MCL coexpression mm9:342
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0045794 | negative regulation of cell volume | 0.00890264614036049 |
GO:0032344 | regulation of aldosterone metabolic process | 0.00890264614036049 |
GO:0060082 | eye blink reflex | 0.00890264614036049 |
GO:0004058 | aromatic-L-amino-acid decarboxylase activity | 0.00890264614036049 |
GO:0032196 | transposition | 0.00890264614036049 |
GO:0006313 | transposition, DNA-mediated | 0.00890264614036049 |
GO:0019228 | generation of action potential | 0.00890264614036049 |
GO:0060072 | large conductance calcium-activated potassium channel activity | 0.00890264614036049 |
GO:0032341 | aldosterone metabolic process | 0.0129482392672005 |
GO:0060083 | smooth muscle contraction involved in micturition | 0.0129482392672005 |
GO:0008212 | mineralocorticoid metabolic process | 0.0129482392672005 |
GO:0007423 | sensory organ development | 0.0133517743582362 |
GO:0046541 | saliva secretion | 0.0133517743582362 |
GO:0060087 | relaxation of vascular smooth muscle | 0.0133517743582362 |
GO:0045475 | locomotor rhythm | 0.0133517743582362 |
GO:0032350 | regulation of hormone metabolic process | 0.0133517743582362 |
GO:0035295 | tube development | 0.0136405841796192 |
GO:0046668 | regulation of retinal cell programmed cell death | 0.0149902338833339 |
GO:0006884 | regulation of cell volume | 0.0149902338833339 |
GO:0060073 | micturition | 0.0161813088807534 |
GO:0048512 | circadian behavior | 0.0161813088807534 |
GO:0045986 | negative regulation of smooth muscle contraction | 0.0161813088807534 |
GO:0043195 | terminal button | 0.0166100798772788 |
GO:0046666 | retinal cell programmed cell death | 0.0166100798772788 |
GO:0045932 | negative regulation of muscle contraction | 0.0166100798772788 |
GO:0006519 | amino acid and derivative metabolic process | 0.0166100798772788 |
GO:0019218 | regulation of steroid metabolic process | 0.0166100798772788 |
GO:0045766 | positive regulation of angiogenesis | 0.0166100798772788 |
GO:0003964 | RNA-directed DNA polymerase activity | 0.0166100798772788 |
GO:0007622 | rhythmic behavior | 0.0166100798772788 |
GO:0060004 | reflex | 0.0169448824132453 |
GO:0007267 | cell-cell signaling | 0.0169448824132453 |
GO:0009308 | amine metabolic process | 0.0169448824132453 |
GO:0021940 | positive regulation of granule cell precursor proliferation | 0.0169448824132453 |
GO:0019031 | viral envelope | 0.0169448824132453 |
GO:0033267 | axon part | 0.0169448824132453 |
GO:0021936 | regulation of granule cell precursor proliferation | 0.0169448824132453 |
GO:0006807 | nitrogen compound metabolic process | 0.0169448824132453 |
GO:0042423 | catecholamine biosynthetic process | 0.0169448824132453 |
GO:0021930 | granule cell precursor proliferation | 0.0169448824132453 |
GO:0021534 | cell proliferation in hindbrain | 0.0169448824132453 |
GO:0021924 | cell proliferation in the external granule layer | 0.0169448824132453 |
GO:0000186 | activation of MAPKK activity | 0.0173953161140378 |
GO:0015269 | calcium-activated potassium channel activity | 0.0173953161140378 |
GO:0007589 | fluid secretion | 0.0173953161140378 |
GO:0010092 | specification of organ identity | 0.0181096647399395 |
GO:0022600 | digestive system process | 0.0181096647399395 |
GO:0022839 | ion gated channel activity | 0.0181096647399395 |
GO:0001759 | induction of an organ | 0.0181096647399395 |
GO:0031128 | induction | 0.0181096647399395 |
GO:0042311 | vasodilation | 0.0181096647399395 |
GO:0044423 | virion part | 0.0181096647399395 |
GO:0045168 | cell-cell signaling during cell fate commitment | 0.0181096647399395 |
