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Coexpression cluster:C2192

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Full id: C2192_small_signet_gastric_adenocarcinoma_colon_bile_duodenum



Phase1 CAGE Peaks

Hg19::chr12:12223867..12223883,+p1@BCL2L14
Hg19::chr2:241544820..241544829,+p6@GPR35
Hg19::chr2:241544834..241544861,+p2@GPR35
Hg19::chr2:241544866..241544882,+p4@GPR35


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br>disease_data<br>


Uber Anatomy
Ontology termp-valuen
adult organism4.35e-34115
neural tube1.33e-2357
neural rod1.33e-2357
future spinal cord1.33e-2357
neural keel1.33e-2357
central nervous system6.00e-1982
regional part of brain2.02e-1859
brain4.94e-1869
future brain4.94e-1869
anterior neural tube2.02e-1642
regional part of forebrain1.13e-1541
forebrain1.13e-1541
future forebrain1.13e-1541
gray matter1.73e-1534
brain grey matter1.73e-1534
telencephalon6.09e-1534
regional part of nervous system8.76e-1594
nervous system8.76e-1594
regional part of telencephalon2.16e-1433
subdivision of digestive tract1.03e-13129
endodermal part of digestive tract1.03e-13129
cerebral hemisphere1.25e-1332
neural plate9.47e-1386
presumptive neural plate9.47e-1386
anterior region of body3.85e-12129
craniocervical region3.85e-12129
digestive system4.46e-12155
digestive tract4.46e-12155
primitive gut4.46e-12155
regional part of cerebral cortex5.85e-1222
neurectoderm1.43e-1190
gastrointestinal system5.49e-1135
neocortex1.78e-1020
head3.89e-10123
endoderm-derived structure4.25e-10169
endoderm4.25e-10169
presumptive endoderm4.25e-10169
cerebral cortex7.03e-1025
pallium7.03e-1025
mixed endoderm/mesoderm-derived structure1.54e-09130
pre-chordal neural plate7.07e-0961
brainstem8.17e-098
posterior neural tube1.78e-0815
chordal neural plate1.78e-0815
organ1.00e-07511
nucleus of brain1.68e-079
neural nucleus1.68e-079
anatomical conduit1.90e-07241
foregut3.06e-0798
tube3.53e-07194
intestine3.76e-0727
Disease
Ontology termp-valuen
carcinoma8.42e-10106


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.