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Coexpression cluster:C4590: Difference between revisions

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{{Coexpression_clusters
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465,0.469078,0.598234,0.777097,0.718382,0.63803,0.901413,0.726632,0.939121,0.808003,0.69206,0.645308,1.02504,0.951993,0.336258,1.29475,1.45259,0.928548,0.650353,0.892517,1.0078,0.891404,1.25741,0.941709,0.492369,1.14672,0.961293,1.11026,1.54311,1.91674,1.2037,1.75271,3.00424,1.25415,0.333216,1.45054,2.87582,1.06461,1.02656,1.12884,1.20029,0.73687,0.459024,1.14559,0.960908,1.24629,1.39759,1.55552,0.303648,3.62511,1.053,2.0169,1.63834,1.36973,1.23218,0.543775,0.642354,0.560075,1.99742,1.27663,1.05794,0.360456,0.569121,1.22626,1.27082,1.1798,1.09802,0.815119,1.16312,0.921547,1.7605,0.622396,0.703975,1.26794,1.63757,0.830777,1.58942,0.594137,0.188952,0.794219,1.10778,0.547323,1.44203,1.0504,0.850918,0.973172,1.70203,1.12965,0.930979,1.2374,1.48578,4.66191,1.37044,0.798812,1.50051,0.969553,1.65144,0.372828,0.788803,0.843556,1.60823,2.47382,2.06967,1.57016,0.932872,1.27296,1.09989,0.883164,1.08214,2.31409,0.773313,0.539692,0.318511,0.698641,1.37083,4.21132,0.941179,1.78371,1.03563,0.624795,0.744018,0.710709,1.56892,1.35169,1.19946,0.714443,1.11698,0.960047,0.524529,2.15653,0.265282|tfbs_overrepresentation_jaspar=MA0003.1;0.708947,MA0004.1;0.826076,MA0006.1;0.639288,MA0007.1;0.804807,MA0009.1;1.3275,MA0014.1;3.14798,MA0017.1;1.64148,MA0019.1;0.990656,MA0024.1;1.21731,MA0025.1;1.46617,MA0027.1;2.95767,MA0028.1;0.658629,MA0029.1;1.23771,MA0030.1;1.22561,MA0031.1;1.15713,MA0038.1;0.94098,MA0040.1;1.24388,MA0041.1;0.847069,MA0042.1;0.810843,MA0043.1;1.32783,MA0046.1;1.31611,MA0048.1;0.904546,MA0050.1;0.81185,MA0051.1;0.936307,MA0052.1;1.24796,MA0055.1;2.37507,MA0056.1;0,MA0057.1;0.333427,MA0058.1;0.716037,MA0059.1;0.714521,MA0060.1;0.492218,MA0061.1;0.456531,MA0063.1;0,MA0066.1;0.941452,MA0067.1;1.65513,MA0068.1;0.405474,MA0069.1;1.31207,MA0070.1;1.30033,MA0071.1;0.897953,MA0072.1;1.29561,MA0073.1;4.54482,MA0074.1;0.935474,MA0076.1;0.734647,MA0077.1;1.28751,MA0078.1;1.04495,MA0081.1;0.714712,MA0083.1;1.33535,MA0084.1;1.84562,MA0087.1;1.29304,MA0088.1;0.715722,MA0089.1;0,MA0090.1;0.751469,MA0091.1;0.829044,MA0092.1;0.785956,MA0093.1;0.642957,MA0095.1;0,MA0098.1;0,MA0100.1;0.956299,MA0101.1;0.646932,MA0103.1;0.628063,MA0105.1;0.31555,MA0106.1;0.986396,MA0107.1;0.556367,MA0108.2;1.15387,MA0109.1;0,MA0111.1;0.767139,MA0113.1;1.00436,MA0114.1;0.549955,MA0115.1;1.57693,MA0116.1;4.65896,MA0117.1;1.36676,MA0119.1;0.695578,MA0122.1;1.39371,MA0124.1;1.53432,MA0125.1;1.44766,MA0130.1;0,MA0131.1;1.06461,MA0132.1;0,MA0133.1;0,MA0135.1;1.35921,MA0136.1;0.948776,MA0139.1;0.440097,MA0140.1;0.894983,MA0141.1;0.712476,MA0142.1;1.12317,MA0143.1;1.00455,MA0144.1;0.531867,MA0145.1;0.752137,MA0146.1;0.107247,MA0147.1;0.565108,MA0148.1;0.854239,MA0149.1;0.884158,MA0062.2;0.449458,MA0035.2;0.894194,MA0039.2;2.74132,MA0138.2;1.04628,MA0002.2;0.476938,MA0137.2;2.70092,MA0104.2;0.491226,MA0047.2;0.973066,MA0112.2;0.731309,MA0065.2;3.88385,MA0150.1;0.744617,MA0151.1;0,MA0152.1;0.902317,MA0153.1;1.43021,MA0154.1;0.312019,MA0155.1;0.256269,MA0156.1;0.669101,MA0157.1;1.09377,MA0158.1;0,MA0159.1;0.565904,MA0160.1;0.871361,MA0161.1;0,MA0162.1;0.455568,MA0163.1;1.84145,MA0164.1;1.01792,MA0080.2;0.643061,MA0018.2;0.987913,MA0099.2;0.902716,MA0079.2;4.10519,MA0102.2;1.88331,MA0258.1;0.519674,MA0259.1;0.575594,MA0442.1;0}}
|full_id=C4590_Neutrophils_Eosinophils_Whole_embryonic_osteosarcoma_Fibroblast_CD14
|id=C4590
}}

