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Coexpression cluster:C395

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Full id: C395_Synoviocyte_Cardiac_Fibroblast_mesothelioma_Endothelial_Chondrocyte_tenocyte



Phase1 CAGE Peaks

Hg19::chr2:56094041..56094058,-p@chr2:56094041..56094058
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Hg19::chr2:56094202..56094227,-p@chr2:56094202..56094227
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Hg19::chr2:56098185..56098199,-p@chr2:56098185..56098199
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Hg19::chr2:56102125..56102145,-p@chr2:56102125..56102145
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Hg19::chr2:56102173..56102210,-p@chr2:56102173..56102210
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Hg19::chr2:56103806..56103824,-p@chr2:56103806..56103824
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Hg19::chr2:56104899..56104948,-p@chr2:56104899..56104948
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Hg19::chr2:56104927..56104972,+p@chr2:56104927..56104972
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Hg19::chr2:56104951..56104962,-p@chr2:56104951..56104962
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Hg19::chr2:56104999..56105010,-p@chr2:56104999..56105010
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Hg19::chr2:56108781..56108808,-p@chr2:56108781..56108808
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Hg19::chr2:56108835..56108875,-p@chr2:56108835..56108875
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Hg19::chr2:56144804..56144841,+p@chr2:56144804..56144841
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Hg19::chr2:56144851..56144902,-p@chr2:56144851..56144902
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Hg19::chr2:56144905..56144921,-p@chr2:56144905..56144921
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Hg19::chr2:56144922..56144937,+p@chr2:56144922..56144937
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Hg19::chr2:56144928..56144943,-p@chr2:56144928..56144943
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Hg19::chr2:56144945..56144975,-p@chr2:56144945..56144975
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Hg19::chr2:56145005..56145022,-p@chr2:56145005..56145022
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Hg19::chr2:56145014..56145064,+p@chr2:56145014..56145064
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Hg19::chr2:56145124..56145158,+p@chr2:56145124..56145158
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Hg19::chr2:56145348..56145379,+p@chr2:56145348..56145379
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Hg19::chr2:56149625..56149641,-p11@EFEMP1
Hg19::chr2:56149661..56149678,-p10@EFEMP1
Hg19::chr2:56150184..56150209,-p6@EFEMP1
Hg19::chr2:56150883..56150896,-p2@EFEMP1
Hg19::chr2:56150910..56150938,-p1@EFEMP1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
mesodermal cell2.99e-25121
lining cell1.04e-1858
barrier cell1.04e-1858
endothelial cell of vascular tree1.45e-1824
blood vessel endothelial cell2.80e-1318
embryonic blood vessel endothelial progenitor cell2.80e-1318
meso-epithelial cell4.14e-1345
endothelial cell1.27e-1236
embryonic cell1.30e-11250
squamous epithelial cell9.93e-1163
muscle cell4.54e-1055
muscle precursor cell6.07e-0958
myoblast6.07e-0958
multi-potent skeletal muscle stem cell6.07e-0958
fibroblast1.19e-0876
contractile cell1.34e-0859
vascular associated smooth muscle cell1.64e-0832
endothelial cell of artery2.23e-089
electrically responsive cell5.96e-0861
electrically active cell5.96e-0861
smooth muscle cell6.53e-0843
smooth muscle myoblast6.53e-0843
lymphangioblast6.23e-076
endothelial cell of lymphatic vessel6.23e-076
vascular lymphangioblast6.23e-076
cardiocyte7.51e-0716
Uber Anatomy
Ontology termp-valuen
vasculature6.81e-2778
vascular system6.81e-2778
splanchnic layer of lateral plate mesoderm3.56e-2683
cardiovascular system1.37e-24109
vessel1.51e-2468
circulatory system6.66e-24112
epithelial tube open at both ends8.06e-2259
blood vessel8.06e-2259
blood vasculature8.06e-2259
vascular cord8.06e-2259
epithelial tube8.74e-18117
artery2.23e-1742
arterial blood vessel2.23e-1742
arterial system2.23e-1742
squamous epithelium2.79e-1425
blood vessel endothelium2.80e-1318
endothelium2.80e-1318
cardiovascular system endothelium2.80e-1318
simple squamous epithelium2.40e-1222
systemic artery4.99e-1233
systemic arterial system4.99e-1233
anatomical conduit6.08e-12240
unilaminar epithelium1.57e-10148
aorta1.58e-1021
aortic system1.58e-1021
anatomical cluster2.17e-10373
tube9.29e-10192
epithelium1.45e-09306
cell layer3.73e-09309
muscle tissue1.69e-0864
musculature1.69e-0864
musculature of body1.69e-0864
endothelial tube2.23e-089
arterial system endothelium2.23e-089
endothelium of artery2.23e-089
skeletal muscle tissue4.19e-0862
striated muscle tissue4.19e-0862
myotome4.19e-0862
heart1.50e-0724
primitive heart tube1.50e-0724
primary heart field1.50e-0724
anterior lateral plate mesoderm1.50e-0724
heart tube1.50e-0724
heart primordium1.50e-0724
cardiac mesoderm1.50e-0724
cardiogenic plate1.50e-0724
heart rudiment1.50e-0724
multi-cellular organism2.75e-07656
anatomical system3.28e-07624
anatomical group4.13e-07625
primary circulatory organ9.39e-0727


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.