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Coexpression cluster:C381

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Full id: C381_Endothelial_Renal_Hepatic_Lymphatic_Fibroblast_squamous_esophagus



Phase1 CAGE Peaks

  Short description
Hg19::chr10:50153703..50153720,+ p7@WDFY4
Hg19::chr10:50153735..50153750,+ p6@WDFY4
Hg19::chr11:19138741..19138756,+ p2@ZDHHC13
Hg19::chr12:105863636..105863650,+ p@chr12:105863636..105863650
+
Hg19::chr12:105863654..105863682,+ +
p@chr12:105863654..105863682
Hg19::chr12:105863705..105863718,+ p@chr12:105863705..105863718
+
Hg19::chr12:118112251..118112272,- p12@KSR2
Hg19::chr12:96830430..96830450,+ p@chr12:96830430..96830450
+
Hg19::chr13:32835894..32835907,+ p@chr13:32835894..32835907
+
Hg19::chr13:32835912..32835936,+ p@chr13:32835912..32835936
+
Hg19::chr13:32838801..32838818,+ p9@FRY
Hg19::chr13:32838839..32838850,+ p20@FRY
Hg19::chr15:39423060..39423066,+ p@chr15:39423060..39423066
+
Hg19::chr15:39542867..39542890,+ p1@C15orf54
Hg19::chr18:33046982..33046991,- p@chr18:33046982..33046991
-
Hg19::chr18:33047039..33047063,- p@chr18:33047039..33047063
-
Hg19::chr18:33047076..33047099,- p@chr18:33047076..33047099
-
Hg19::chr18:33047117..33047138,- p@chr18:33047117..33047138
-
Hg19::chr18:33047157..33047168,- p@chr18:33047157..33047168
-
Hg19::chr2:216713591..216713606,- p@chr2:216713591..216713606
-
Hg19::chr2:56216687..56216727,- p1@MIR216A
Hg19::chr2:56216738..56216739,- p@chr2:56216738..56216739
-
Hg19::chr4:11545590..11545602,+ p@chr4:11545590..11545602
+
Hg19::chr5:71853090..71853107,+ p@chr5:71853090..71853107
+
Hg19::chr5:95920642..95920681,+ p1@ENST00000513158
Hg19::chr7:106720036..106720059,- p@chr7:106720036..106720059
-
Hg19::chr7:139741594..139741615,- p5@PARP12
Hg19::chrX:15518894..15518905,+ p2@BMX


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data


Cell Type
Ontology termp-valuen
endothelial cell of vascular tree4.71e-13624
endothelial cell1.58e-13036
meso-epithelial cell2.42e-10345
blood vessel endothelial cell3.17e-10318
embryonic blood vessel endothelial progenitor cell3.17e-10318
lining cell5.90e-7958
barrier cell5.90e-7958
endothelial cell of artery4.44e-529
mesodermal cell1.35e-37121
vein endothelial cell4.09e-366
aortic endothelial cell1.42e-356
lymphangioblast1.25e-336
endothelial cell of lymphatic vessel1.25e-336
vascular lymphangioblast1.25e-336
squamous epithelial cell1.03e-2663
endothelial cell of umbilical vein3.98e-193
capillary endothelial cell6.73e-183
embryonic cell5.06e-15250
epithelial cell1.03e-13253
thoracic aorta endothelial cell5.96e-132
endothelial cell of sinusoid3.84e-122
endothelial cell of hepatic sinusoid3.84e-122
fenestrated cell9.56e-115
glomerular endothelial cell9.56e-115
glomerular cell8.26e-087
kidney corpuscule cell8.26e-087
Uber Anatomy
Ontology termp-valuen
blood vessel endothelium3.17e-10318
endothelium3.17e-10318
cardiovascular system endothelium3.17e-10318
simple squamous epithelium9.18e-8422
squamous epithelium2.99e-7325
vessel3.32e-5768
endothelial tube4.44e-529
arterial system endothelium4.44e-529
endothelium of artery4.44e-529
vasculature3.49e-4978
vascular system3.49e-4978
epithelial tube open at both ends1.68e-3959
blood vessel1.68e-3959
blood vasculature1.68e-3959
vascular cord1.68e-3959
cardiovascular system3.06e-39109
circulatory system4.88e-38112
splanchnic layer of lateral plate mesoderm2.06e-3283
epithelial tube2.42e-28117
lymphatic vessel4.10e-258
lymph vasculature4.10e-258
lymphatic part of lymphoid system4.10e-258
vein6.59e-249
venous blood vessel6.59e-249
venous system6.59e-249
lymphoid system5.37e-2010
anatomical conduit9.38e-19240
microcirculatory vessel6.73e-183
endothelium of capillary6.73e-183
capillary6.73e-183
tube4.52e-15192
unilaminar epithelium1.69e-14148
lateral plate mesoderm5.73e-14203
segment of aorta5.96e-132
thoracic aorta5.96e-132
artery3.14e-1242
arterial blood vessel3.14e-1242
arterial system3.14e-1242
hepatic sinusoid3.84e-122
abdomen blood vessel3.84e-122
sinusoid3.84e-122
abdominal segment blood vessel3.84e-122
umbilical vein1.12e-115
umbilical blood vessel8.31e-119
anatomical cluster1.06e-10373
aorta9.19e-1021
aortic system9.19e-1021
parenchyma3.40e-0915
mesoderm8.92e-09315
mesoderm-derived structure8.92e-09315
presumptive mesoderm8.92e-09315
liver parenchyma2.19e-083
liver lobule2.19e-083
hepatic duct2.19e-083
epithelium2.54e-08306
cell layer3.46e-08309
primitive nephron8.26e-087
renal glomerulus8.26e-087
renal corpuscle8.26e-087
glomerular capsule8.26e-087
metanephric mesenchyme8.26e-087
glomerular tuft8.26e-087
S-shaped body8.26e-087
renal vesicle8.26e-087
comma-shaped body8.26e-087
duct3.28e-0719
mesonephric epithelium6.91e-078
mesonephric tubule6.91e-078
nephric duct6.91e-078
renal duct6.91e-078
mesonephric duct6.91e-078
pronephric duct6.91e-078


