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{{Coexpression_clusters
{
|full_id=C3670_CD14_Mesenchymal_Eosinophils_CD14CD16_Monocytederived_Neutrophils_Macrophage

Latest revision as of 12:30, 17 September 2013


Full id: C3670_CD14_Mesenchymal_Eosinophils_CD14CD16_Monocytederived_Neutrophils_Macrophage



Phase1 CAGE Peaks

Hg19::chr17:6915808..6915823,+p5@RNASEK
p8@C17orf49
Hg19::chr8:146078860..146078917,-p3@COMMD5
Hg19::chr8:146078927..146078951,-p4@COMMD5


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
myeloid leukocyte3.61e-3772
macrophage dendritic cell progenitor3.85e-3361
monopoietic cell5.05e-3259
monocyte5.05e-3259
monoblast5.05e-3259
promonocyte5.05e-3259
granulocyte monocyte progenitor cell7.37e-3267
defensive cell9.87e-3148
phagocyte9.87e-3148
myeloid lineage restricted progenitor cell7.97e-3066
classical monocyte2.52e-2742
CD14-positive, CD16-negative classical monocyte2.52e-2742
stuff accumulating cell2.41e-2287
myeloid cell1.14e-21108
common myeloid progenitor1.14e-21108
multi fate stem cell4.84e-11427
leukocyte1.56e-10136
somatic stem cell2.53e-10433
stem cell2.74e-09441
endothelial cell3.07e-0936
connective tissue cell4.94e-09361
mesenchymal cell5.85e-09354
hematopoietic lineage restricted progenitor cell2.68e-07120
lining cell3.19e-0758
barrier cell3.19e-0758
nongranular leukocyte5.73e-07115
Uber Anatomy
Ontology termp-valuen
lateral plate mesoderm4.45e-31203
hemolymphoid system3.71e-29108
bone marrow9.06e-2976
mesoderm1.14e-28315
mesoderm-derived structure1.14e-28315
presumptive mesoderm1.14e-28315
immune system4.29e-2893
hematopoietic system1.39e-2698
blood island1.39e-2698
bone element1.53e-2482
skeletal element2.23e-2390
skeletal system2.01e-21100
musculoskeletal system1.13e-20167
embryonic structure1.66e-08564
connective tissue1.81e-08371
germ layer3.39e-08560
germ layer / neural crest3.39e-08560
embryonic tissue3.39e-08560
presumptive structure3.39e-08560
germ layer / neural crest derived structure3.39e-08560
epiblast (generic)3.39e-08560
circulatory system4.84e-08112
cardiovascular system4.90e-08109
vessel5.56e-0768


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.178364
MA0004.11.93041
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.10.758317
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.11.58389
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.11.90116
MA0051.12.15619
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.10.886807
MA0058.11.70328
MA0059.10.714521
MA0060.10.492218
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.0185922
MA0074.10.935474
MA0076.10.734647
MA0077.12.86846
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.257905
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.12.626
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.31555
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.10.273764
MA0146.10.107247
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.20.449458
MA0035.20.894194
MA0039.20.195278
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.20.491226
MA0047.20.973066
MA0112.20.264678
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.10.256269
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.10.8915
MA0163.10.387745
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.20.311277
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
E2F6#187635.017155731697390.00791769806886330.0321794944395849
ELF1#199734.258097958807540.01295179875054610.0461773430412823
MYC#460935.22228187160940.007020843755740150.0294217920313677
SMARCB1#6598212.16847718743830.008675002221921740.0329841472642815
USF1#739136.361499277207960.00388404057290560.0190104655259953
USF2#7392312.99219738506960.0004558979393427810.00421321342244233
YY1#752834.911170749853860.008441455341808260.0328998452977241
ZBTB33#10009221.10981668665410.002928597060603240.0156346035072505



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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