Coexpression cluster:C44: Difference between revisions
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|ontology_enrichment_disease= | |ontology_enrichment_disease= | ||
|ontology_enrichment_uberon=UBERON:0002390!4.00e-28!102;UBERON:0003061!4.00e-28!102;UBERON:0002193!1.04e-26!112;UBERON:0007023!6.24e-24!115;UBERON:0002371!8.45e-18!80;UBERON:0001474!4.94e-17!86;UBERON:0002405!1.21e-14!115;UBERON:0004765!9.26e-11!101;UBERON:0001434!9.26e-11!101;UBERON:0001049!7.20e-10!57;UBERON:0005068!7.20e-10!57;UBERON:0006241!7.20e-10!57;UBERON:0007135!7.20e-10!57;UBERON:0000178!1.11e-08!15;UBERON:0000179!1.11e-08!15;UBERON:0000463!1.11e-08!15;UBERON:0003080!5.49e-08!42;UBERON:0002780!6.06e-08!41;UBERON:0001890!6.06e-08!41;UBERON:0006240!6.06e-08!41;UBERON:0001017!7.47e-08!82;UBERON:0002616!1.96e-07!59;UBERON:0005743!5.32e-07!86;UBERON:0001893!6.76e-07!34;UBERON:0003081!6.98e-07!216;UBERON:0002020!8.29e-07!34;UBERON:0003528!8.29e-07!34 | |ontology_enrichment_uberon=UBERON:0002390!4.00e-28!102;UBERON:0003061!4.00e-28!102;UBERON:0002193!1.04e-26!112;UBERON:0007023!6.24e-24!115;UBERON:0002371!8.45e-18!80;UBERON:0001474!4.94e-17!86;UBERON:0002405!1.21e-14!115;UBERON:0004765!9.26e-11!101;UBERON:0001434!9.26e-11!101;UBERON:0001049!7.20e-10!57;UBERON:0005068!7.20e-10!57;UBERON:0006241!7.20e-10!57;UBERON:0007135!7.20e-10!57;UBERON:0000178!1.11e-08!15;UBERON:0000179!1.11e-08!15;UBERON:0000463!1.11e-08!15;UBERON:0003080!5.49e-08!42;UBERON:0002780!6.06e-08!41;UBERON:0001890!6.06e-08!41;UBERON:0006240!6.06e-08!41;UBERON:0001017!7.47e-08!82;UBERON:0002616!1.96e-07!59;UBERON:0005743!5.32e-07!86;UBERON:0001893!6.76e-07!34;UBERON:0003081!6.98e-07!216;UBERON:0002020!8.29e-07!34;UBERON:0003528!8.29e-07!34 | ||
|tf_chipseq_enrich=BATF#10538;38:2.23574026112932:4.3826841135797e-06:0.000137289485944256!BCL11A#53335;43:2.94658591655822:4.40869296087417e-10:4.31123112491327e-08!CTCF#10664;102:1.32064287452573:0.00149335687932002:0.00954145963044803!EBF1#1879;108:2.32342613388757:3.94539802589067e-17:8.1272864778303e-15!ELF1#1997;122:1.25480181394811:0.00293512333054245:0.0156614389985451!IRF4#3662;45:2.38201224855914:9.5444060382598e-08:5.6316848713549e-06!MEF2A#4205;53:2.39949574447134:4.81563484558214e-09:3.88071055276044e-07!MEF2C#4208;25:2.49464701042416:3.60572293952078e-05:0.000698013156775923!NFKB1#4790;109:1.44492491120079:2.81991240645569e-05:0.000594967337005709!PAX5#5079;111:1.78821684531579:3.80555088093323e-10:3.77443426831705e-08!POLR2A#5430;220:1.14115869285695:0.00425133714032151:0.0202280364281566!POU2F2#5452;63:1.38571453052604:0.00503609050020758:0.0234669279325025!SPI1#6688;120:2.37806478507905:5.25676084299137e-20:1.33255059631353e-17!TCF12#6938;120:3.08245359483664:1.25299991275138e-29:4.97574364592554e-27!ZEB1#6935;62:2.52918547122637:2.40592385696892e-11:2.85212578544809e-09 | |||
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| ||
}} | }} |
Revision as of 13:03, 5 September 2012
Full id: C44_Dendritic_CD19_CD133_granulocyte_acute_thymus_immature
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
No results for this coexpression
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0003702 | RNA polymerase II transcription factor activity | 0.0119727516496982 |
GO:0005515 | protein binding | 0.0138965815428835 |
GO:0007242 | intracellular signaling cascade | 0.0219847442103654 |
GO:0006357 | regulation of transcription from RNA polymerase II promoter | 0.0296845419904631 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
Ontology term | p-value | n |
---|---|---|
leukocyte | 2.69e-55 | 140 |
hematopoietic stem cell | 1.83e-53 | 172 |
