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Coexpression cluster:C4601

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Full id: C4601_Dendritic_myeloma_lymphangiectasia_xeroderma_adult_hairy_B



Phase1 CAGE Peaks

Hg19::chr6:397136..397160,-p@chr6:397136..397160
-
Hg19::chr6:407647..407650,+p@chr6:407647..407650
+
Hg19::chr6:409027..409044,+p@chr6:409027..409044
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
leukocyte4.54e-51140
nongranular leukocyte4.21e-45119
hematopoietic lineage restricted progenitor cell5.56e-42124
hematopoietic cell1.14e-38182
hematopoietic stem cell1.15e-38172
angioblastic mesenchymal cell1.15e-38172
lymphocyte2.55e-3653
common lymphoid progenitor2.55e-3653
hematopoietic oligopotent progenitor cell1.69e-35165
hematopoietic multipotent progenitor cell1.69e-35165
lymphoid lineage restricted progenitor cell3.67e-3552
lymphocyte of B lineage4.61e-2524
pro-B cell4.61e-2524
dendritic cell2.32e-1410
B cell2.63e-1414
macrophage dendritic cell progenitor4.63e-1265
conventional dendritic cell7.20e-128
CD14-positive, CD16-negative classical monocyte7.82e-1242
granulocyte monocyte progenitor cell1.03e-1171
classical monocyte2.44e-1145
myeloid leukocyte5.28e-1176
monopoietic cell8.42e-1163
monocyte8.42e-1163
monoblast8.42e-1163
promonocyte8.42e-1163
T cell2.36e-1025
pro-T cell2.36e-1025
myeloid lineage restricted progenitor cell3.25e-1070
myeloid cell1.24e-08112
common myeloid progenitor1.24e-08112
mature alpha-beta T cell2.62e-0818
alpha-beta T cell2.62e-0818
immature T cell2.62e-0818
mature T cell2.62e-0818
immature alpha-beta T cell2.62e-0818
immature conventional dendritic cell3.27e-085
common dendritic progenitor3.27e-085
motile cell1.69e-07390
circulating cell2.29e-076
melanocyte3.33e-0710
melanoblast3.33e-0710
Langerhans cell3.78e-075
mesenchymal cell7.23e-07358
Uber Anatomy
Ontology termp-valuen
hematopoietic system4.31e-20102
blood island4.31e-20102
hemolymphoid system1.51e-18112
bone marrow4.00e-1080
immune system5.77e-10115
blood1.25e-0915
haemolymphatic fluid1.25e-0915
organism substance1.25e-0915
bone element1.09e-0886
Disease
Ontology termp-valuen
lymphoma1.46e-0910


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.