GO:0005227 | calcium activated cation channel activity | 0.0181096647399395 |
GO:0003014 | renal system process | 0.0181096647399395 |
GO:0050679 | positive regulation of epithelial cell proliferation | 0.0190551599685365 |
GO:0019752 | carboxylic acid metabolic process | 0.0195566751615055 |
GO:0006082 | organic acid metabolic process | 0.0195566751615055 |
GO:0006940 | regulation of smooth muscle contraction | 0.0204943845685066 |
GO:0004190 | aspartic-type endopeptidase activity | 0.021336517097799 |
GO:0019216 | regulation of lipid metabolic process | 0.0217935754465432 |
GO:0005104 | fibroblast growth factor receptor binding | 0.0217935754465432 |
GO:0051260 | protein homooligomerization | 0.0233310614519163 |
GO:0001666 | response to hypoxia | 0.0233310614519163 |
GO:0007628 | adult walking behavior | 0.0240640544446906 |
GO:0042491 | auditory receptor cell differentiation | 0.0247746585682556 |
GO:0042401 | biogenic amine biosynthetic process | 0.0250894075588815 |
GO:0050678 | regulation of epithelial cell proliferation | 0.0250894075588815 |
GO:0016831 | carboxy-lyase activity | 0.025930627077134 |
GO:0006939 | smooth muscle contraction | 0.025930627077134 |
GO:0001934 | positive regulation of protein amino acid phosphorylation | 0.025930627077134 |
GO:0033240 | positive regulation of amine metabolic process | 0.025930627077134 |
GO:0045764 | positive regulation of amino acid metabolic process | 0.025930627077134 |
GO:0060113 | inner ear receptor cell differentiation | 0.025930627077134 |
GO:0042398 | amino acid derivative biosynthetic process | 0.0259944882515241 |
GO:0051241 | negative regulation of multicellular organismal process | 0.0259944882515241 |
GO:0018958 | phenol metabolic process | 0.0259944882515241 |
GO:0007623 | circadian rhythm | 0.0259944882515241 |
GO:0006584 | catecholamine metabolic process | 0.0259944882515241 |
GO:0051259 | protein oligomerization | 0.0259944882515241 |
GO:0045765 | regulation of angiogenesis | 0.0259944882515241 |
GO:0032147 | activation of protein kinase activity | 0.0259944882515241 |
GO:0050673 | epithelial cell proliferation | 0.0265351635456519 |
GO:0050885 | neuromuscular process controlling balance | 0.027062826715482 |
GO:0006937 | regulation of muscle contraction | 0.0271343841043562 |
GO:0042490 | mechanoreceptor differentiation | 0.0271343841043562 |
GO:0035150 | regulation of tube size | 0.0271343841043562 |
GO:0050880 | regulation of blood vessel size | 0.0271343841043562 |
GO:0003018 | vascular process in circulatory system | 0.0271343841043562 |
GO:0010001 | glial cell differentiation | 0.0296503924151127 |
GO:0016830 | carbon-carbon lyase activity | 0.0296503924151127 |
GO:0007586 | digestion | 0.0308666142778457 |
GO:0042063 | gliogenesis | 0.0310544238753382 |
GO:0008344 | adult locomotory behavior | 0.0310544238753382 |
GO:0030902 | hindbrain development | 0.0310544238753382 |
GO:0042391 | regulation of membrane potential | 0.0310544238753382 |
GO:0048592 | eye morphogenesis | 0.0314634567007677 |
GO:0030170 | pyridoxal phosphate binding | 0.0329704769089509 |
GO:0045597 | positive regulation of cell differentiation | 0.0329704769089509 |
GO:0050905 | neuromuscular process | 0.0333476121965123 |
GO:0016324 | apical plasma membrane | 0.0344167751500116 |
GO:0033238 | regulation of amine metabolic process | 0.0354616015674823 |
GO:0001932 | regulation of protein amino acid phosphorylation | 0.0354616015674823 |
GO:0006521 | regulation of amino acid metabolic process | 0.0354616015674823 |
GO:0008076 | voltage-gated potassium channel complex | 0.0364687924247634 |
