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Coexpression cluster:C2526: Difference between revisions

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|tf_chipseq_enrich=CTCF#10664;4:5.36025637307503:0.00121114538164362:0.00817546616555573
|tf_chipseq_enrich=CTCF#10664;4:5.36025637307503:0.00121114538164362:0.00817546616555573
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}}
}}

Revision as of 15:33, 26 November 2012


Full id: C2526_acute_CD14_CD14CD16_Whole_CD4_biphenotypic_Dendritic



Phase1 CAGE Peaks

Hg19::chr1:151129103..151129130,+p2@TNFAIP8L2
Hg19::chr1:151129135..151129165,+p1@TNFAIP8L2
Hg19::chr8:22437965..22438000,+p3@PDLIM2
Hg19::chr8:22438009..22438035,+p4@PDLIM2


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
hematopoietic stem cell1.94e-90168
angioblastic mesenchymal cell1.94e-90168
hematopoietic oligopotent progenitor cell4.80e-86161
hematopoietic multipotent progenitor cell4.80e-86161
hematopoietic cell3.85e-84177
leukocyte6.64e-73136
hematopoietic lineage restricted progenitor cell2.54e-63120
nongranular leukocyte5.79e-62115
myeloid cell2.31e-58108
common myeloid progenitor2.31e-58108
myeloid leukocyte1.70e-4272
granulocyte monocyte progenitor cell9.52e-3967
myeloid lineage restricted progenitor cell3.07e-3866
macrophage dendritic cell progenitor1.78e-3661
monopoietic cell9.31e-3659
monocyte9.31e-3659
monoblast9.31e-3659
promonocyte9.31e-3659
defensive cell1.17e-3048
phagocyte1.17e-3048
classical monocyte4.90e-2642
CD14-positive, CD16-negative classical monocyte4.90e-2642
nucleate cell2.73e-2355
lymphocyte9.89e-2353
common lymphoid progenitor9.89e-2353
lymphoid lineage restricted progenitor cell2.37e-2252
mesenchymal cell3.19e-14354
T cell2.32e-1325
pro-T cell2.32e-1325
connective tissue cell5.68e-13361
mature alpha-beta T cell3.21e-1118
alpha-beta T cell3.21e-1118
immature T cell3.21e-1118
mature T cell3.21e-1118
immature alpha-beta T cell3.21e-1118
lymphocyte of B lineage3.38e-0924
pro-B cell3.38e-0924
motile cell7.73e-09386
stuff accumulating cell1.88e-0887
intermediate monocyte3.12e-089
CD14-positive, CD16-positive monocyte3.12e-089
CD8-positive, alpha-beta T cell4.78e-0811
B cell8.25e-0714
Uber Anatomy
Ontology termp-valuen
hematopoietic system8.90e-4498
blood island8.90e-4498
hemolymphoid system1.30e-38108
bone marrow7.12e-3276
immune system1.44e-3093
bone element4.96e-3082
skeletal element5.27e-2690
skeletal system3.52e-21100
adult organism4.26e-17114
connective tissue1.04e-11371
lateral plate mesoderm1.99e-10203
blood7.44e-0915
haemolymphatic fluid7.44e-0915
organism substance7.44e-0915
Disease
Ontology termp-valuen
leukemia2.14e-1839
hematologic cancer1.17e-1751
immune system cancer1.17e-1751
myeloid leukemia2.51e-1531


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CTCF#1066445.360256373075030.001211145381643620.00817546616555573



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.