Coexpression cluster:C2219

Full id: C2219_Smooth_Mesenchymal_Pericytes_mesenchymal_Melanocyte_Preadipocyte_Monocytederived

Phase1 CAGE Peaks

Hg19::chr12:56122186..56122205,-	p7@CD63
Hg19::chr12:56122207..56122218,-	p16@CD63
Hg19::chr12:56122220..56122248,-	p4@CD63
Hg19::chr12:56122781..56122804,-	p1@CD63

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n
non-terminally differentiated cell	1.02e-36	180
somatic cell	1.29e-31	591
animal cell	2.09e-29	679
eukaryotic cell	2.09e-29	679
mesodermal cell	4.14e-26	119
contractile cell	2.46e-22	59
muscle precursor cell	2.66e-22	57
myoblast	2.66e-22	57
multi-potent skeletal muscle stem cell	2.66e-22	57
muscle cell	1.56e-20	54
embryonic cell	6.18e-20	248
smooth muscle cell	1.46e-19	42
smooth muscle myoblast	1.46e-19	42
electrically responsive cell	1.96e-16	60
electrically active cell	1.96e-16	60
multi fate stem cell	4.49e-16	430
vascular associated smooth muscle cell	1.62e-15	32
somatic stem cell	5.78e-15	436
fibroblast	6.47e-15	75
stem cell	5.50e-14	444
native cell	6.40e-14	722

Uber Anatomy

Ontology term	p-value	n
somite	2.39e-23	83
paraxial mesoderm	2.39e-23	83
presomitic mesoderm	2.39e-23	83
presumptive segmental plate	2.39e-23	83
trunk paraxial mesoderm	2.39e-23	83
presumptive paraxial mesoderm	2.39e-23	83
mesoderm	1.51e-22	448
mesoderm-derived structure	1.51e-22	448
presumptive mesoderm	1.51e-22	448
dermomyotome	5.58e-22	70
multilaminar epithelium	7.99e-21	82
musculoskeletal system	2.08e-20	167
trunk mesenchyme	2.92e-20	143
skeletal muscle tissue	6.74e-20	61
striated muscle tissue	6.74e-20	61
myotome	6.74e-20	61
muscle tissue	1.06e-18	63
musculature	1.06e-18	63
musculature of body	1.06e-18	63
vasculature	1.36e-17	79
vascular system	1.36e-17	79
trunk	1.16e-16	216
artery	1.11e-15	42
arterial blood vessel	1.11e-15	42
arterial system	1.11e-15	42
epithelial tube	8.35e-15	118
splanchnic layer of lateral plate mesoderm	1.80e-14	84
vessel	2.17e-14	69
multi-cellular organism	5.58e-14	659
blood vessel	6.91e-14	60
epithelial tube open at both ends	6.91e-14	60
blood vasculature	6.91e-14	60
vascular cord	6.91e-14	60
unilaminar epithelium	6.91e-14	138
anatomical system	3.68e-13	625
systemic artery	5.54e-13	33
systemic arterial system	5.54e-13	33
anatomical group	6.42e-13	626
mesenchyme	1.04e-11	238
entire embryonic mesenchyme	1.04e-11	238
lateral plate mesoderm	3.58e-11	216
cardiovascular system	4.12e-11	110
circulatory system	7.67e-11	113
germ layer	3.79e-09	604
embryonic tissue	3.79e-09	604
presumptive structure	3.79e-09	604
epiblast (generic)	3.79e-09	604
embryonic structure	4.51e-09	605
developing anatomical structure	4.51e-09	605
embryo	9.56e-09	612
aorta	5.23e-07	21
aortic system	5.23e-07	21

Disease

Ontology term	p-value	n
ovarian cancer	1.83e-07	14

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
ELF1#1997	4	4.25809795880754	0.00304152556578124	0.0160642201155369
EP300#2033	4	6.7739417262232	0.000474845982144264	0.00433576145560105
TCF7L2#6934	3	8.07763242235301	0.00297838168583462	0.0158598483091257
YY1#7528	4	4.91117074985386	0.0017187183805544	0.0106661850939878
ZBTB7A#51341	4	7.3519093078759	0.00034222354001599	0.00346063945543474

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.