GO:0042325 | regulation of phosphorylation | 0.0367629008567103 |
GO:0051174 | regulation of phosphorus metabolic process | 0.0367629008567103 |
GO:0019220 | regulation of phosphate metabolic process | 0.0367629008567103 |
GO:0044238 | primary metabolic process | 0.0375257099524355 |
GO:0009309 | amine biosynthetic process | 0.0375257099524355 |
GO:0008201 | heparin binding | 0.0375257099524355 |
GO:0048519 | negative regulation of biological process | 0.0375257099524355 |
GO:0044237 | cellular metabolic process | 0.0375257099524355 |
GO:0030534 | adult behavior | 0.0379220605897542 |
GO:0030424 | axon | 0.0382054290145383 |
GO:0030324 | lung development | 0.0390914509679259 |
GO:0030323 | respiratory tube development | 0.0393596825726832 |
GO:0044463 | cell projection part | 0.040817260730519 |
GO:0051094 | positive regulation of developmental process | 0.0409692666526285 |
GO:0050878 | regulation of body fluid levels | 0.0409692666526285 |
GO:0048839 | inner ear development | 0.0409692666526285 |
GO:0006576 | biogenic amine metabolic process | 0.0417875351795504 |
GO:0006310 | DNA recombination | 0.0419106468578885 |
GO:0005539 | glycosaminoglycan binding | 0.0419106468578885 |
GO:0048469 | cell maturation | 0.0419106468578885 |
GO:0043583 | ear development | 0.0423585509541974 |
GO:0044271 | nitrogen compound biosynthetic process | 0.0423585509541974 |
GO:0045177 | apical part of cell | 0.0425771180631387 |
GO:0042445 | hormone metabolic process | 0.0438181956187094 |
GO:0030247 | polysaccharide binding | 0.0438181956187094 |
GO:0045860 | positive regulation of protein kinase activity | 0.0438181956187094 |
GO:0003012 | muscle system process | 0.0438181956187094 |
GO:0006936 | muscle contraction | 0.0438181956187094 |
GO:0005249 | voltage-gated potassium channel activity | 0.0438181956187094 |
GO:0001871 | pattern binding | 0.0442068707507138 |
GO:0004519 | endonuclease activity | 0.0442068707507138 |
GO:0006575 | amino acid derivative metabolic process | 0.0449093739861729 |
GO:0033674 | positive regulation of kinase activity | 0.0450926938268783 |
GO:0051347 | positive regulation of transferase activity | 0.0452732925550205 |
GO:0021700 | developmental maturation | 0.045952462281696 |
GO:0007605 | sensory perception of sound | 0.046124155030082 |
GO:0048468 | cell development | 0.0463028947904052 |
GO:0009653 | anatomical structure morphogenesis | 0.0463028947904052 |
GO:0008015 | blood circulation | 0.0463028947904052 |
GO:0003013 | circulatory system process | 0.0463028947904052 |
GO:0050954 | sensory perception of mechanical stimulus | 0.0469461488761132 |
GO:0045165 | cell fate commitment | 0.0480569921767356 |
GO:0001654 | eye development | 0.0496252425198387 |
GO:0019842 | vitamin binding | 0.0497620568061787 |
GO:0016779 | nucleotidyltransferase activity | 0.049896969746898 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
Ontology term | p-value | n |
---|---|---|
bone marrow cell | 6.64e-38 | 3 |
mesenchymal stem cell of the bone marrow | 6.64e-38 | 3 |
central nervous system macrophage | 3.19e-25 | 2 |
microglial cell | 3.19e-25 | 2 |
cardiocyte | 5.00e-18 | 3 |
striated muscle cell | 5.00e-18 | 3 |
cardiac muscle cell | 5.00e-18 | 3 |
cardiac muscle myoblast | 5.00e-18 | 3 |
monopoietic cell | 3.67e-13 | 4 |
myeloid leukocyte | 3.67e-13 | 4 |
phagocyte | 3.67e-13 | 4 |
monocyte | 3.67e-13 | 4 |
macrophage | 3.67e-13 | 4 |
tissue-resident macrophage | 3.67e-13 | 4 |
macrophage dendritic cell progenitor | 3.67e-13 | 4 |
monoblast | 3.67e-13 | 4 |
promonocyte | 3.67e-13 | 4 |
muscle precursor cell | 1.61e-09 | 6 |
