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Coexpression cluster:C3667

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Full id: C3667_Natural_CD8_CD4_Basophils_Peripheral_CD14_adipose



Phase1 CAGE Peaks

Hg19::chr17:65373583..65373610,+p3@PITPNC1
Hg19::chr17:65374075..65374129,+p4@PITPNC1
Hg19::chr17:65374895..65374909,-p@chr17:65374895..65374909
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Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
leukocyte5.01e-25140
nongranular leukocyte1.44e-23119
CD14-positive, CD16-negative classical monocyte7.81e-2142
hematopoietic lineage restricted progenitor cell4.25e-20124
classical monocyte1.61e-1945
hematopoietic stem cell2.06e-16172
angioblastic mesenchymal cell2.06e-16172
myeloid leukocyte9.05e-1676
hematopoietic oligopotent progenitor cell1.66e-15165
hematopoietic multipotent progenitor cell1.66e-15165
hematopoietic cell4.87e-14182
monopoietic cell8.62e-1363
monocyte8.62e-1363
monoblast8.62e-1363
promonocyte8.62e-1363
mature alpha-beta T cell8.68e-1318
alpha-beta T cell8.68e-1318
immature T cell8.68e-1318
mature T cell8.68e-1318
immature alpha-beta T cell8.68e-1318
granulocyte monocyte progenitor cell2.40e-1271
macrophage dendritic cell progenitor3.60e-1265
T cell2.01e-1125
pro-T cell2.01e-1125
myeloid lineage restricted progenitor cell3.05e-1170
lymphoid lineage restricted progenitor cell7.35e-1052
lymphocyte1.40e-0953
common lymphoid progenitor1.40e-0953
CD8-positive, alpha-beta T cell1.22e-0811
myeloid cell2.99e-07112
common myeloid progenitor2.99e-07112
Uber Anatomy
Ontology termp-valuen
adult organism3.72e-23115
hematopoietic system7.88e-17102
blood island7.88e-17102
hemolymphoid system8.59e-17112
bone marrow3.74e-1080
neural tube1.02e-0957
neural rod1.02e-0957
future spinal cord1.02e-0957
neural keel1.02e-0957
immune system1.27e-09115
bone element3.37e-0986
skeletal element1.09e-08101
skeletal system1.09e-08101
anterior neural tube2.69e-0742
gray matter4.76e-0734
brain grey matter4.76e-0734
regional part of forebrain6.45e-0741
forebrain6.45e-0741
future forebrain6.45e-0741
telencephalon8.75e-0734


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.