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Coexpression cluster:C155

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Full id: C155_pituitary_placenta_nonsmall_cervical_smallcell_choriocarcinoma_epitheloid



Phase1 CAGE Peaks

Hg19::chr10:124615386..124615429,-p@chr10:124615386..124615429
-
Hg19::chr11:30252514..30252529,+p4@FSHB
Hg19::chr11:30252549..30252565,+p1@FSHB
Hg19::chr11:46295968..46295985,-p1@ENST00000527239
Hg19::chr11:70178863..70178874,+p@chr11:70178863..70178874
+
Hg19::chr12:7341800..7341812,+p5@PEX5
Hg19::chr13:78813679..78813681,-p@chr13:78813679..78813681
-
Hg19::chr14:101193418..101193423,+p8@DLK1
Hg19::chr16:60564560..60564561,+p@chr16:60564560..60564561
+
Hg19::chr17:18012035..18012048,+p2@MYO15A
Hg19::chr17:185919..185925,-p@chr17:185919..185925
-
Hg19::chr17:26877299..26877303,+p@chr17:26877299..26877303
+
Hg19::chr17:61973929..61973936,-p3@CSH1
Hg19::chr17:61994613..61994649,-p@chr17:61994613..61994649
-
Hg19::chr17:61994760..61994767,+p@chr17:61994760..61994767
+
Hg19::chr17:61994797..61994839,-p@chr17:61994797..61994839
-
Hg19::chr17:61995172..61995199,-p@chr17:61995172..61995199
-
Hg19::chr17:61995207..61995219,-p@chr17:61995207..61995219
-
Hg19::chr17:61995220..61995244,-p@chr17:61995220..61995244
-
Hg19::chr17:61995371..61995384,+p@chr17:61995371..61995384
+
Hg19::chr17:61995410..61995414,-p@chr17:61995410..61995414
-
Hg19::chr17:61995432..61995458,-p@chr17:61995432..61995458
-
Hg19::chr17:61995480..61995499,-p@chr17:61995480..61995499
-
Hg19::chr17:61995704..61995739,+p@chr17:61995704..61995739
+
Hg19::chr17:61995740..61995772,-p1@AB591020
Hg19::chr17:61996192..61996199,-p1@GH1
p2@CSHL1
Hg19::chr17:76919498..76919500,+p@chr17:76919498..76919500
+
Hg19::chr18:13915530..13915540,-p1@MC2R
Hg19::chr19:4769143..4769147,+p1@MIR7-3HG
Hg19::chr19:4772190..4772197,+p@chr19:4772190..4772197
+
Hg19::chr19:49519347..49519354,-p3@CU678753
Hg19::chr19:49519357..49519372,-p1@CU678753
Hg19::chr19:49519519..49519562,-p2@CU678753
Hg19::chr19:49519930..49519937,-p@chr19:49519930..49519937
-
Hg19::chr19:49520344..49520367,-p1@LHB
Hg19::chr19:49547457..49547458,+p2@CGB5
Hg19::chr19:7979644..7979653,+p@chr19:7979644..7979653
+
Hg19::chr19:7979665..7979675,+p@chr19:7979665..7979675
+
Hg19::chr19:7979677..7979703,+p@chr19:7979677..7979703
+
Hg19::chr19:7979708..7979734,+p@chr19:7979708..7979734
+
Hg19::chr1:115572444..115572451,+p1@TSHB
Hg19::chr1:151696600..151696645,+p@chr1:151696600..151696645
+
Hg19::chr1:19435681..19435684,+p@chr1:19435681..19435684
+
Hg19::chr1:2036352..2036358,-p@chr1:2036352..2036358
-
Hg19::chr1:233598660..233598662,-p@chr1:233598660..233598662
-
Hg19::chr1:240043364..240043366,+p@chr1:240043364..240043366
+
Hg19::chr1:65990750..65990756,+p@chr1:65990750..65990756
+
Hg19::chr20:19714764..19714765,+p@chr20:19714764..19714765
+
Hg19::chr20:33567825..33567827,-p@chr20:33567825..33567827
-
Hg19::chr20:36511296..36511298,+p@chr20:36511296..36511298
+
Hg19::chr20:5903139..5903148,+p@chr20:5903139..5903148
+
Hg19::chr20:5903320..5903383,-p@chr20:5903320..5903383
-
Hg19::chr22:19373363..19373368,+p@chr22:19373363..19373368
+
Hg19::chr22:47126639..47126654,+p@chr22:47126639..47126654
