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Coexpression cluster:C911

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Full id: C911_cord_CD8_Natural_mycosis_Basophils_Peripheral_CD4



Phase1 CAGE Peaks

Hg19::chr16:27413488..27413517,+p1@IL21R
Hg19::chr16:27413524..27413547,+p2@IL21R
Hg19::chr16:27413589..27413601,+p5@IL21R
Hg19::chr16:27413815..27413889,+p4@IL21R
Hg19::chr17:45810594..45810608,+p1@TBX21
Hg19::chr17:45810816..45810838,+p2@TBX21
Hg19::chr3:193311668..193311697,-p@chr3:193311668..193311697
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Hg19::chr6:106968697..106968723,-p@chr6:106968697..106968723
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Hg19::chr6:90790583..90790604,-p@chr6:90790583..90790604
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Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0046649lymphocyte activation0.00107147062286589
GO:0045321leukocyte activation0.00107147062286589
GO:0001775cell activation0.00107147062286589
GO:0019977interleukin-21 binding0.00107147062286589
GO:0001532interleukin-21 receptor activity0.00107147062286589
GO:0048304positive regulation of isotype switching to IgG isotypes0.00267855827937379
GO:0048302regulation of isotype switching to IgG isotypes0.00267855827937379
GO:0048291isotype switching to IgG isotypes0.00267855827937379
GO:0045830positive regulation of isotype switching0.00357130590335091
GO:0045191regulation of isotype switching0.00420872932521112
GO:0002208somatic diversification of immunoglobulins during immune response0.00420872932521112
GO:0002381immunoglobulin production during immune response0.00420872932521112
GO:0002204somatic recombination of immunoglobulin genes during immune response0.00420872932521112
GO:0045190isotype switching0.00420872932521112
GO:0016447somatic recombination of immunoglobulin gene segments0.00438219215402637
GO:0016445somatic diversification of immunoglobulins0.00438219215402637
GO:0002562somatic diversification of immune receptors via germline recombination within a single locus0.00438219215402637
GO:0016444somatic cell DNA recombination0.00438219215402637
GO:0002200somatic diversification of immune receptors0.00438219215402637
GO:0030101natural killer cell activation0.00438219215402637
GO:0050871positive regulation of B cell activation0.00438219215402637
GO:0002377immunoglobulin production0.00438219215402637
GO:0050864regulation of B cell activation0.00582115290182016
GO:0002440production of molecular mediator of immune response0.00602471583669748
GO:0002376immune system process0.00605459280668687
GO:0004907interleukin receptor activity0.00700236669613786
GO:0019965interleukin binding0.00793226354335589
GO:0051251positive regulation of lymphocyte activation0.00927910822702546
GO:0016064immunoglobulin mediated immune response0.00927910822702546
GO:0019724B cell mediated immunity0.00927910822702546
GO:0042113B cell activation0.0105325787794911
GO:0004896hematopoietin/interferon-class (D200-domain) cytokine receptor activity0.0112655238259798
GO:0002449lymphocyte mediated immunity0.0112655238259798
GO:0002460adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains0.0112655238259798
GO:0002250adaptive immune response0.0112655238259798
GO:0051249regulation of lymphocyte activation0.0112655238259798
GO:0002443leukocyte mediated immunity0.0112655238259798
GO:0050865regulation of cell activation0.0112655238259798
GO:0050776regulation of immune response0.0130476750734828
GO:0019955cytokine binding0.0130476750734828
GO:0002682regulation of immune system process0.0130476750734828
GO:0002252immune effector process0.0140086525896998
GO:0002520immune system development0.022614900670125
GO:0006310DNA recombination0.0239171348972863
GO:0051239regulation of multicellular organismal process0.0328435206715787



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
hematopoietic cell5.76e-59182
hematopoietic stem cell7.21e-58172
angioblastic mesenchymal cell7.21e-58172
leukocyte3.58e-57140
hematopoietic oligopotent progenitor cell3.16e-54165
hematopoietic multipotent progenitor cell3.16e-54165
nongranular leukocyte9.19e-50119
hematopoietic lineage restricted progenitor cell6.60e-48124
lymphocyte7.64e-2953
common lymphoid progenitor7.64e-2953
lymphoid lineage restricted progenitor cell2.24e-2852
myeloid cell8.91e-25112
common myeloid progenitor8.91e-25112
myeloid leukocyte2.96e-2276
granulocyte monocyte progenitor cell1.24e-1971
macrophage dendritic cell progenitor1.65e-1965
myeloid lineage restricted progenitor cell1.05e-1870
monopoietic cell1.11e-1863
monocyte1.11e-1863
monoblast1.11e-1863
promonocyte1.11e-1863
mesenchymal cell3.42e-18358
connective tissue cell9.83e-17365
CD14-positive, CD16-negative classical monocyte1.09e-1642
T cell4.69e-1525
pro-T cell4.69e-1525
classical monocyte1.32e-1445
motile cell5.11e-14390
mature alpha-beta T cell1.03e-1218
alpha-beta T cell1.03e-1218
immature T cell1.03e-1218
mature T cell1.03e-1218
immature alpha-beta T cell1.03e-1218
lymphocyte of B lineage2.06e-1224
pro-B cell2.06e-1224
multi fate stem cell7.70e-12430
somatic stem cell1.34e-10436
stem cell1.51e-10444
CD8-positive, alpha-beta T cell2.36e-0811
B cell2.24e-0714
Uber Anatomy
Ontology termp-valuen
hematopoietic system4.34e-28102
blood island4.34e-28102
hemolymphoid system1.01e-23112
bone marrow1.03e-1680
bone element1.41e-1586
connective tissue1.90e-15375
immune system4.43e-12115
skeletal element2.18e-11101
skeletal system2.18e-11101
blood4.02e-1015
haemolymphatic fluid4.02e-1015
organism substance4.02e-1015
adult organism1.36e-09115
lateral plate mesoderm7.99e-07216
Disease
Ontology termp-valuen
hematologic cancer1.18e-0851
immune system cancer1.18e-0851


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.