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Coexpression cluster:C2691

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Full id: C2691_migratory_CD14_splenic_myelodysplastic_immature_acute_Dendritic



Phase1 CAGE Peaks

  Short description
Hg19::chr2:232047395..232047400,- -
p@chr2:232047395..232047400
Hg19::chr2:232047415..232047450,- -
p@chr2:232047415..232047450
Hg19::chr2:232047454..232047457,- p@chr2:232047454..232047457
-
Hg19::chr9:134610968..134610980,- p@chr9:134610968..134610980
-


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data


Cell Type
Ontology termp-valuen
macrophage dendritic cell progenitor1.19e-6761
monopoietic cell1.33e-6259
monocyte1.33e-6259
monoblast1.33e-6259
promonocyte1.33e-6259
granulocyte monocyte progenitor cell1.05e-6067
defensive cell8.48e-6048
phagocyte8.48e-6048
myeloid lineage restricted progenitor cell5.94e-5566
myeloid cell1.29e-54108
common myeloid progenitor1.29e-54108
classical monocyte3.77e-5342
CD14-positive, CD16-negative classical monocyte3.77e-5342
myeloid leukocyte1.96e-5272
leukocyte2.38e-40136
hematopoietic oligopotent progenitor cell3.25e-39161
hematopoietic multipotent progenitor cell3.25e-39161
hematopoietic stem cell9.80e-39168
angioblastic mesenchymal cell9.80e-39168
hematopoietic lineage restricted progenitor cell1.92e-36120
nongranular leukocyte3.13e-36115
hematopoietic cell4.24e-36177
stuff accumulating cell7.99e-2987
conventional dendritic cell1.96e-218
dendritic cell3.00e-1710
Langerhans cell3.16e-165
mesenchymal cell5.71e-13354
immature conventional dendritic cell8.81e-135
common dendritic progenitor8.81e-135
connective tissue cell1.84e-12361
motile cell1.11e-10386
multi fate stem cell4.05e-09427
somatic stem cell8.24e-09433
stem cell2.05e-08441
macrophage7.53e-086
CD1a-positive Langerhans cell2.70e-072
immature CD1a-positive Langerhans cell2.70e-072
Uber Anatomy
Ontology termp-valuen
bone marrow2.55e-5276
bone element9.66e-4882
immune system1.25e-4593
hematopoietic system7.71e-4398
blood island7.71e-4398
skeletal element1.40e-4290
hemolymphoid system7.68e-40108
skeletal system2.78e-37100
musculoskeletal system2.51e-19167
lateral plate mesoderm4.13e-15203
connective tissue1.63e-12371
mesoderm2.89e-07315
mesoderm-derived structure2.89e-07315
presumptive mesoderm2.89e-07315


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0214529
MA0004.12.8475
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.10.0695829
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.11.92746
MA0040.11.12314
MA0041.11.73823
MA0042.11.66514
MA0043.11.20635
MA0046.11.19471
MA0048.10.25531
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.10.125954
MA0056.10
MA0057.10.248209
MA0058.14.90963
MA0059.12.50216
MA0060.13.69367
MA0061.10.360128
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.12.64938
MA0071.10.782546
MA0072.11.1744
MA0073.10.100363
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.13.51802
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.10.182167
MA0089.10
MA0090.11.54523
MA0091.10.715356
MA0092.10.673508
MA0093.12.27878
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.10.539569
MA0103.11.29536
MA0105.10.232357
MA0106.10.869173
MA0107.10.453492
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.11.13665
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.12.17614
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.11.63368
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.10.430413
MA0145.11.08195
MA0146.10.061409
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.20.0247757
MA0138.20.928035
MA0002.20.379056
MA0137.20.558189
MA0104.21.01696
MA0047.20.856092
MA0112.20.187982
MA0065.20.199162
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.10.229241
MA0155.10.180766
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.10.0928415
MA0163.10.0725493
MA0164.10.90014
MA0080.21.32578
MA0018.20.870662
MA0099.20.7872
MA0079.20.000248021
MA0102.21.75932
MA0258.10.418966
MA0259.11.1888
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
FOS#235348.99795530889440.0001525147711168630.00195106445133195
MAX#414934.839416631755340.01315737137836840.0466380229902733
NFYA#4800313.81918552487290.0006132411806734510.00508909778850652
NFYB#4801312.56984494015230.000811456397697350.00619138623020993
USF1#739146.361499277207960.0006105011399140830.00508494525492359
USF2#739239.74414803880220.001718341848410070.010723746896092



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.