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.12.70285e-06
MA0004.10.351577
MA0006.10.0399016
MA0007.11.63451
MA0009.10.441048
MA0014.19.72827e-06
MA0017.10.0536635
MA0019.10.197704
MA0024.10.354374
MA0025.10.557187
MA0027.11.98963
MA0028.10.0452766
MA0029.10.967833
MA0030.10.360703
MA0031.10.309631
MA0038.10.503116
MA0040.10.374747
MA0041.10.377723
MA0042.11.12861
MA0043.10.441316
MA0046.11.10289
MA0048.10.0100542
MA0050.10.102063
MA0051.10.165625
MA0052.10.377904
MA0055.10.0368303
MA0056.10
MA0057.10.00128881
MA0058.10.22757
MA0059.10.226028
MA0060.10.153741
MA0061.10.00791773
MA0063.10
MA0066.11.54751
MA0067.10.724802
MA0068.10.302582
MA0069.10.428576
MA0070.10.419162
MA0071.10.144505
MA0072.10.415392
MA0073.11.18869e-06
MA0074.10.165153
MA0076.10.0703269
MA0077.11.05319
MA0078.10.655763
MA0081.12.95994
MA0083.10.447432
MA0084.10.901266
MA0087.10.413345
MA0088.10.120106
MA0089.10
MA0090.10.264964
MA0091.10.355228
MA0092.12.13438
MA0093.10.158872
MA0095.10
MA0098.10
MA0100.10.524766
MA0101.10.162302
MA0103.10.146349
MA0105.10.000911515
MA0106.10.195103
MA0107.10.23285
MA0108.20.828157
MA0109.10
MA0111.10.591831
MA0113.10.594625
MA0114.10.0202192
MA0115.10.654355
MA0116.10.0221565
MA0117.10.473208
MA0119.10.455145
MA0122.10.495633
MA0124.10.616574
MA0125.10.541304
MA0130.10
MA0131.10.245067
MA0132.10
MA0133.10
MA0135.10.466979
MA0136.13.79387
MA0139.10.21732
MA0140.10.142924
MA0141.10.0623757
MA0142.10.778439
MA0143.10.594912
MA0144.10.6423
MA0145.10.0780719
MA0146.10.00212946
MA0147.10.24486
MA0148.11.83841
MA0149.15.91358
MA0062.20.110313
MA0035.20.863515
MA0039.20.000286606
MA0138.20.232954
MA0002.20.0499028
MA0137.20.712564
MA0104.20.0115959
MA0047.21.04713
MA0112.20.0102003
MA0065.20.0824391
MA0150.10.547391
MA0151.10
MA0152.12.04165
MA0153.10.526421
MA0154.10.364484
MA0155.10.117405
MA0156.14.61528
MA0157.10.264816
MA0158.10
MA0159.10.0998181
MA0160.10.130642
MA0161.10
MA0162.14.24945e-06
MA0163.10.00151113
MA0164.10.614845
MA0080.22.46692
MA0018.20.196028
MA0099.21.41986
MA0079.25.42772e-10
MA0102.20.936833
MA0258.10.18561
MA0259.10.025023
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
FOS#2353237.391177575163266.28380072586658e-181.38162918738691e-15
GATA2#2624156.827642000118213.63335374939682e-103.62776130242117e-08
JUN#3725104.468867568691553.6106115242246e-050.000698829979574672



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.