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Coexpression cluster:C4087: Difference between revisions

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|tf_chipseq_enrich=CHD2#1106;3:10.3440228341169:0.000903370110274688:0.00661203104260832!E2F1#1869;3:4.90738921487932:0.00846098534723939:0.0325976408691285!E2F6#1876;3:5.01715573169739:0.0079176980688633:0.0322938556828092!EBF1#1879;3:8.906466846569:0.0014152328356098:0.00916452766110196!ELF1#1997;3:4.25809795880754:0.0129517987505461:0.0463212420282269!ESR1#2099;3:30.7686032961545:3.43136389821584e-05:0.000677829041357601!HDAC2#3066;3:13.4156202366263:0.000414076139985721:0.00391895767865598!HNF4A#3172;3:23.1322903629537:8.07584663437677e-05:0.00122931547390712!HNF4G#3174;3:28.7534225264468:4.20470658818262e-05:0.00075765243506419!IRF1#3659;3:7.6371637535639:0.00224469274729724:0.0128323096959317!MXI1#4601;3:9.9615716287593:0.00101147054125902:0.00721169933496388!NANOG#79923;3:29.2447784810127:3.99627955670032e-05:0.000738311410971564!RXRA#6256;3:20.0746171391333:0.000123573034843222:0.00165417126198299!SIN3A#25942;3:5.40888472681514:0.00631896197799152:0.0277299915971031!SP1#6667;3:5.6983813781409:0.00540396270171217:0.0246984578619805!SREBF1#6720;3:47.0058494404883:9.62099323994382e-06:0.000254897745557203!USF1#7391;3:6.36149927720796:0.0038840405729056:0.0190658635736834!YY1#7528;3:4.91117074985386:0.00844145534180826:0.0329971238282474
|tf_chipseq_enrich=CHD2#1106;3:10.3440228341169:0.000903370110274688:0.00661203104260832!E2F1#1869;3:4.90738921487932:0.00846098534723939:0.0325976408691285!E2F6#1876;3:5.01715573169739:0.0079176980688633:0.0322938556828092!EBF1#1879;3:8.906466846569:0.0014152328356098:0.00916452766110196!ELF1#1997;3:4.25809795880754:0.0129517987505461:0.0463212420282269!ESR1#2099;3:30.7686032961545:3.43136389821584e-05:0.000677829041357601!HDAC2#3066;3:13.4156202366263:0.000414076139985721:0.00391895767865598!HNF4A#3172;3:23.1322903629537:8.07584663437677e-05:0.00122931547390712!HNF4G#3174;3:28.7534225264468:4.20470658818262e-05:0.00075765243506419!IRF1#3659;3:7.6371637535639:0.00224469274729724:0.0128323096959317!MXI1#4601;3:9.9615716287593:0.00101147054125902:0.00721169933496388!NANOG#79923;3:29.2447784810127:3.99627955670032e-05:0.000738311410971564!RXRA#6256;3:20.0746171391333:0.000123573034843222:0.00165417126198299!SIN3A#25942;3:5.40888472681514:0.00631896197799152:0.0277299915971031!SP1#6667;3:5.6983813781409:0.00540396270171217:0.0246984578619805!SREBF1#6720;3:47.0058494404883:9.62099323994382e-06:0.000254897745557203!USF1#7391;3:6.36149927720796:0.0038840405729056:0.0190658635736834!YY1#7528;3:4.91117074985386:0.00844145534180826:0.0329971238282474
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}}
}}

Revision as of 16:32, 26 November 2012


Full id: C4087_Mesenchymal_Adipocyte_Alveolar_Hair_Renal_Fibroblast_Pericytes



Phase1 CAGE Peaks

Hg19::chr22:19166235..19166238,-p4@SLC25A1
Hg19::chr22:19166241..19166257,-p1@SLC25A1
Hg19::chr22:19166269..19166306,-p2@SLC25A1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
mesenchyme1.06e-20160
entire embryonic mesenchyme1.06e-20160
organism subdivision4.41e-20264
epithelial vesicle3.84e-1978
trunk mesenchyme4.54e-18122
unilaminar epithelium9.29e-18148
trunk2.93e-17199
epithelial tube3.01e-17117
somite3.83e-1671
presomitic mesoderm3.83e-1671
presumptive segmental plate3.83e-1671
dermomyotome3.83e-1671
trunk paraxial mesoderm3.83e-1671
multilaminar epithelium8.30e-1683
paraxial mesoderm2.03e-1572
presumptive paraxial mesoderm2.03e-1572
dense mesenchyme tissue2.08e-1573
vasculature1.13e-1378
vascular system1.13e-1378
multi-tissue structure4.49e-13342
muscle tissue7.13e-1364
musculature7.13e-1364
musculature of body7.13e-1364
skeletal muscle tissue8.93e-1362
striated muscle tissue8.93e-1362
myotome8.93e-1362
cell layer3.19e-11309
splanchnic layer of lateral plate mesoderm6.83e-1183
epithelium8.36e-11306
epithelial tube open at both ends8.76e-1059
blood vessel8.76e-1059
blood vasculature8.76e-1059
vascular cord8.76e-1059
vessel1.11e-0968
anatomical cluster5.64e-09373
artery1.38e-0842
arterial blood vessel1.38e-0842
arterial system1.38e-0842
subdivision of trunk1.45e-08112
nephron epithelium1.86e-0815
renal tubule1.86e-0815
nephron tubule1.86e-0815
nephron1.86e-0815
uriniferous tubule1.86e-0815
nephrogenic mesenchyme1.86e-0815
excretory tube7.84e-0816
kidney epithelium7.84e-0816
abdominal segment of trunk1.23e-0760
abdomen1.23e-0760
cardiovascular system1.76e-07109
urinary system structure3.64e-0747
ectodermal placode4.10e-0731
primordium4.43e-07160
abdomen element6.19e-0754
abdominal segment element6.19e-0754
renal system6.69e-0748
cortex of kidney6.96e-0712
renal parenchyma6.96e-0712
endoderm-derived structure7.43e-07160
endoderm7.43e-07160
presumptive endoderm7.43e-07160
circulatory system8.28e-07112
systemic artery9.54e-0733
systemic arterial system9.54e-0733


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CHD2#1106310.34402283411690.0009033701102746880.00661203104260832
E2F1#186934.907389214879320.008460985347239390.0325976408691285
E2F6#187635.017155731697390.00791769806886330.0322938556828092
EBF1#187938.9064668465690.00141523283560980.00916452766110196
ELF1#199734.258097958807540.01295179875054610.0463212420282269
ESR1#2099330.76860329615453.43136389821584e-050.000677829041357601
HDAC2#3066313.41562023662630.0004140761399857210.00391895767865598
HNF4A#3172323.13229036295378.07584663437677e-050.00122931547390712
HNF4G#3174328.75342252644684.20470658818262e-050.00075765243506419
IRF1#365937.63716375356390.002244692747297240.0128323096959317
MXI1#460139.96157162875930.001011470541259020.00721169933496388
NANOG#79923329.24477848101273.99627955670032e-050.000738311410971564
RXRA#6256320.07461713913330.0001235730348432220.00165417126198299
SIN3A#2594235.408884726815140.006318961977991520.0277299915971031
SP1#666735.69838137814090.005403962701712170.0246984578619805
SREBF1#6720347.00584944048839.62099323994382e-060.000254897745557203
USF1#739136.361499277207960.00388404057290560.0190658635736834
YY1#752834.911170749853860.008441455341808260.0329971238282474



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.