Coexpression cluster:C1092

Full id: C1092_Hepatic_CD8_CD4_Endothelial_Renal_lymph_spleen

Phase1 CAGE Peaks

Hg19::chr7:150147807..150147847,+	p1@GIMAP8
Hg19::chr7:150147877..150147898,+	p3@GIMAP8
Hg19::chr7:150147899..150147910,+	p7@GIMAP8
Hg19::chr7:150147930..150147943,+	p4@GIMAP8
Hg19::chr7:150329353..150329364,-	p7@GIMAP6
Hg19::chr7:150329389..150329412,-	p3@GIMAP6
Hg19::chr7:150329421..150329482,-	p1@GIMAP6
Hg19::chr7:150329530..150329552,-	p2@GIMAP6

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

---

GO ID	GO name	FDR corrected p-value
GO:0005525	GTP binding	0.00118477953347309
GO:0032561	guanyl ribonucleotide binding	0.00118477953347309
GO:0019001	guanyl nucleotide binding	0.00118477953347309
GO:0032553	ribonucleotide binding	0.0133979824776932
GO:0032555	purine ribonucleotide binding	0.0133979824776932
GO:0017076	purine nucleotide binding	0.0133979824776932
GO:0000166	nucleotide binding	0.0157508168628174

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

---

Cell Type

Ontology term	p-value	n
hematopoietic stem cell	2.33e-21	172
angioblastic mesenchymal cell	2.33e-21	172
nongranular leukocyte	2.45e-21	119
leukocyte	4.61e-21	140
endothelial cell	3.12e-20	35
hematopoietic oligopotent progenitor cell	7.46e-20	165
hematopoietic multipotent progenitor cell	7.46e-20	165
hematopoietic lineage restricted progenitor cell	1.50e-19	124
hematopoietic cell	1.31e-18	182
endothelial cell of vascular tree	1.61e-18	24
blood vessel endothelial cell	1.33e-14	18
embryonic blood vessel endothelial progenitor cell	1.33e-14	18
monopoietic cell	5.19e-14	63
monocyte	5.19e-14	63
monoblast	5.19e-14	63
promonocyte	5.19e-14	63
myeloid lineage restricted progenitor cell	1.14e-13	70
myeloid leukocyte	1.50e-13	76
macrophage dendritic cell progenitor	1.99e-13	65
meso-epithelial cell	2.95e-13	44
granulocyte monocyte progenitor cell	3.92e-13	71
myeloid cell	6.26e-13	112
common myeloid progenitor	6.26e-13	112
CD14-positive, CD16-negative classical monocyte	6.31e-13	42
classical monocyte	4.57e-11	45
mature alpha-beta T cell	1.03e-10	18
alpha-beta T cell	1.03e-10	18
immature T cell	1.03e-10	18
mature T cell	1.03e-10	18
immature alpha-beta T cell	1.03e-10	18
T cell	7.26e-10	25
pro-T cell	7.26e-10	25
CD8-positive, alpha-beta T cell	4.09e-08	11
endothelial cell of artery	4.66e-08	9
lining cell	2.61e-07	57
barrier cell	2.61e-07	57
lymphoid lineage restricted progenitor cell	4.78e-07	52
lymphocyte	4.81e-07	53
common lymphoid progenitor	4.81e-07	53

Uber Anatomy

Ontology term	p-value	n
adult organism	6.91e-41	115
hemolymphoid system	8.09e-20	112
hematopoietic system	1.36e-16	102
blood island	1.36e-16	102
endothelium	1.33e-14	18
blood vessel endothelium	1.33e-14	18
cardiovascular system endothelium	1.33e-14	18
immune system	9.81e-14	115
lateral plate mesoderm	1.82e-13	216
simple squamous epithelium	7.18e-11	22
bone marrow	1.84e-10	80
neural tube	5.30e-09	57
neural rod	5.30e-09	57
future spinal cord	5.30e-09	57
neural keel	5.30e-09	57
squamous epithelium	1.80e-08	25
bone element	1.95e-08	86
endothelial tube	4.66e-08	9
arterial system endothelium	4.66e-08	9
endothelium of artery	4.66e-08	9
anterior neural tube	1.58e-07	42
regional part of forebrain	4.99e-07	41
forebrain	4.99e-07	41
future forebrain	4.99e-07	41

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

---

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

---

This analysis result is provided for C0 - C305 clusters.