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Coexpression cluster:C1281

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Full id: C1281_Smooth_Fibroblast_Adipocyte_Olfactory_leiomyoma_Preadipocyte_tenocyte



Phase1 CAGE Peaks

Hg19::chr7:128394431..128394448,+p@chr7:128394431..128394448
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Hg19::chr7:128399002..128399018,+p4@CALU
Hg19::chr7:128399025..128399043,+p@chr7:128399025..128399043
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Hg19::chr7:128399054..128399065,+p@chr7:128399054..128399065
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Hg19::chr7:128409190..128409213,+p@chr7:128409190..128409213
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Hg19::chr7:128409381..128409428,+p@chr7:128409381..128409428
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Hg19::chr7:128410484..128410495,+p@chr7:128410484..128410495
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Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Uber Anatomy
Ontology termp-valuen
somite8.11e-1683
paraxial mesoderm8.11e-1683
presomitic mesoderm8.11e-1683
presumptive segmental plate8.11e-1683
trunk paraxial mesoderm8.11e-1683
presumptive paraxial mesoderm8.11e-1683
dermomyotome1.35e-1470
skeletal muscle tissue1.59e-1361
striated muscle tissue1.59e-1361
myotome1.59e-1361
multilaminar epithelium3.36e-1382
muscle tissue5.52e-1363
musculature5.52e-1363
musculature of body5.52e-1363
trunk mesenchyme2.38e-11143
splanchnic layer of lateral plate mesoderm4.45e-1184
artery6.15e-1142
arterial blood vessel6.15e-1142
arterial system6.15e-1142
unilaminar epithelium3.00e-10138
integument1.46e-0945
integumental system1.46e-0945
blood vessel2.76e-0960
epithelial tube open at both ends2.76e-0960
blood vasculature2.76e-0960
vascular cord2.76e-0960
vasculature3.95e-0979
vascular system3.95e-0979
systemic artery4.47e-0933
systemic arterial system4.47e-0933
surface structure1.84e-0895
vessel2.18e-0869
trunk3.07e-08216
skin of body3.60e-0840
epithelial tube7.71e-08118
circulatory system6.29e-07113
cardiovascular system7.56e-07110
Disease
Ontology termp-valuen
ovarian cancer1.20e-0814


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
MAFF#23764324.13515278140510.0001855919461545370.00224678767409686
MAFK#7975311.61459991621280.001571626617440920.00996594488760853



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.