contractile cell | 1.61e-09 | 6 |
muscle cell | 1.61e-09 | 6 |
myoblast | 1.61e-09 | 6 |
stuff accumulating cell | 4.19e-09 | 6 |
mesodermal cell | 2.72e-08 | 7 |
defensive cell | 6.16e-08 | 7 |
granulocyte monocyte progenitor cell | 6.16e-08 | 7 |
oligodendrocyte precursor cell | 4.66e-07 | 8 |
connective tissue cell | 5.09e-07 | 46 |
mesenchymal cell | 5.09e-07 | 46 |
somatic stem cell | 7.08e-07 | 91 |
multi fate stem cell | 7.08e-07 | 91 |
Ontology term | p-value | n |
---|---|---|
bone marrow | 1.31e-19 | 16 |
musculoskeletal system | 2.74e-19 | 32 |
bone element | 2.25e-14 | 22 |
skeletal element | 2.25e-14 | 22 |
skeletal system | 2.25e-14 | 22 |
lateral plate mesoderm | 3.43e-07 | 87 |
hematopoietic system | 3.59e-07 | 45 |
blood island | 3.59e-07 | 45 |
connective tissue | 5.09e-07 | 46 |
hemolymphoid system | 9.79e-07 | 48 |
immune system | 9.79e-07 | 48 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
MA0003.1 | 0.0379965 |
MA0004.1 | 0.135415 |
MA0006.1 | 0.0509523 |
MA0007.1 | 0.126548 |
MA0009.1 | 0.467692 |
MA0014.1 | 1.63329e-05 |
MA0017.1 | 0.222109 |
MA0019.1 | 5.21568 |
MA0024.1 | 0.430047 |
MA0025.1 | 0.677312 |
MA0027.1 | 2.06014 |
MA0028.1 | 0.055063 |
MA0029.1 | 0.411611 |
MA0030.1 | 0.417163 |
MA0031.1 | 0.387282 |
MA0038.1 | 0.231663 |
MA0040.1 | 0.478574 |
MA0041.1 | 0.0931678 |
MA0042.1 | 0.0865208 |
MA0043.1 | 0.552986 |
MA0046.1 | 0.499059 |
MA0048.1 | 0.0277501 |
MA0050.1 | 0.481243 |
MA0051.1 | 0.238165 |
MA0052.1 | 0.485607 |
MA0055.1 | 0.168072 |
MA0056.1 | 0 |
MA0057.1 | 0.0707752 |
MA0058.1 | 0.0831725 |
MA0059.1 | 0.0892761 |
MA0060.1 | 0.483231 |
MA0061.1 | 0.31638 |
MA0063.1 | 0 |
MA0066.1 | 0.223752 |
MA0067.1 | 0.78096 |
MA0068.1 | 0.00423247 |
MA0069.1 | 0.485904 |
MA0070.1 | 0.477443 |
MA0071.1 | 0.479923 |
MA0072.1 | 0.470071 |
MA0073.1 | 0.00822401 |
MA0074.1 | 1.71791 |
MA0076.1 | 0.0701228 |
MA0077.1 | 0.451332 |
MA0078.1 | 0.726633 |
MA0081.1 | 0.101252 |
MA0083.1 | 0.552276 |
MA0084.1 | 1.09535 |
MA0087.1 | 0.513946 |
MA0088.1 | 0.171701 |
MA0089.1 | 0 |
MA0090.1 | 0.115519 |
MA0091.1 | 0.143375 |
MA0092.1 | 0.115696 |
MA0093.1 | 0.212413 |
MA0095.1 | 0 |
MA0098.1 | 0 |
MA0100.1 | 2.37452 |
MA0101.1 | 1.07479 |
MA0103.1 | 0.235667 |
MA0105.1 | 0.27408 |
MA0106.1 | 1.35881 |
MA0107.1 | 0.493454 |
MA0108.2 | 0.334189 |
MA0109.1 | 0 |
MA0111.1 | 1.27377 |
MA0113.1 | 0.247414 |
MA0114.1 | 0.899025 |
MA0115.1 | 0.555491 |
MA0116.1 | 0.0508724 |
MA0117.1 | 0.526724 |
MA0119.1 | 0.0941347 |
MA0122.1 | 0.544387 |
MA0124.1 | 0.731064 |
MA0125.1 | 1.59167 |
MA0130.1 | 0 |
MA0131.1 | 0.312378 |
MA0132.1 | 0 |
MA0133.1 | 0 |
MA0135.1 | 0.585739 |
MA0136.1 | 0.2124 |
MA0139.1 | 0.078666 |
MA0140.1 | 0.190563 |
MA0141.1 | 0.0753473 |
MA0142.1 | 0.375247 |
MA0143.1 | 0.259584 |
MA0144.1 | 0.912796 |
MA0145.1 | 0.0410716 |
MA0146.1 | 0.0429011 |
MA0147.1 | 0.0375422 |
MA0148.1 | 0.145271 |
MA0149.1 | 0.0966891 |
MA0062.2 | 0.0515767 |
MA0035.2 | 1.07381 |
MA0039.2 | 0.00990489 |
MA0138.2 | 0.306125 |
MA0002.2 | 0.655962 |
MA0137.2 | 0.257328 |
MA0104.2 | 0.0212101 |
MA0047.2 | 0.231108 |
MA0112.2 | 0.0996805 |
MA0065.2 | 0.333255 |
MA0150.1 | 0.794087 |
MA0151.1 | 0 |
MA0152.1 | 1.21903 |
MA0153.1 | 0.600798 |
MA0154.1 | 0.520245 |
MA0155.1 | 0.016317 |
MA0156.1 | 0.0697319 |
MA0157.1 | 0.348973 |
MA0158.1 | 0 |
MA0159.1 | 0.0409628 |
MA0160.1 | 0.147126 |
MA0161.1 | 0 |
MA0162.1 | 0.0110162 |
MA0163.1 | 1.3446 |
MA0164.1 | 0.212655 |
MA0080.2 | 0.229013 |
MA0018.2 | 0.219518 |
MA0099.2 | 0.301184 |
MA0079.2 | 6.42975e-11 |
MA0102.2 | 1.14642 |
MA0258.1 | 0.284909 |
MA0259.1 | 0.0340942 |
MA0442.1 | 0 |