0015800 | acidic amino acid transport | 0.0264502183245596 |
GO:0015813 | L-glutamate transport | 0.0264502183245596 |
GO:0005083 | small GTPase regulator activity | 0.0296831813859555 |
GO:0048663 | neuron fate commitment | 0.0300764745902099 |
GO:0004985 | opioid receptor activity | 0.0300764745902099 |
GO:0016477 | cell migration | 0.0329357912950858 |
GO:0017153 | sodium:dicarboxylate symporter activity | 0.034076088846653 |
GO:0033036 | macromolecule localization | 0.036683504517018 |
GO:0042383 | sarcolemma | 0.0377270762249461 |
GO:0050804 | regulation of synaptic transmission | 0.0377270762249461 |
GO:0050714 | positive regulation of protein secretion | 0.0377270762249461 |
GO:0005794 | Golgi apparatus | 0.0411792321758828 |
GO:0045184 | establishment of protein localization | 0.0411792321758828 |
GO:0005310 | dicarboxylic acid transmembrane transporter activity | 0.0411792321758828 |
GO:0006835 | dicarboxylic acid transport | 0.0411792321758828 |
GO:0007612 | learning | 0.0411792321758828 |
GO:0051969 | regulation of transmission of nerve impulse | 0.0426499085200911 |
GO:0048489 | synaptic vesicle transport | 0.0426499085200911 |
GO:0015459 | potassium channel regulator activity | 0.0426499085200911 |
GO:0015294 | solute:cation symporter activity | 0.0426499085200911 |
GO:0006816 | calcium ion transport | 0.0426499085200911 |
GO:0021902 | commitment of a neuronal cell to a specific type of neuron in the forebrain | 0.0426499085200911 |
GO:0045836 | positive regulation of meiosis | 0.0426499085200911 |
GO:0008322 | Pro-X carboxypeptidase activity | 0.0426499085200911 |
GO:0000789 | cytoplasmic chromatin | 0.0426499085200911 |
GO:0005600 | collagen type XIII | 0.0426499085200911 |
GO:0002355 | detection of tumor cell | 0.0426499085200911 |
GO:0021527 | spinal cord association neuron differentiation | 0.0426499085200911 |
GO:0043522 | leucine zipper domain binding | 0.0426499085200911 |
GO:0007196 | metabotropic glutamate receptor, adenylate cyclase inhibiting pathway | 0.0426499085200911 |
GO:0032223 | negative regulation of synaptic transmission, cholinergic | 0.0426499085200911 |
GO:0006992 | sterol depletion response, sterol regulatory element binding protein cleavage | 0.0426499085200911 |
GO:0030936 | transmembrane collagen | 0.0426499085200911 |
GO:0048172 | regulation of short-term neuronal synaptic plasticity | 0.0426499085200911 |
GO:0035103 | sterol regulatory element binding protein cleavage | 0.0426499085200911 |
GO:0004188 | serine-type Pro-X carboxypeptidase activity | 0.0426499085200911 |
GO:0008321 | Ral guanyl-nucleotide exchange factor activity | 0.0426499085200911 |
GO:0045199 | maintenance of epithelial cell polarity | 0.0426499085200911 |
GO:0021877 | forebrain neuron fate commitment | 0.0426499085200911 |
GO:0032222 | regulation of synaptic transmission, cholinergic | 0.0426499085200911 |
GO:0000229 | cytoplasmic chromosome | 0.0426499085200911 |
GO:0021516 | dorsal spinal cord development | 0.0426499085200911 |
GO:0031557 | induction of programmed cell death in response to chemical stimulus | 0.0426499085200911 |
GO:0030507 | spectrin binding | 0.0426499085200911 |
GO:0019905 | syntaxin binding | 0.0426499085200911 |
GO:0008134 | transcription factor binding | 0.0435744198090368 |
GO:0019932 | second-messenger-mediated signaling | 0.049290957571924 |
GO:0000074 | regulation of progression through cell cycle | 0.0495656003067084 |
GO:0003700 | transcription factor activity | 0.0499293279617277 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>
Ontology term | p-value | n |
---|---|---|
neural cell | 3.29e-08 | 25 |
Ontology term | p-value | n |
---|---|---|
germ cell and embryonal cancer | 6.39e-07 | 22 |
germ cell cancer | 6.39e-07 | 22 |
Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
{{{tfbs_overrepresentation_jaspar}}} |
ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
No analysis results for this cluster
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data
"{{{coexpression_dpi_cluster_scores_median}}}" is not a number.