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Coexpression cluster:C4249

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Full id: C4249_Mesenchymal_mesenchymal_Cardiac_Chondrocyte_Myoblast_Preadipocyte_bone



Phase1 CAGE Peaks

  Short description
Hg19::chr2:85980951..85981004,+ p1@ATOH8
Hg19::chr2:85981008..85981025,+ p7@ATOH8
Hg19::chr2:85981027..85981047,+ p8@ATOH8


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data


Uber Anatomy
Ontology termp-valuen
muscle tissue7.18e-1864
musculature7.18e-1864
musculature of body7.18e-1864
skeletal muscle tissue2.15e-1762
striated muscle tissue2.15e-1762
myotome2.15e-1762
splanchnic layer of lateral plate mesoderm1.90e-1583
anatomical cluster5.11e-15373
multi-tissue structure2.58e-14342
anatomical conduit7.48e-14240
vessel9.81e-1468
epithelial vesicle1.95e-1378
dense mesenchyme tissue5.67e-1373
paraxial mesoderm7.38e-1372
presumptive paraxial mesoderm7.38e-1372
somite7.38e-1371
presomitic mesoderm7.38e-1371
presumptive segmental plate7.38e-1371
dermomyotome7.38e-1371
trunk paraxial mesoderm7.38e-1371
epithelial tube open at both ends1.15e-1259
blood vessel1.15e-1259
blood vasculature1.15e-1259
vascular cord1.15e-1259
mesenchyme1.17e-12160
entire embryonic mesenchyme1.17e-12160
trunk mesenchyme1.26e-12122
artery5.08e-1242
arterial blood vessel5.08e-1242
arterial system5.08e-1242
tube2.44e-11192
vasculature2.48e-1178
vascular system2.48e-1178
epithelial tube2.65e-11117
epithelium1.80e-10306
multilaminar epithelium1.96e-1083
circulatory system4.53e-10112
systemic artery5.85e-1033
systemic arterial system5.85e-1033
cell layer6.16e-10309
unilaminar epithelium1.31e-09148
cardiovascular system1.46e-09109
multi-cellular organism3.88e-09656
trunk2.81e-08199
primary circulatory organ3.29e-0827
heart1.04e-0724
primitive heart tube1.04e-0724
primary heart field1.04e-0724
anterior lateral plate mesoderm1.04e-0724
heart tube1.04e-0724
heart primordium1.04e-0724
cardiac mesoderm1.04e-0724
cardiogenic plate1.04e-0724
heart rudiment1.04e-0724
adult organism6.69e-07114


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.13.22681
MA0004.11.93041
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.10.377374
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.904546
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.10.333427
MA0058.12.8588
MA0059.11.70014
MA0060.10.492218
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.11.04561
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.110.4901
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.257905
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.11.55117
MA0095.10
MA0098.10
MA0100.13.60951
MA0101.10.646932
MA0103.10.628063
MA0105.10.31555
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.12.29491
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.13.943
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.12.11725
MA0146.10.107247
MA0147.10.565108
MA0148.11.98824
MA0149.10.884158
MA0062.20.449458
MA0035.20.894194
MA0039.21.15986
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.21.2307
MA0047.20.973066
MA0112.20.264678
MA0065.20.760954
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.10.711948
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.10.455568
MA0163.10.387745
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.25.72079
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
E2F1#186934.907389214879320.008460985347239390.0326421945506385
FOXA1#3169311.08141974938550.000734755275698670.0058253325923247
FOXA2#3170324.63046375266526.68983856509345e-050.00107423131903413
TCF7L2#6934310.77017656313730.0008003181298398380.0061558716425352
USF1#739136.361499277207960.00388404057290560.0190820074039744
USF2#7392312.99219738506960.0004558979393427810.00422405295307139



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.