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Coexpression cluster:C1644

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Full id: C1644_Neutrophils_Eosinophils_medial_amygdala_frontal_paracentral_insula



Phase1 CAGE Peaks

  Short description
Hg19::chr11:77122928..77123045,- p1@PAK1
Hg19::chr12:90103081..90103155,- p2@ATP2B1
Hg19::chr14:71788096..71788143,+ p3@SIPA1L1
Hg19::chr7:26331560..26331647,+ p1@SNX10
Hg19::chr7:26331652..26331663,+ p7@SNX10


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data


Cell Type
Ontology termp-valuen
leukocyte1.59e-37136
nongranular leukocyte5.66e-32115
hematopoietic lineage restricted progenitor cell1.53e-31120
hematopoietic oligopotent progenitor cell5.94e-31161
hematopoietic multipotent progenitor cell5.94e-31161
hematopoietic stem cell1.17e-30168
angioblastic mesenchymal cell1.17e-30168
myeloid leukocyte1.55e-2972
hematopoietic cell8.53e-26177
granulocyte monocyte progenitor cell1.03e-2567
macrophage dendritic cell progenitor5.88e-2561
classical monocyte1.04e-2442
CD14-positive, CD16-negative classical monocyte1.04e-2442
monopoietic cell3.31e-2459
monocyte3.31e-2459
monoblast3.31e-2459
promonocyte3.31e-2459
defensive cell3.36e-2448
phagocyte3.36e-2448
myeloid lineage restricted progenitor cell6.30e-2466
myeloid cell2.45e-22108
common myeloid progenitor2.45e-22108
lymphocyte3.41e-0853
common lymphoid progenitor3.41e-0853
lymphoid lineage restricted progenitor cell3.96e-0852
nucleate cell6.32e-0855
lymphocyte of B lineage4.09e-0724
pro-B cell4.09e-0724
Uber Anatomy
Ontology termp-valuen
hematopoietic system6.21e-2798
blood island6.21e-2798
bone marrow3.74e-2376
bone element3.95e-2282
hemolymphoid system7.01e-21108
skeletal element2.09e-1990
immune system3.31e-1793
skeletal system4.12e-17100
neural tube3.72e-1656
neural rod3.72e-1656
future spinal cord3.72e-1656
neural keel3.72e-1656
regional part of nervous system3.03e-1553
regional part of brain3.03e-1553
regional part of forebrain3.81e-1541
forebrain3.81e-1541
anterior neural tube3.81e-1541
future forebrain3.81e-1541
central nervous system7.55e-1481
telencephalon2.12e-1334
brain grey matter3.47e-1334
gray matter3.47e-1334
cerebral hemisphere3.78e-1332
regional part of telencephalon1.41e-1232
nervous system3.41e-1289
brain4.56e-1268
future brain4.56e-1268
regional part of cerebral cortex1.55e-1122
adult organism1.04e-10114
neocortex1.54e-1020
cerebral cortex2.85e-0925
pallium2.85e-0925
musculoskeletal system1.47e-08167


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.12.24383
MA0004.10.626788
MA0006.10.452993
MA0007.10.606704
MA0009.11.11255
MA0014.11.45664
MA0017.10.496101
MA0019.10.784036
MA0024.11.00439
MA0025.11.24931
MA0027.12.73598
MA0028.10.470679
MA0029.11.02437
MA0030.11.01252
MA0031.10.945567
MA0038.10.736268
MA0040.11.03042
MA0041.10.64667
MA0042.10.612397
MA0043.11.11288
MA0046.11.10134
MA0048.11.08193
MA0050.11.48918
MA0051.10.731787
MA0052.11.03442
MA0055.10.603517
MA0056.10
MA0057.10.189508
MA0058.11.29981
MA0059.10.522232
MA0060.10.321781
MA0061.10.791444
MA0063.10
MA0066.10.736721
MA0067.11.43651
MA0068.10.247962
MA0069.11.09737
MA0070.11.08584
MA0071.10.695094
MA0072.11.0812
MA0073.10.0140295
MA0074.10.730989
MA0076.10.540943
MA0077.11.07324
MA0078.10.836493
MA0081.10.522409
MA0083.11.12028
MA0084.11.62584
MA0087.11.07867
MA0088.11.92154
MA0089.10
MA0090.10.556637
MA0091.10.629594
MA0092.10.588959
MA0093.11.15584
MA0095.10
MA0098.10
MA0100.10.750974
MA0101.11.16366
MA0103.10.442769
MA0105.11.00065
MA0106.10.779931
MA0107.10.985964
MA0108.20.94238
MA0109.10
MA0111.10.5713
MA0113.10.797251
MA0114.10.372523
MA0115.11.35895
MA0116.10.382106
MA0117.11.1512
MA0119.10.504689
MA0122.11.17777
MA0124.11.31673
MA0125.11.23103
MA0130.10
MA0131.11.99092
MA0132.10
MA0133.10
MA0135.11.14377
MA0136.10.743749
MA0139.11.39016
MA0140.10.692258
MA0141.10.520334
MA0142.10.912455
MA0143.10.797437
MA0144.10.356507
MA0145.11.39943
MA0146.10.6031
MA0147.10.386018
MA0148.10.653474
MA0149.12.7505
MA0062.20.284987
MA0035.20.691506
MA0039.20.801354
MA0138.20.837782
MA0002.20.83106
MA0137.20.47779
MA0104.20.858845
MA0047.20.767096
MA0112.20.136971
MA0065.20.449243
MA0150.10.550239
MA0151.10
MA0152.10.69926
MA0153.11.21379
MA0154.10.514087
MA0155.10.813062
MA0156.10.480289
MA0157.10.883854
MA0158.10
MA0159.11.00463
MA0160.10.669748
MA0161.10
MA0162.13.53221
MA0163.11.05321
MA0164.10.810347
MA0080.20.456437
MA0018.20.781393
MA0099.20.699641
MA0079.20.823998
MA0102.21.66336
MA0258.10.345771
MA0259.11.02361
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CTCF#1066455.360256373075030.0002259278299937090.00249452126405676
E2F1#186954.907389214879320.0003512818099256460.00352256562139458
E2F6#187644.013724585357910.006632118233933880.0282888215737725
EGR1#195843.990543275848110.0067800983001440.0287579371469252
ELF1#199743.406478367046030.01235066105299550.0447257520705199
PAX5#507956.669565531177837.57493746384605e-050.0011692564200216
RAD21#588548.284027116365060.0004011622639122450.00386539216539634
SMARCB1#6598310.95162946869440.001511872848343180.00965031710109483
SMC3#912639.02695970695970.002650964449467550.0146341813065142
ZEB1#6935310.13305921052630.001895556924357070.0111595304184289



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.