+
Hg19::chr2:175434561..175434564,+p@chr2:175434561..175434564
+
Hg19::chr2:193063406..193063411,-p@chr2:193063406..193063411
-
Hg19::chr2:241080069..241080082,-p1@OTOS
Hg19::chr2:863855..863859,-p2@ENST00000415700
p2@uc002qwn.1
p2@uc002qwo.1
Hg19::chr2:863883..863897,-p1@ENST00000415700
p1@uc002qwn.1
p1@uc002qwo.1
Hg19::chr3:187654553..187654555,+p@chr3:187654553..187654555
+
Hg19::chr3:53894448..53894449,+p@chr3:53894448..53894449
+
Hg19::chr3:56445982..56445989,+p@chr3:56445982..56445989
+
Hg19::chr4:166300084..166300091,+p8@CPE
Hg19::chr4:68620100..68620112,-p1@GNRHR
Hg19::chr5:462101..462128,+p8@EXOC3
Hg19::chr5:79375654..79375674,+p@chr5:79375654..79375674
+
Hg19::chr5:79375715..79375734,+p@chr5:79375715..79375734
+
Hg19::chr5:79375755..79375801,+p@chr5:79375755..79375801
+
Hg19::chr6:22287647..22287662,-p@chr6:22287647..22287662
-
Hg19::chr6:22287710..22287718,-p@chr6:22287710..22287718
-
Hg19::chr6:22287720..22287725,-p@chr6:22287720..22287725
-
Hg19::chr6:22287728..22287735,-p@chr6:22287728..22287735
-
Hg19::chr6:22287747..22287758,-p@chr6:22287747..22287758
-
Hg19::chr6:22287768..22287781,-p@chr6:22287768..22287781
-
Hg19::chr6:22287787..22287798,-p@chr6:22287787..22287798
-
Hg19::chr6:22287815..22287820,-p@chr6:22287815..22287820
-
Hg19::chr6:22290440..22290455,+p@chr6:22290440..22290455
+
Hg19::chr6:22290447..22290450,-p@chr6:22290447..22290450
-
Hg19::chr6:22290473..22290492,-p@chr6:22290473..22290492
-
Hg19::chr6:22290492..22290497,+p@chr6:22290492..22290497
+
Hg19::chr6:22290499..22290506,+p@chr6:22290499..22290506
+
Hg19::chr6:22292805..22292814,-p@chr6:22292805..22292814
-
Hg19::chr6:22292828..22292837,-p@chr6:22292828..22292837
-
Hg19::chr6:22292841..22292854,-p@chr6:22292841..22292854
-
Hg19::chr6:22294671..22294709,-p2@PRL
Hg19::chr6:22294718..22294725,-p11@PRL
Hg19::chr6:22294730..22294743,-p6@PRL
Hg19::chr6:22294755..22294768,-p9@PRL
Hg19::chr6:22294783..22294799,-p5@PRL
Hg19::chr6:22294803..22294830,-p7@PRL
Hg19::chr6:31744574..31744603,-p4@VWA7
Hg19::chr6:74072975..74072976,-p@chr6:74072975..74072976
-
Hg19::chr6:87795324..87795331,-p@chr6:87795324..87795331
-
Hg19::chr6:87795365..87795378,-p@chr6:87795365..87795378
-
Hg19::chr6:87804815..87804830,-p1@CGA
Hg19::chr7:116689..116690,+p@chr7:116689..116690
+
Hg19::chr7:130010774..130010781,-p@chr7:130010774..130010781
-
Hg19::chr7:31003593..31003614,+p2@GHRHR
Hg19::chr7:31003621..31003641,+p3@GHRHR
Hg19::chr7:31006831..31006834,+p@chr7:31006831..31006834
+
Hg19::chr8:112641680..112641681,+p@chr8:112641680..112641681
+
Hg19::chr8:126582844..126582849,-p@chr8:126582844..126582849
-
Hg19::chr8:143411767..143411777,+p@chr8:143411767..143411777
+
Hg19::chr9:75733141..75733143,+p@chr9:75733141..75733143
+
Hg19::chr9:92757667..92757670,+p@chr9:92757667..92757670
+
Hg19::chrX:103145056..103145060,+p@chrX:103145056..103145060
+
Hg19::chrX:130215564..130215579,+p@chrX:130215564..130215579
+
Hg19::chrX:130423225..130423228,-p5@IGSF1
Hg19::chrX:45029527..45029529,-p@chrX:45029527..45029529
-
Hg19::chrX:48689717..48689744,-p@chrX:48689717..48689744
-
Hg19::chrX:54051809..54051811,+p@chrX:54051809..54051811
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

