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Coexpression cluster:C1696

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Full id: C1696_Endothelial_Renal_chronic_Lymphatic_Fibroblast_Hepatic_Mesenchymal



Phase1 CAGE Peaks

Hg19::chr12:96830523..96830532,+p@chr12:96830523..96830532
+
Hg19::chr17:8216873..8216875,+p@chr17:8216873..8216875
+
Hg19::chr7:139741849..139741879,-p12@PARP12
Hg19::chr9:139559213..139559241,+p5@EGFL7
Hg19::chr9:139563124..139563129,+p@chr9:139563124..139563129
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0001570vasculogenesis0.0370800874571462
GO:0003950NAD+ ADP-ribosyltransferase activity0.0391285678131703
GO:0016763transferase activity, transferring pentosyl groups0.0426519646402055
GO:0001525angiogenesis0.0426519646402055
GO:0048514blood vessel morphogenesis0.0426519646402055
GO:0048646anatomical structure formation0.0426519646402055
GO:0001568blood vessel development0.0426519646402055
GO:0001944vasculature development0.0426519646402055



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Uber Anatomy
Ontology termp-valuen
vessel7.64e-4669
splanchnic layer of lateral plate mesoderm7.11e-4184
vasculature3.93e-4079
vascular system3.93e-4079
blood vessel2.34e-3960
epithelial tube open at both ends2.34e-3960
blood vasculature2.34e-3960
vascular cord2.34e-3960
cardiovascular system5.69e-36110
circulatory system1.49e-34113
endothelium4.21e-3418
blood vessel endothelium4.21e-3418
cardiovascular system endothelium4.21e-3418
epithelial tube1.13e-30118
simple squamous epithelium9.30e-2722
artery1.95e-2642
arterial blood vessel1.95e-2642
arterial system1.95e-2642
squamous epithelium3.05e-2525
tube1.40e-22194
systemic artery7.12e-2133
systemic arterial system7.12e-2133
anatomical conduit1.13e-20241
aorta4.02e-1921
aortic system4.02e-1921
anatomical cluster1.32e-18286
endothelial tube7.31e-189
arterial system endothelium7.31e-189
endothelium of artery7.31e-189
unilaminar epithelium4.54e-14138
epithelium4.26e-13309
cell layer8.76e-13312
lateral plate mesoderm1.10e-12216
heart7.24e-0924
primitive heart tube7.24e-0924
primary heart field7.24e-0924
anterior lateral plate mesoderm7.24e-0924
heart tube7.24e-0924
heart primordium7.24e-0924
cardiac mesoderm7.24e-0924
cardiogenic plate7.24e-0924
heart rudiment7.24e-0924
lymphoid system8.54e-0910
lymphatic vessel1.50e-088
lymph vasculature1.50e-088
lymphatic part of lymphoid system1.50e-088
blood vessel smooth muscle4.36e-0810
arterial system smooth muscle4.36e-0810
artery smooth muscle tissue4.36e-0810
aorta smooth muscle tissue4.36e-0810
vein5.34e-089
venous blood vessel5.34e-089
venous system5.34e-089
primary circulatory organ1.53e-0727
endothelium of capillary6.48e-073
capillary6.48e-073
Disease
Ontology termp-valuen
chronic leukemia2.09e-108


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.