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Coexpression cluster:C4594

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Full id: C4594_CD14_immature_CD19_Basophils_Dendritic_migratory_Eosinophils



Phase1 CAGE Peaks

Hg19::chr6:32636121..32636132,-p11@HLA-DQB1
Hg19::chr6:32636145..32636158,-p8@HLA-DQB1
Hg19::chr6:32636163..32636177,-p4@HLA-DQB1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
leukocyte2.74e-66140
nongranular leukocyte1.76e-53119
hematopoietic lineage restricted progenitor cell2.05e-52124
hematopoietic stem cell4.49e-50172
angioblastic mesenchymal cell4.49e-50172
hematopoietic cell3.55e-46182
hematopoietic oligopotent progenitor cell6.78e-46165
hematopoietic multipotent progenitor cell6.78e-46165
CD14-positive, CD16-negative classical monocyte2.72e-3442
classical monocyte2.21e-3145
macrophage dendritic cell progenitor2.01e-3065
myeloid leukocyte1.32e-2976
granulocyte monocyte progenitor cell1.09e-2871
monopoietic cell1.20e-2763
monocyte1.20e-2763
monoblast1.20e-2763
promonocyte1.20e-2763
myeloid lineage restricted progenitor cell1.58e-2570
myeloid cell6.94e-23112
common myeloid progenitor6.94e-23112
lymphoid lineage restricted progenitor cell1.41e-2252
lymphocyte5.44e-2253
common lymphoid progenitor5.44e-2253
dendritic cell1.23e-2010
B cell5.62e-1714
conventional dendritic cell7.16e-178
mesenchymal cell1.92e-15358
connective tissue cell9.25e-15365
lymphocyte of B lineage9.86e-1424
pro-B cell9.86e-1424
motile cell2.27e-12390
immature conventional dendritic cell2.71e-115
common dendritic progenitor2.71e-115
Langerhans cell7.21e-115
stem cell8.50e-11444
multi fate stem cell4.68e-10430
CD8-positive, alpha-beta T cell5.14e-1011
somatic stem cell1.19e-09436
mature alpha-beta T cell7.54e-0918
alpha-beta T cell7.54e-0918
immature T cell7.54e-0918
mature T cell7.54e-0918
immature alpha-beta T cell7.54e-0918
T cell1.88e-0825
pro-T cell1.88e-0825
intermediate monocyte2.64e-089
CD14-positive, CD16-positive monocyte2.64e-089
plasmacytoid dendritic cell1.82e-073
Uber Anatomy
Ontology termp-valuen
hematopoietic system1.08e-28102
blood island1.08e-28102
hemolymphoid system3.03e-26112
bone marrow1.01e-2580
bone element3.73e-2386
skeletal element4.22e-18101
skeletal system4.22e-18101
immune system1.50e-17115
connective tissue7.85e-14375
lateral plate mesoderm9.35e-09216
musculoskeletal system1.33e-07167


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.