MCL coexpression mm9:822

Phase1 CAGE Peaks

	Short description
Mm9::chr14:70205025..70205099,-	p4@Rhobtb2
Mm9::chr15:63891780..63891840,-	p4@Fam49b
Mm9::chr19:46119482..46119617,-	p1@Ldb1
Mm9::chr1:181476539..181476564,+	p2@Cnst
Mm9::chr6:142912628..142912648,-	p5@St8sia1
Mm9::chr6:142912655..142912712,-	p1@St8sia1
Mm9::chr6:142912888..142912923,-	p2@St8sia1
Mm9::chr6:142912924..142912958,-	p4@St8sia1
Mm9::chr7:25689435..25689478,+	p2@Arhgef1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0030274	LIM domain binding	0.031311569005268
GO:0045647	negative regulation of erythrocyte differentiation	0.031311569005268
GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity	0.031311569005268
GO:0021692	cerebellar Purkinje cell layer morphogenesis	0.031311569005268
GO:0045646	regulation of erythrocyte differentiation	0.031311569005268
GO:0021694	cerebellar Purkinje cell layer formation	0.031311569005268
GO:0021702	cerebellar Purkinje cell differentiation	0.031311569005268
GO:0007264	small GTPase mediated signal transduction	0.031311569005268
GO:0009948	anterior/posterior axis specification	0.031311569005268
GO:0021697	cerebellar cortex formation	0.031311569005268
GO:0021533	cell differentiation in hindbrain	0.031311569005268
GO:0021680	cerebellar Purkinje cell layer development	0.0329351728611453
GO:0021696	cerebellar cortex morphogenesis	0.0329351728611453
GO:0021587	cerebellum morphogenesis	0.0329351728611453
GO:0021575	hindbrain morphogenesis	0.0329351728611453
GO:0009798	axis specification	0.0329351728611453
GO:0021695	cerebellar cortex development	0.0329351728611453
GO:0045638	negative regulation of myeloid cell differentiation	0.0329351728611453
GO:0008373	sialyltransferase activity	0.0329351728611453
GO:0022037	metencephalon development	0.0339951706826381
GO:0021549	cerebellum development	0.0339951706826381
GO:0030173	integral to Golgi membrane	0.0339951706826381
GO:0031228	intrinsic to Golgi membrane	0.0339951706826381
GO:0001702	gastrulation with mouth forming second	0.040377673861967
GO:0045637	regulation of myeloid cell differentiation	0.0437497994423553
GO:0030218	erythrocyte differentiation	0.0444636384954912
GO:0030902	hindbrain development	0.0485829209071958

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
CNS neuron (sensu Vertebrata)	3.25e-10	23
neuroblast (sensu Vertebrata)	3.25e-10	23
neuron	1.80e-07	33
neuronal stem cell	1.80e-07	33
neuroblast	1.80e-07	33
electrically signaling cell	1.80e-07	33

Uber Anatomy

Ontology term	p-value	n
neurectoderm	9.51e-20	64
neural plate	9.51e-20	64
presumptive neural plate	9.51e-20	64
regional part of nervous system	1.22e-19	54
neural tube	1.56e-18	52
neural rod	1.56e-18	52
future spinal cord	1.56e-18	52
neural keel	1.56e-18	52
central nervous system	7.29e-17	73
ecto-epithelium	1.16e-16	73
brain	1.96e-16	47
future brain	1.96e-16	47
regional part of brain	6.55e-16	46
pre-chordal neural plate	8.55e-16	49
nervous system	2.13e-15	75
anterior neural tube	4.22e-14	40
ectoderm-derived structure	5.00e-14	95
ectoderm	5.00e-14	95
presumptive ectoderm	5.00e-14	95
gray matter	6.74e-14	34
regional part of forebrain	1.75e-13	39
forebrain	1.75e-13	39
future forebrain	1.75e-13	39
structure with developmental contribution from neural crest	1.03e-12	92
brain grey matter	5.61e-12	29
regional part of telencephalon	5.61e-12	29
telencephalon	5.61e-12	29
craniocervical region	4.18e-09	36
gland of gut	2.56e-08	24
thymus	3.19e-08	23
neck	3.19e-08	23
respiratory system epithelium	3.19e-08	23
hemolymphoid system gland	3.19e-08	23
pharyngeal epithelium	3.19e-08	23
thymic region	3.19e-08	23
pharyngeal gland	3.19e-08	23
entire pharyngeal arch endoderm	3.19e-08	23
thymus primordium	3.19e-08	23
early pharyngeal endoderm	3.19e-08	23
cerebral cortex	3.95e-08	21
cerebral hemisphere	3.95e-08	21
pallium	3.95e-08	21
hemopoietic organ	1.45e-07	29
immune organ	1.45e-07	29
anterior region of body	1.61e-07	43
pharynx	2.82e-07	24
upper respiratory tract	2.82e-07	24
chordate pharynx	2.82e-07	24
pharyngeal arch system	2.82e-07	24
pharyngeal region of foregut	2.82e-07	24
regional part of cerebral cortex	9.32e-07	17

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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