MCL coexpression mm9:778

Phase1 CAGE Peaks

	Short description
Mm9::chr11:115641974..115642002,+	p@chr11:115641974..115642002 +
Mm9::chr11:115642012..115642032,+	p@chr11:115642012..115642032 +
Mm9::chr14:9129624..9129650,-	p@chr14:9129624..9129650 -
Mm9::chr14:9130880..9130889,-	p@chr14:9130880..9130889 -
Mm9::chr14:9132143..9132179,-	p@chr14:9132143..9132179 -
Mm9::chr14:9142192..9142239,-	p1@Fam107a
Mm9::chr14:9142248..9142259,-	p3@Fam107a
Mm9::chr14:9142284..9142298,-	p2@Fam107a
Mm9::chr15:8660734..8660760,-	p2@Slc1a3

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0017153	sodium:dicarboxylate symporter activity	0.00821782720648661
GO:0005310	dicarboxylic acid transmembrane transporter activity	0.00821782720648661
GO:0006835	dicarboxylic acid transport	0.00821782720648661
GO:0015296	anion:cation symporter activity	0.00936832301539473
GO:0005343	organic acid:sodium symporter activity	0.00936832301539473
GO:0015370	solute:sodium symporter activity	0.0123267408097299
GO:0015294	solute:cation symporter activity	0.0123267408097299
GO:0043025	cell soma	0.0123267408097299
GO:0046943	carboxylic acid transmembrane transporter activity	0.0123267408097299
GO:0005342	organic acid transmembrane transporter activity	0.0123267408097299
GO:0046942	carboxylic acid transport	0.0123267408097299
GO:0015849	organic acid transport	0.0123267408097299
GO:0008509	anion transmembrane transporter activity	0.0212399226259961
GO:0015293	symporter activity	0.0234208075384868
GO:0015291	secondary active transmembrane transporter activity	0.0289267517668328
GO:0006605	protein targeting	0.0289678409028653
GO:0022804	active transmembrane transporter activity	0.0456814512360579
GO:0042995	cell projection	0.0498548183860187
GO:0006886	intracellular protein transport	0.0499557390710107

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
oligodendrocyte precursor cell	4.74e-07	8

Uber Anatomy

Ontology term	p-value	n
regional part of nervous system	4.22e-25	54
brain	2.74e-24	47
future brain	2.74e-24	47
central nervous system	9.21e-24	73
neural tube	2.49e-23	52
neural rod	2.49e-23	52
future spinal cord	2.49e-23	52
neural keel	2.49e-23	52
regional part of brain	2.70e-23	46
nervous system	1.05e-22	75
neurectoderm	8.03e-20	64
neural plate	8.03e-20	64
presumptive neural plate	8.03e-20	64
anterior neural tube	6.19e-19	40
ectoderm-derived structure	3.13e-18	95
ectoderm	3.13e-18	95
presumptive ectoderm	3.13e-18	95
regional part of forebrain	5.78e-18	39
forebrain	5.78e-18	39
future forebrain	5.78e-18	39
ecto-epithelium	1.25e-17	73
pre-chordal neural plate	6.07e-17	49
structure with developmental contribution from neural crest	1.01e-15	92
brain grey matter	5.05e-13	29
regional part of telencephalon	5.05e-13	29
telencephalon	5.05e-13	29
regional part of cerebral cortex	6.17e-13	17
occipital lobe	1.06e-12	10
visual cortex	1.06e-12	10
neocortex	1.06e-12	10
gray matter	2.92e-12	34
cerebral cortex	2.57e-11	21
cerebral hemisphere	2.57e-11	21
pallium	2.57e-11	21
tube	2.01e-08	114
anatomical conduit	4.37e-08	122

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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