Latest revision as of 14:15, 17 September 2013


Full id: C4590_Neutrophils_Eosinophils_Whole_embryonic_osteosarcoma_Fibroblast_CD14



Phase1 CAGE Peaks

Hg19::chr6:30654342..30654353,-p11@PPP1R18
Hg19::chr6:30654376..30654395,-p5@PPP1R18
Hg19::chr6:30654401..30654477,-p1@PPP1R18


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
somatic cell2.25e-24588
mesodermal cell5.72e-16121
classical monocyte5.08e-1542
CD14-positive, CD16-negative classical monocyte5.08e-1542
defensive cell1.68e-1348
phagocyte1.68e-1348
myeloid leukocyte3.82e-1372
animal cell6.94e-13679
eukaryotic cell6.94e-13679
endothelial cell7.48e-1336
somatic stem cell7.20e-12433
native cell1.23e-11722
multi fate stem cell1.53e-11427
endothelial cell of vascular tree5.67e-1124
meso-epithelial cell6.69e-1145
stem cell1.82e-10441
monopoietic cell1.99e-1059
monocyte1.99e-1059
monoblast1.99e-1059
promonocyte1.99e-1059
vascular associated smooth muscle cell2.67e-1032
macrophage dendritic cell progenitor2.82e-1061
smooth muscle cell9.24e-1043
smooth muscle myoblast9.24e-1043
granulocyte monocyte progenitor cell1.41e-0967
lining cell3.02e-0958
barrier cell3.02e-0958
blood vessel endothelial cell3.08e-0918
embryonic blood vessel endothelial progenitor cell3.08e-0918
myeloid lineage restricted progenitor cell1.25e-0866
stuff accumulating cell6.27e-0887
contractile cell1.26e-0759
muscle precursor cell1.97e-0758
myoblast1.97e-0758
multi-potent skeletal muscle stem cell1.97e-0758
embryonic cell2.13e-07250
muscle cell4.71e-0755
Uber Anatomy
Ontology termp-valuen
lateral plate mesoderm2.55e-28203
vessel1.36e-2268
mesoderm4.50e-22315
mesoderm-derived structure4.50e-22315
presumptive mesoderm4.50e-22315
cardiovascular system9.33e-22109
vasculature3.07e-2178
vascular system3.07e-2178
circulatory system2.08e-20112
epithelial tube open at both ends4.29e-2059
blood vessel4.29e-2059
blood vasculature4.29e-2059
vascular cord4.29e-2059
splanchnic layer of lateral plate mesoderm6.44e-1783
artery1.36e-1642
arterial blood vessel1.36e-1642
arterial system1.36e-1642
musculoskeletal system2.20e-14167
systemic artery5.47e-1333
systemic arterial system5.47e-1333
hemolymphoid system6.30e-13108
immune system1.02e-1093
hematopoietic system3.40e-1098
blood island3.40e-1098
epithelial tube6.51e-10117
blood vessel endothelium3.08e-0918
endothelium3.08e-0918
cardiovascular system endothelium3.08e-0918
bone marrow7.76e-0976
aorta7.93e-0921
aortic system7.93e-0921
skeletal system1.10e-08100
skeletal element1.24e-0890
bone element3.51e-0882
multilaminar epithelium4.01e-0883
epithelial vesicle6.61e-0878
simple squamous epithelium1.30e-0722
squamous epithelium4.72e-0725
somite7.20e-0771
presomitic mesoderm7.20e-0771
presumptive segmental plate7.20e-0771
dermomyotome7.20e-0771
trunk paraxial mesoderm7.20e-0771


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.708947
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.13.14798
MA0017.11.64148
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.904546
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.12.37507
MA0056.10
MA0057.10.333427
MA0058.10.716037
MA0059.10.714521
MA0060.10.492218
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.14.54482
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.715722
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.31555
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.14.65896
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.10.752137
MA0146.10.107247
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.20.449458
MA0035.20.894194
MA0039.22.74132
MA0138.21.04628
MA0002.20.476938
MA0137.22.70092
MA0104.20.491226
MA0047.20.973066
MA0112.20.731309
MA0065.23.88385
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.10.256269
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.10.455568
MA0163.11.84145
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.24.10519
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CCNT2#90536.336201576962630.003930750035764890.0190985625952663
CTBP2#1488362.71700033932814.049570681927e-060.00013045438385249
EBF1#187938.9064668465690.00141523283560980.00918731365727576
EGR1#195834.988179094810140.008056488137383440.0322231757268761
ETS1#211339.728760922202340.001085840092584840.00764899861253661
SIN3A#2594235.408884726815140.006318961977991520.0278094505085945
SMARCB1#6598318.25271578115740.000164397760679890.00203889534825401
ZBTB7A#5134137.35190930787590.002516255860282270.0140825918113724
ZNF263#1012738.221841637010680.001799043925565870.0110038271474187



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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