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Coexpression cluster:C616

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Full id: C616_CD14_Natural_CD8_Basophils_Mast_Eosinophils_CD4



Phase1 CAGE Peaks

Hg19::chr10:70716856..70716871,-p@chr10:70716856..70716871
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Hg19::chr11:65189036..65189061,+p@chr11:65189036..65189061
+
Hg19::chr12:3982744..3982748,+p@chr12:3982744..3982748
+
Hg19::chr12:9917411..9917425,-p@chr12:9917411..9917425
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Hg19::chr13:41557163..41557168,+p@chr13:41557163..41557168
+
Hg19::chr17:40540898..40540910,+p@chr17:40540898..40540910
+
Hg19::chr19:14485996..14486000,-p@chr19:14485996..14486000
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Hg19::chr20:1305835..1305872,-p@chr20:1305835..1305872
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Hg19::chr2:145275236..145275249,+p@chr2:145275236..145275249
+
Hg19::chr4:103790462..103790537,+p4@CISD2
Hg19::chr5:43018230..43018260,+p1@ENST00000509036
Hg19::chr7:644391..644410,+p@chr7:644391..644410
+
Hg19::chr8:29940840..29940888,+p@chr8:29940840..29940888
+
Hg19::chr9:132890689..132890715,+p@chr9:132890689..132890715
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
hematopoietic cell1.61e-53182
hematopoietic stem cell8.61e-53172
angioblastic mesenchymal cell8.61e-53172
leukocyte6.95e-52140
hematopoietic oligopotent progenitor cell3.56e-49165
hematopoietic multipotent progenitor cell3.56e-49165
hematopoietic lineage restricted progenitor cell4.31e-44124
nongranular leukocyte1.00e-40119
myeloid cell3.56e-29112
common myeloid progenitor3.56e-29112
myeloid leukocyte9.97e-2876
CD14-positive, CD16-negative classical monocyte7.34e-2642
classical monocyte9.24e-2645
granulocyte monocyte progenitor cell1.48e-2471
myeloid lineage restricted progenitor cell7.23e-2470
macrophage dendritic cell progenitor1.75e-2165
monopoietic cell1.34e-2063
monocyte1.34e-2063
monoblast1.34e-2063
promonocyte1.34e-2063
connective tissue cell1.48e-19365
mesenchymal cell6.19e-19358
lymphoid lineage restricted progenitor cell3.56e-1852
lymphocyte9.85e-1853
common lymphoid progenitor9.85e-1853
motile cell6.54e-14390
multi fate stem cell8.13e-13430
somatic stem cell5.97e-12436
stem cell8.05e-12444
mature alpha-beta T cell2.17e-1018
alpha-beta T cell2.17e-1018
immature T cell2.17e-1018
mature T cell2.17e-1018
immature alpha-beta T cell2.17e-1018
T cell1.63e-0925
pro-T cell1.63e-0925
lymphocyte of B lineage3.99e-0824
pro-B cell3.99e-0824
CD8-positive, alpha-beta T cell7.45e-0711
B cell8.41e-0714
Uber Anatomy
Ontology termp-valuen
hematopoietic system4.71e-33102
blood island4.71e-33102
hemolymphoid system2.32e-31112
bone marrow6.30e-2580
bone element1.59e-2286
connective tissue4.81e-19375
immune system2.51e-18115
skeletal element3.50e-17101
skeletal system3.50e-17101
lateral plate mesoderm3.40e-08216
blood4.47e-0715
haemolymphatic fluid4.47e-0715
organism substance4.47e-0715


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BATF#1053858.699214925822730.0001707317014125790.00208306637427901
BCL11A#5333536.079168950772940.01190171164357230.0433117133817572
BCLAF1#977446.18647074574910.003132529788682840.0164492070290234
CEBPB#105184.554941500471329.08334040436614e-050.00132475211351989
E2F1#186972.453694607439660.01287341320003250.0463104988012605
E2F6#187672.508577865848690.01138806613187710.0417347967838835
EBF1#187985.089409626610864.04144399024511e-050.000739849901660314
EGR1#195882.850388054177220.00243469412076630.0137106124921121
ELF1#1997103.041498542005380.0001960883233653430.00235827595623595
ELK4#200544.638766188133720.008733913817853870.0331827722078955
ESR1#209936.593272134890250.009544258879732140.0359437780592942
FAM48A#55578182.51205357142860.01205190378031250.0437424423601063
FOS#235363.856266560954750.002556261076114450.0141442834716989
FOSL2#235544.837200172731910.007541622873992410.0310902167575943
GATA1#262376.780154071900222.55304819429845e-050.000552617202827639
GATA2#262454.551761333412140.003254844206293050.0168592309706413
GTF2F1#296254.54987888455630.003260749591375690.0168864693099462
HEY1#2346292.597214241996530.00199645482507470.0116095626657002
HSF1#3297223.47009523809520.003208762592628910.0168283597675791
IRF4#366246.261289339069750.002998943887654680.0159384611817601
JUN#372576.256414596168174.30563398722854e-050.000768151875627197
JUNB#3726510.9323688070795.80714990876497e-050.00096621463967103
JUND#372773.497331970935510.001654921271857660.0103477412866876
MAX#4149104.608968220719374.35925428810888e-060.000136596507229464
MEF2A#420545.355208831326870.005261339689734130.0243708278642898
MXI1#460164.269244983753980.001503425481111480.00960344060072182
MYC#4609103.730201336863863.09172673265338e-050.000626497571268114
NFKB1#479083.136036242396480.00127269626490260.00853522925641575
NR3C1#290844.278006666049440.01156838455163820.0422858222801532
NRF1#489954.360814088468180.003924918866440580.0191236109863395
PAX5#507994.287577841471463.71976426636989e-050.0007180932721172
POLR2A#5430142.147453176558072.25331953374171e-050.000492743799799937
POU2F2#545295.853936894263052.76328769641543e-069.56562823088933e-05
RFX5#599365.163390354512180.0005456302422474930.00471223657240436
SMARCC1#659939.356434139921030.003615975788529630.0183022630308348
SMARCC2#6601213.45076777527110.009425839501767180.0355606419725124
SMC3#912644.298552241409380.01137870676951730.0417048870433976
SP1#666793.663245171662010.0001341814525306330.00175964047223088
STAT3#677453.756951784697940.007450706951958610.030734828318019
TAL1#688636.400417859451470.01034886259116140.0384334279268299
TBP#6908123.177232017511197.62532496869237e-060.000217412316244953
TCF12#693853.798023179352290.00711439682790230.0296236540271625
USF1#739173.180749638603980.002913753057932640.0157453021998979
USF2#739254.640070494667710.002991628438887930.0159036283482142
YY1#752872.455585374926930.01281875463892510.046117048423517



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.