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Coexpression cluster:C4710

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Full id: C4710_Monocytederived_Mesenchymal_Macrophage_papillotubular_Dendritic_Alveolar_CD14CD16



Phase1 CAGE Peaks

Hg19::chr7:98972311..98972326,+p2@ARPC1B
Hg19::chr7:98972327..98972338,+p3@ARPC1B
Hg19::chr7:98972345..98972360,+p1@ARPC1B


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
somatic cell3.65e-45591
native cell1.91e-39722
animal cell1.42e-33679
eukaryotic cell1.42e-33679
multi fate stem cell3.35e-28430
somatic stem cell5.08e-28436
stem cell1.03e-25444
monopoietic cell2.44e-2163
monocyte2.44e-2163
monoblast2.44e-2163
promonocyte2.44e-2163
myeloid leukocyte7.38e-2176
connective tissue cell1.48e-20365
macrophage dendritic cell progenitor1.69e-2065
mesenchymal cell2.34e-20358
nongranular leukocyte1.01e-19119
leukocyte2.05e-19140
hematopoietic stem cell1.51e-18172
angioblastic mesenchymal cell1.51e-18172
hematopoietic oligopotent progenitor cell3.54e-18165
hematopoietic multipotent progenitor cell3.54e-18165
hematopoietic cell4.43e-18182
granulocyte monocyte progenitor cell5.28e-1871
myeloid lineage restricted progenitor cell1.63e-1770
CD14-positive, CD16-negative classical monocyte2.79e-1742
myeloid cell3.11e-17112
common myeloid progenitor3.11e-17112
hematopoietic lineage restricted progenitor cell1.97e-16124
mesodermal cell1.46e-15119
motile cell1.67e-15390
classical monocyte1.15e-1445
contractile cell1.21e-0859
meso-epithelial cell1.56e-0844
smooth muscle cell1.68e-0842
smooth muscle myoblast1.68e-0842
endothelial cell3.59e-0835
muscle precursor cell3.90e-0857
myoblast3.90e-0857
multi-potent skeletal muscle stem cell3.90e-0857
vascular associated smooth muscle cell4.65e-0832
muscle cell5.50e-0854
lining cell8.98e-0857
barrier cell8.98e-0857
Uber Anatomy
Ontology termp-valuen
lateral plate mesoderm2.52e-33216
hemolymphoid system2.14e-23112
hematopoietic system6.92e-23102
blood island6.92e-23102
musculoskeletal system1.94e-21167
bone marrow1.88e-1980
connective tissue1.10e-18375
bone element2.15e-1686
skeletal element6.15e-16101
skeletal system6.15e-16101
immune system1.11e-14115
cardiovascular system2.82e-12110
mesoderm1.74e-11448
mesoderm-derived structure1.74e-11448
presumptive mesoderm1.74e-11448
circulatory system3.04e-11113
vessel2.22e-1069
blood vessel7.97e-1060
epithelial tube open at both ends7.97e-1060
blood vasculature7.97e-1060
vascular cord7.97e-1060
vasculature1.74e-0979
vascular system1.74e-0979
artery3.10e-0942
arterial blood vessel3.10e-0942
arterial system3.10e-0942
splanchnic layer of lateral plate mesoderm5.40e-0984
multilaminar epithelium1.69e-0882
epithelial tube4.19e-08118
dermomyotome2.89e-0770
somite2.98e-0783
paraxial mesoderm2.98e-0783
presomitic mesoderm2.98e-0783
presumptive segmental plate2.98e-0783
trunk paraxial mesoderm2.98e-0783
presumptive paraxial mesoderm2.98e-0783
systemic artery5.79e-0733
systemic arterial system5.79e-0733


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.