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MCL coexpression mm9:3247

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Phase1 CAGE Peaks

 Short description
Mm9::chr1:174204455..174204475,-p@chr1:174204455..174204475
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Mm9::chr1:174228120..174228139,-p1@Atp1a2
Mm9::chr2:71205623..71205634,-p2@Slc25a12


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0051481reduction of cytosolic calcium ion concentration0.00849152215471345
GO:0045988negative regulation of striated muscle contraction0.00849152215471345
GO:0043490malate-aspartate shuttle0.00849152215471345
GO:0006942regulation of striated muscle contraction0.00849152215471345
GO:0002087neurological control of breathing0.0101895474352689
GO:0003016respiratory system process0.012735887480134
GO:0045932negative regulation of muscle contraction0.012735887480134
GO:0045822negative regulation of heart contraction0.012735887480134
GO:0001504neurotransmitter uptake0.0132072251548221
GO:0019229regulation of vasoconstriction0.0135842022444435
GO:0005391sodium:potassium-exchanging ATPase activity0.0154357475493305
GO:0002026regulation of the force of heart contraction0.0183927537650214
GO:0042310vasoconstriction0.0206137938818341
GO:0006940regulation of smooth muscle contraction0.0206137938818341
GO:0051480cytosolic calcium ion homeostasis0.0215018377280429
GO:0007632visual behavior0.0219660155602007
GO:0008542visual learning0.0219660155602007
GO:0006939smooth muscle contraction0.0230766925527323
GO:0042383sarcolemma0.0230766925527323
GO:0051241negative regulation of multicellular organismal process0.0230766925527323
GO:0006941striated muscle contraction0.0230766925527323
GO:0006937regulation of muscle contraction0.0230766925527323
GO:0003018vascular process in circulatory system0.0230766925527323
GO:0035150regulation of tube size0.0230766925527323
GO:0050880regulation of blood vessel size0.0230766925527323
GO:0008016regulation of heart contraction0.0234930818595918
GO:0008217regulation of blood pressure0.0248798055474021
GO:0008344adult locomotory behavior0.0248798055474021
GO:0003015heart process0.0248798055474021
GO:0060047heart contraction0.0248798055474021
GO:0006836neurotransmitter transport0.025971803091423
GO:0007612learning0.025971803091423
GO:0006874cellular calcium ion homeostasis0.0287303129389502
GO:0015662ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism0.0287303129389502
GO:0055074calcium ion homeostasis0.0287303129389502
GO:0030534adult behavior0.0287303129389502
GO:0006875cellular metal ion homeostasis0.0295579222601135
GO:0055065metal ion homeostasis0.0295579222601135
GO:0007611learning and/or memory0.0295579222601135
GO:0009416response to light stimulus0.030933771012325
GO:0031402sodium ion binding0.0319651090362122
GO:0042625ATPase activity, coupled to transmembrane movement of ions0.0319651090362122
GO:0003012muscle system process0.0319651090362122
GO:0006936muscle contraction0.0319651090362122
GO:0001505regulation of neurotransmitter levels0.0325234766376159
GO:0009314response to radiation0.0325234766376159
GO:0008015blood circulation0.0325234766376159
GO:0003013circulatory system process0.0325234766376159
GO:0030005cellular di-, tri-valent inorganic cation homeostasis0.0325234766376159
GO:0015077monovalent inorganic cation transmembrane transporter activity0.0325234766376159
GO:0055066di-, tri-valent inorganic cation homeostasis0.0325482600833689
GO:0030003cellular cation homeostasis0.0338600114717001
GO:0055080cation homeostasis0.0338600114717001
GO:0030955potassium ion binding0.0338600114717001
GO:0006814sodium ion transport0.0338600114717001
GO:0043492ATPase activity, coupled to movement of substances0.0338600114717001
GO:0042626ATPase activity, coupled to transmembrane movement of substances0.0338600114717001
GO:0016820hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances0.0338600114717001
GO:0015399primary active transmembrane transporter activity0.036105435153291
GO:0015405P-P-bond-hydrolysis-driven transmembrane transporter activity0.036105435153291
GO:0022890inorganic cation transmembrane transporter activity0.0363428939980021
GO:0006810transport0.0379308700280174
GO:0055082cellular chemical homeostasis0.0379308700280174
GO:0006873cellular ion homeostasis0.0379308700280174
GO:0051234establishment of localization0.0379308700280174
GO:0035239tube morphogenesis0.0379308700280174
GO:0005792microsome0.0380537807894322
GO:0006813potassium ion transport0.0380537807894322
GO:0042598vesicular fraction0.0384784939438254
GO:0050801ion homeostasis0.040002486394148
GO:0009628response to abiotic stimulus0.040002486394148
GO:0031420alkali metal ion binding0.0415498292225967
GO:0051179localization0.0433805360234735
GO:0007268synaptic transmission0.0433805360234735
GO:0035295tube development0.0448918266372321
GO:0007626locomotory behavior0.0448918266372321
GO:0048878chemical homeostasis0.0456173786585225
GO:0019725cellular homeostasis0.0456782725779116
GO:0042623ATPase activity, coupled0.0474730127310945
GO:0019226transmission of nerve impulse0.0474730127310945
GO:0005743mitochondrial inner membrane0.0477152101550416
GO:0019866organelle inner membrane0.0489735652120997



