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{{Coexpression_clusters
{
|coexpression_dpi_cluster_scores_median=0.611567448769665,0

Latest revision as of 11:35, 17 September 2013


Full id: C987_skeletal_heart_left_mature_spinal_kidney_substantia



Phase1 CAGE Peaks

Hg19::chr11:111779473..111779528,+p@chr11:111779473..111779528
+
Hg19::chr11:111779507..111779528,-p15@CRYAB
Hg19::chr11:111779539..111779572,-p11@CRYAB
Hg19::chr11:111779550..111779574,+p@chr11:111779550..111779574
+
Hg19::chr11:111779604..111779626,+p@chr11:111779604..111779626
+
Hg19::chr11:111779606..111779681,-p5@CRYAB
Hg19::chr11:111781142..111781160,-p@chr11:111781142..111781160
-
Hg19::chr11:111782484..111782501,-p1@CRYAB


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
fat cell1.10e-1215
Uber Anatomy
Ontology termp-valuen
adult organism9.77e-53114
neural tube9.84e-2756
neural rod9.84e-2756
future spinal cord9.84e-2756
neural keel9.84e-2756
regional part of nervous system5.07e-2453
regional part of brain5.07e-2453
central nervous system2.87e-2281
neural plate7.29e-2182
presumptive neural plate7.29e-2182
nervous system2.37e-2089
regional part of forebrain1.37e-1941
forebrain1.37e-1941
anterior neural tube1.37e-1941
future forebrain1.37e-1941
neurectoderm5.46e-1986
brain8.78e-1968
future brain8.78e-1968
brain grey matter6.81e-1734
gray matter6.81e-1734
telencephalon1.13e-1634
structure with developmental contribution from neural crest1.84e-16132
regional part of telencephalon2.30e-1532
ecto-epithelium4.46e-15104
cerebral hemisphere6.02e-1532
pre-chordal neural plate1.25e-1361
ectoderm-derived structure6.59e-13171
ectoderm6.59e-13171
presumptive ectoderm6.59e-13171
cerebral cortex2.19e-1025
pallium2.19e-1025
regional part of cerebral cortex2.92e-1022
neocortex5.28e-0920
neural nucleus1.36e-089
nucleus of brain1.36e-089
posterior neural tube2.62e-0815
chordal neural plate2.62e-0815
basal ganglion2.82e-089
nuclear complex of neuraxis2.82e-089
aggregate regional part of brain2.82e-089
collection of basal ganglia2.82e-089
cerebral subcortex2.82e-089
telencephalic nucleus5.65e-077
organ system subdivision8.46e-07223
omentum9.05e-076
peritoneum9.05e-076
abdominal cavity9.05e-076
visceral peritoneum9.05e-076


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0264723
MA0004.10.455723
MA0006.10.300178
MA0007.10.437331
MA0009.10.918715
MA0014.10.00962431
MA0017.10.337901
MA0019.10.602411
MA0024.10.813542
MA0025.11.05265
MA0027.12.5321
MA0028.10.315574
MA0029.10.832916
MA0030.10.821423
MA0031.10.756713
MA0038.10.557409
MA0040.10.838784
MA0041.12.07464
MA0042.11.96909
MA0043.10.919032
MA0046.10.90778
MA0048.10.653157
MA0050.10.443405
MA0051.10.553205
MA0052.10.842664
MA0055.10.028436
MA0056.10
MA0057.10.0912556
MA0058.10.362328
MA0059.10.361075
MA0060.10.190336
MA0061.10.165998
MA0063.10
MA0066.10.557833
MA0067.11.23721
MA0068.10.133123
MA0069.12.08998
MA0070.10.892666
MA0071.10.518907
MA0072.10.888148
MA0073.10.000871324
MA0074.10.552456
MA0076.10.377799
MA0077.10.880402
MA0078.10.652193
MA0081.10.361233
MA0083.10.926258
MA0084.11.42483
MA0087.10.885691
MA0088.10.054222
MA0089.10
MA0090.10.391903
MA0091.10.458301
MA0092.10.421159
MA0093.10.303084
MA0095.10
MA0098.10
MA0100.10.571227
MA0101.11.49614
MA0103.10.792149
MA0105.10.279181
MA0106.10.59853
MA0107.10.666147
MA0108.20.753643
MA0109.10
MA0111.11.04489
MA0113.10.614917
MA0114.11.22129
MA0115.11.1606
MA0116.10.239768
MA0117.10.956472
MA0119.10.345493
MA0122.10.982472
MA0124.11.11898
MA0125.11.0347
MA0130.10
MA0131.10.670358
MA0132.10
MA0133.10
MA0135.10.949204
MA0136.10.564434
MA0139.10.155155
MA0140.10.516266
MA0141.10.359385
MA0142.10.724856
MA0143.10.615094
MA0144.10.218541
MA0145.10.0613434
MA0146.10.00761723
MA0147.10.243042
MA0148.10.480298
MA0149.10.506665
MA0062.20.161302
MA0035.22.21238
MA0039.20.00915579
MA0138.20.653421
MA0002.20.179788
MA0137.20.321796
MA0104.20.189646
MA0047.20.586412
MA0112.20.0572179
MA0065.20.0631316
MA0150.10.386144
MA0151.10
MA0152.10.52279
MA0153.11.01778
MA0154.11.45394
MA0155.10.43752
MA0156.11.55957
MA0157.10.697424
MA0158.10
MA0159.10.682702
MA0160.10.495355
MA0161.10
MA0162.10.0163939
MA0163.10.0104024
MA0164.10.627336
MA0080.20.303167
MA0018.20.599912
MA0099.20.523145
MA0079.22.25601e-06
MA0102.21.46209
MA0258.10.209744
MA0259.10.25092
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
FOXA1#316945.540709874692730.003444272925946160.0175240619726648



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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