p.valueFDRnGenesnPathwayName
1.28980561285789e-148.16446952939045e-129272Neuroactive ligand-receptor interaction (KEGG):04080
3.39083674685837e-070.0001073199830380674101GnRH signaling pathway (KEGG):04912
0.0004690548717164540.0494852889660859254Autoimmune thyroid disease (KEGG):05320
5.64655121093405e-070.0001191422305507087932Signaling by GPCR (Reactome):REACT_14797
4.68717995579227e-060.0005933969824033024195Metabolism of amino acids and derivatives (Reactome):REACT_13
2.72912932716038e-060.000431884716023136733{ARRB2,743} (Static Module):NA



Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0005179hormone activity4.70217539406628e-06
GO:0005625soluble fraction4.70217539406628e-06
GO:0007165signal transduction0.000669354161378072
GO:0007154cell communication0.00102865316074998
GO:0008584male gonad development0.00116701178172978
GO:0000267cell fraction0.00116701178172978
GO:0046546development of primary male sexual characteristics0.00170211124438285
GO:0005102receptor binding0.00170211124438285
GO:0032501multicellular organismal process0.00195375485702507
GO:0046661male sex differentiation0.00199734198145008
GO:0008406gonad development0.00406384487868871
GO:0048608reproductive structure development0.00406384487868871
GO:0007275multicellular organismal development0.00406384487868871
GO:0032502developmental process0.00406384487868871
GO:0022414reproductive process0.00406384487868871
GO:0045137development of primary sexual characteristics0.00406384487868871
GO:0048609reproductive process in a multicellular organism0.00406384487868871
GO:0032504multicellular organism reproduction0.00406384487868871
GO:0007166cell surface receptor linked signal transduction0.00410264335334982
GO:0030070insulin processing0.00410264335334982
GO:0004978adrenocorticotropin receptor activity0.00410264335334982
GO:0016913follicle-stimulating hormone activity0.00410264335334982
GO:0004183carboxypeptidase E activity0.00410264335334982
GO:0048187inhibin beta-B binding0.00410264335334982
GO:0007186G-protein coupled receptor protein signaling pathway0.00477227000525781
GO:0007565female pregnancy0.00477227000525781
GO:0007548sex differentiation0.00477227000525781
GO:0003006reproductive developmental process0.00530528956091789
GO:0048186inhibin beta-A binding0.00656287675267367
GO:0005148prolactin receptor binding0.00656287675267367
GO:0007187G-protein signaling, coupled to cyclic nucleotide second messenger0.00820190560634466
GO:0048513organ development0.00820190560634466
GO:0048856anatomical structure development0.00820190560634466
GO:0019935cyclic-nucleotide-mediated signaling0.00820190560634466
GO:0004968gonadotropin-releasing hormone receptor activity0.00820190560634466
GO:0060011Sertoli cell proliferation0.00820190560634466
GO:0050954sensory perception of mechanical stimulus0.00893161013195159
GO:0007605sensory perception of sound0.00893161013195159
GO:0048184follistatin binding0.0100925731730377
GO:0007267cell-cell signaling0.0142560561162987
GO:0048185activin binding0.0143944457968459
GO:0016486peptide hormone processing0.0160091274579621
GO:0007516hemocyte development0.0160091274579621
GO:0042386hemocyte differentiation0.017479382187223
GO:0051592response to calcium ion0.017479382187223
GO:0004977melanocortin receptor activity0.019232857529668
GO:0048731system development0.02114152694078
GO:0004999vasoactive intestinal polypeptide receptor activity0.026601334373413
GO:0019932second-messenger-mediated signaling0.0276871209729411
GO:0001541ovarian follicle development0.0353229218256498
GO:0007530sex determination0.0389003673633559
GO:0007595lactation0.0389003673633559
GO:0051704multi-organism process0.0389003673633559
GO:0016500protein-hormone receptor activity0.0392153810759798
GO:0043627response to estrogen stimulus0.0392153810759798
GO:0007190adenylate cyclase activation0.0402575045364685
GO:0022601menstrual cycle phase0.0404270122573776
GO:0022602menstrual cycle process0.0404270122573776
GO:0046983protein dimerization activity0.0404270122573776
GO:0045762positive regulation of adenylate cyclase activity0.0404270122573776
GO:0031281positive regulation of cyclase activity0.0404270122573776
GO:0051349positive regulation of lyase activity0.0404270122573776
GO:0042562hormone binding0.0404270122573776
GO:0008585female gonad development0.0413174251168308
GO:0046545development of primary female sexual characteristics0.0430154782450233
GO:0046660female sex differentiation0.0430154782450233
GO:0042698menstrual cycle0.0481783978042076
GO:0007292female gamete generation0.0495967772577401
GO:0010038response to metal ion0.0495967772577401



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
adult organism2.26e-33115
central nervous system2.78e-2682
neural tube8.19e-2657
neural rod8.19e-2657
future spinal cord8.19e-2657
neural keel8.19e-2657
regional part of nervous system9.06e-2494
nervous system9.06e-2494
regional part of brain2.72e-2259
brain4.02e-2169
future brain4.02e-2169
regional part of forebrain1.19e-2041
forebrain1.19e-2041
future forebrain1.19e-2041
anterior neural tube2.86e-2042
neural plate3.45e-2086
presumptive neural plate3.45e-2086
neurectoderm4.11e-2090
gray matter1.30e-1634
brain grey matter1.30e-1634
telencephalon1.81e-1634
regional part of telencephalon6.35e-1633
cerebral hemisphere7.10e-1632
regional part of cerebral cortex1.25e-1422
pre-chordal neural plate4.28e-1461
neocortex2.29e-1320
cerebral cortex4.12e-1225
pallium4.12e-1225
ectoderm9.48e-12173
presumptive ectoderm9.48e-12173
ectoderm-derived structure1.48e-11169
anterior region of body2.42e-10129
craniocervical region2.42e-10129
tube5.27e-10194
head8.81e-10123
organ1.47e-08511
anatomical conduit1.04e-07241
embryo1.20e-07612
multi-cellular organism1.73e-07659
posterior neural tube8.99e-0715
chordal neural plate8.99e-0715


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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