Relative expression of the co-expression cluster over median <br>Analyst:




Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
CNS neuron (sensu Vertebrata)1.79e-0723
neuroblast (sensu Vertebrata)1.79e-0723
neuron4.46e-0733
neuronal stem cell4.46e-0733
neuroblast4.46e-0733
electrically signaling cell4.46e-0733

Uber Anatomy
Ontology termp-valuen
structure with developmental contribution from neural crest3.79e-2092
central nervous system1.31e-1973
nervous system4.31e-1975
ectoderm-derived structure7.43e-1995
ectoderm7.43e-1995
presumptive ectoderm7.43e-1995
regional part of nervous system8.51e-1954
neural tube1.67e-1752
neural rod1.67e-1752
future spinal cord1.67e-1752
neural keel1.67e-1752
ecto-epithelium1.48e-1673
neurectoderm1.31e-1564
neural plate1.31e-1564
presumptive neural plate1.31e-1564
brain1.90e-1547
future brain1.90e-1547
regional part of brain7.31e-1546
gray matter4.67e-1334
anterior neural tube1.56e-1240
regional part of forebrain6.72e-1239
forebrain6.72e-1239
future forebrain6.72e-1239
anatomical conduit1.57e-11122
brain grey matter3.19e-1129
regional part of telencephalon3.19e-1129
telencephalon3.19e-1129
tube5.50e-11114
pre-chordal neural plate9.56e-1149
regional part of cerebral cortex2.18e-0817
cerebral cortex2.90e-0821
cerebral hemisphere2.90e-0821
pallium2.90e-0821
occipital lobe7.53e-0710
visual cortex7.53e-0710
neocortex7.53e-0710


TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs




JASPAR motifs


Motifs-log10(p-value)
MA0003.10.526413
MA0004.10.801718
MA0006.10.60285
MA0007.10.784593
MA0009.11.27673
MA0014.10.133574
MA0017.10.635031
MA0019.11.08369
MA0024.11.23079
MA0025.11.51835
MA0027.12.9431
MA0028.10.61552
MA0029.11.20789
MA0030.11.21482
MA0031.11.17722
MA0038.10.963265
MA0040.11.28983
MA0041.10.714279
MA0042.10.69885
MA0043.11.3775
MA0046.11.31428
MA0048.10.932001
MA0050.10.845669
MA0051.10.973068
MA0052.11.29825
MA0055.11.06076
MA0056.10
MA0057.12.43475
MA0058.10.690848
MA0059.10.705317
MA0060.10.502699
MA0061.10.5406
MA0063.10
MA0066.12.18658
MA0067.11.63197
MA0068.10.908538
MA0069.11.29861
MA0070.11.28847
MA0071.10.844726
MA0072.11.2796
MA0073.10.121346
MA0074.10.911576
MA0076.10.657929
MA0077.11.2569
MA0078.11.0091
MA0081.10.732313
MA0083.11.37668
MA0084.11.96428
MA0087.11.33189
MA0088.11.40099
MA0089.10
MA0090.10.762482
MA0091.10.816659
MA0092.10.762845
MA0093.10.62555
MA0095.10
MA0098.10
MA0100.10.89873
MA0101.10.71579
MA0103.10.647985
MA0105.10.405648
MA0106.11.01755
MA0107.10.640607
MA0108.21.10817
MA0109.10
MA0111.10.778753
MA0113.10.986839
MA0114.10.537669
MA0115.11.38041
MA0116.10.602598
MA0117.11.34691
MA0119.10.716476
MA0122.11.36752
MA0124.11.57762
MA0125.11.5017
MA0130.10
MA0131.11.07881
MA0132.10
MA0133.10
MA0135.11.4152
MA0136.10.933582
MA0139.10.462282
MA0140.10.898603
MA0141.11.61065
MA0142.11.16183
MA0143.11.00467
MA0144.10.541532
MA0145.10.292366
MA0146.10.46063
MA0147.10.556853
MA0148.10.820161
MA0149.10.722227
MA0062.20.412742
MA0035.20.903829
MA0039.20.181475
MA0138.21.07027
MA0002.20.466067
MA0137.20.668025
MA0104.20.48458
MA0047.20.962424
MA0112.20.29236
MA0065.20.292912
MA0150.10.784464
MA0151.10
MA0152.10.962542
MA0153.11.43238
MA0154.10.35067
MA0155.11.52001
MA0156.10.656895
MA0157.11.12772
MA0158.10
MA0159.10.569393
MA0160.11.92525
MA0161.10
MA0162.10.499274
MA0163.10.157796
MA0164.10.933981
MA0080.20.64167
MA0018.20.944669
MA0099.21.06348
MA0079.21.16605
MA0102.22.01714
MA0258.10.520639
MA0259.10.543506
MA0442.10
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