Coexpression cluster:C1585
From FANTOM5_SSTAR
Full id: C1585_nonsmall_hepatoma_mucinous_bile_lung_Adipocyte_mature
Phase1 CAGE Peaks
| Hg19::chr10:5005598..5005621,+ | p1@AKR1C1 |
| Hg19::chr10:5060113..5060122,- | p4@AKR1C2 |
| Hg19::chr10:5060148..5060171,- | p2@AKR1C2 |
| Hg19::chr10:5060184..5060198,- | p3@AKR1C2 |
| Hg19::chr10:5136595..5136628,+ | p1@AKR1C3 |
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| p.value | FDR | nGenes | nPathway | Name |
|---|---|---|---|---|
| 7.54806151097432e-09 | 1.59264097881558e-06 | 3 | 57 | Steroid hormone biosynthesis (KEGG):00140 |
| 1.47440005351926e-08 | 2.33323808469424e-06 | 3 | 71 | Metabolism of xenobiotics by cytochrome P450 (KEGG):00980 |
| 2.16690761080603e-11 | 1.37165251764022e-08 | 3 | 9 | Benzo(a)pyrene metabolism (Wikipathways):WP696 |
| 2.26486989237789e-07 | 2.8673252837504e-05 | 3 | 175 | metapathway biotransformation (Wikipathways):WP702 |
| 1.73517139063789e-05 | 0.00183060581712297 | 3 | 740 | TGF beta receptor down reg. targets (Netpath):NetPath_7 |
| 3.43093705044287e-10 | 1.08589157646517e-07 | 3 | 21 | {POU2F1,21} (Static Module):NA |
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0047115 | trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity | 1.05602779107617e-11 |
| GO:0016628 | oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor | 2.95687781501328e-09 |
| GO:0016229 | steroid dehydrogenase activity | 1.74596594791261e-08 |
| GO:0032052 | bile acid binding | 7.17465281257153e-08 |
| GO:0047026 | 3-alpha-hydroxysteroid dehydrogenase (A-specific) activity | 7.17465281257153e-08 |
| GO:0016627 | oxidoreductase activity, acting on the CH-CH group of donors | 1.6171481578645e-07 |
| GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | 9.00496018006475e-07 |
| GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors | 9.70397137567286e-07 |
| GO:0004033 | aldo-keto reductase activity | 2.63018975102282e-06 |
| GO:0031406 | carboxylic acid binding | 3.26369824148814e-06 |
| GO:0032787 | monocarboxylic acid metabolic process | 3.74303770407995e-06 |
| GO:0006693 | prostaglandin metabolic process | 3.75179054980983e-06 |
| GO:0006692 | prostanoid metabolic process | 3.75179054980983e-06 |
| GO:0006690 | icosanoid metabolic process | 3.13595372768503e-05 |
| GO:0044255 | cellular lipid metabolic process | 5.24142597046853e-05 |
| GO:0019752 | carboxylic acid metabolic process | 5.24142597046853e-05 |
| GO:0006082 | organic acid metabolic process | 5.24142597046853e-05 |
| GO:0006629 | lipid metabolic process | 8.25175891835759e-05 |
| GO:0007586 | digestion | 8.41483072985558e-05 |
| GO:0047006 | 20-alpha-hydroxysteroid dehydrogenase activity | 0.0002877314018207 |
| GO:0047017 | prostaglandin-F synthase activity | 0.0002877314018207 |
| GO:0006631 | fatty acid metabolic process | 0.0002877314018207 |
| GO:0016491 | oxidoreductase activity | 0.0002877314018207 |
| GO:0008202 | steroid metabolic process | 0.000368383180518114 |
| GO:0047042 | 3-alpha-hydroxysteroid dehydrogenase (B-specific) activity | 0.00048744591208611 |
| GO:0047045 | testosterone 17-beta-dehydrogenase (NADP+) activity | 0.000703026292878017 |
| GO:0050327 | testosterone 17-beta-dehydrogenase activity | 0.000902624470962375 |
| GO:0015721 | bile acid and bile salt transport | 0.00108795282557785 |
| GO:0030299 | cholesterol absorption | 0.00162453274055371 |
| GO:0044241 | lipid digestion | 0.00162453274055371 |
| GO:0050892 | intestinal absorption | 0.00196504487007652 |
| GO:0015718 | monocarboxylic acid transport | 0.00257815269091689 |
| GO:0008206 | bile acid metabolic process | 0.00257815269091689 |
| GO:0042632 | cholesterol homeostasis | 0.00257815269091689 |
| GO:0055092 | sterol homeostasis | 0.00257815269091689 |
| GO:0006118 | electron transport | 0.00257815269091689 |
| GO:0055088 | lipid homeostasis | 0.00279828446182722 |
| GO:0022600 | digestive system process | 0.0030450126061026 |
| GO:0006091 | generation of precursor metabolites and energy | 0.00396795665993615 |
| GO:0006805 | xenobiotic metabolic process | 0.00471810220199635 |
| GO:0009410 | response to xenobiotic stimulus | 0.00504803476275117 |
| GO:0051260 | protein homooligomerization | 0.00594117466120264 |
| GO:0051259 | protein oligomerization | 0.00876985438476458 |
| GO:0046942 | carboxylic acid transport | 0.0133665226178137 |
| GO:0015849 | organic acid transport | 0.0133665226178137 |
| GO:0005737 | cytoplasm | 0.0160193622354137 |
| GO:0048878 | chemical homeostasis | 0.038806504830292 |
| GO:0006461 | protein complex assembly | 0.0427312690939316 |
| GO:0032501 | multicellular organismal process | 0.0494503357430177 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| fat cell | 1.53e-09 | 15 |
| muscle precursor cell | 8.23e-08 | 57 |
| myoblast | 8.23e-08 | 57 |
| multi-potent skeletal muscle stem cell | 8.23e-08 | 57 |
| muscle cell | 5.92e-07 | 54 |
| endodermal cell | 9.98e-07 | 59 |
Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
|
{{{tfbs_overrepresentation_jaspar}}} |
ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
No analysis results for this cluster
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data
This analysis result is provided for C0 - C305 clusters.