angioblastic mesenchymal cell | 1.83e-53 | 172 |
hematopoietic cell | 1.06e-50 | 182 |
hematopoietic oligopotent progenitor cell | 1.38e-48 | 165 |
hematopoietic multipotent progenitor cell | 1.38e-48 | 165 |
nongranular leukocyte | 4.29e-45 | 119 |
hematopoietic lineage restricted progenitor cell | 3.21e-44 | 124 |
lymphocyte | 3.86e-24 | 53 |
common lymphoid progenitor | 3.86e-24 | 53 |
myeloid cell | 1.60e-23 | 112 |
common myeloid progenitor | 1.60e-23 | 112 |
lymphoid lineage restricted progenitor cell | 1.61e-23 | 52 |
myeloid leukocyte | 7.31e-23 | 76 |
granulocyte monocyte progenitor cell | 2.27e-21 | 71 |
macrophage dendritic cell progenitor | 1.41e-19 | 65 |
myeloid lineage restricted progenitor cell | 5.07e-19 | 70 |
monopoietic cell | 1.85e-18 | 63 |
monocyte | 1.85e-18 | 63 |
monoblast | 1.85e-18 | 63 |
promonocyte | 1.85e-18 | 63 |
CD14-positive, CD16-negative classical monocyte | 2.62e-17 | 42 |
classical monocyte | 1.70e-15 | 45 |
lymphocyte of B lineage | 4.23e-15 | 24 |
pro-B cell | 4.23e-15 | 24 |
B cell | 3.04e-10 | 14 |
T cell | 1.81e-08 | 25 |
pro-T cell | 1.81e-08 | 25 |
Ontology term | p-value | n |
---|---|---|
hematopoietic system | 4.00e-28 | 102 |
blood island | 4.00e-28 | 102 |
hemolymphoid system | 1.04e-26 | 112 |
adult organism | 6.24e-24 | 115 |
bone marrow | 8.45e-18 | 80 |
bone element | 4.94e-17 | 86 |
immune system | 1.21e-14 | 115 |
skeletal element | 9.26e-11 | 101 |
skeletal system | 9.26e-11 | 101 |
neural tube | 7.20e-10 | 57 |
neural rod | 7.20e-10 | 57 |
future spinal cord | 7.20e-10 | 57 |
neural keel | 7.20e-10 | 57 |
blood | 1.11e-08 | 15 |
haemolymphatic fluid | 1.11e-08 | 15 |
organism substance | 1.11e-08 | 15 |
anterior neural tube | 5.49e-08 | 42 |
regional part of forebrain | 6.06e-08 | 41 |
forebrain | 6.06e-08 | 41 |
future forebrain | 6.06e-08 | 41 |
central nervous system | 7.47e-08 | 82 |
regional part of brain | 1.96e-07 | 59 |
telencephalon | 6.76e-07 | 34 |
lateral plate mesoderm | 6.98e-07 | 216 |
gray matter | 8.29e-07 | 34 |
brain grey matter | 8.29e-07 | 34 |
Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
{{{tfbs_overrepresentation_jaspar}}} |
ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)
TF | #promoters | Enrichment | p-value | q-value |
---|---|---|---|---|
BATF#10538 | 38 | 2.23574026112932 | 4.3826841135797e-06 | 0.000137289485944256 |
BCL11A#53335 | 43 | 2.94658591655822 | 4.40869296087417e-10 | 4.31123112491327e-08 |
CTCF#10664 | 102 | 1.32064287452573 | 0.00149335687932002 | 0.00954145963044803 |
EBF1#1879 | 108 | 2.32342613388757 | 3.94539802589067e-17 | 8.1272864778303e-15 |
ELF1#1997 | 122 | 1.25480181394811 | 0.00293512333054245 | 0.0156614389985451 |
IRF4#3662 | 45 | 2.38201224855914 | 9.5444060382598e-08 | 5.6316848713549e-06 |
MEF2A#4205 | 53 | 2.39949574447134 | 4.81563484558214e-09 | 3.88071055276044e-07 |
MEF2C#4208 | 25 | 2.49464701042416 | 3.60572293952078e-05 | 0.000698013156775923 |
NFKB1#4790 | 109 | 1.44492491120079 | 2.81991240645569e-05 | 0.000594967337005709 |
PAX5#5079 | 111 | 1.78821684531579 | 3.80555088093323e-10 | 3.77443426831705e-08 |
POLR2A#5430 | 220 | 1.14115869285695 | 0.00425133714032151 | 0.0202280364281566 |
POU2F2#5452 | 63 | 1.38571453052604 | 0.00503609050020758 | 0.0234669279325025 |
SPI1#6688 | 120 | 2.37806478507905 | 5.25676084299137e-20 | 1.33255059631353e-17 |
TCF12#6938 | 120 | 3.08245359483664 | 1.25299991275138e-29 | 4.97574364592554e-27 |
ZEB1#6935 | 62 | 2.52918547122637 | 2.40592385696892e-11 | 2.85212578544809e-09 |
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data
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