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Coexpression cluster:C1661

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Full id: C1661_CD4_Eosinophils_Neutrophils_CD8_CD14_CD14CD16_Whole



Phase1 CAGE Peaks

Hg19::chr12:12877074..12877097,+p@chr12:12877074..12877097
+
Hg19::chr15:65187070..65187088,+p@chr15:65187070..65187088
+
Hg19::chr15:65187099..65187110,+p@chr15:65187099..65187110
+
Hg19::chr22:37637659..37637679,-p2@M64595
Hg19::chr6:31785453..31785500,-p1@uc011dok.1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
hematopoietic stem cell2.77e-53172
angioblastic mesenchymal cell2.77e-53172
leukocyte4.83e-52140
hematopoietic oligopotent progenitor cell8.34e-51165
hematopoietic multipotent progenitor cell8.34e-51165
hematopoietic cell1.19e-49182
hematopoietic lineage restricted progenitor cell1.92e-45124
nongranular leukocyte5.84e-45119
myeloid leukocyte1.88e-2876
myeloid cell4.08e-28112
common myeloid progenitor4.08e-28112
myeloid lineage restricted progenitor cell2.17e-2470
granulocyte monocyte progenitor cell5.74e-2271
monopoietic cell1.21e-2163
monocyte1.21e-2163
monoblast1.21e-2163
promonocyte1.21e-2163
macrophage dendritic cell progenitor7.15e-2165
lymphoid lineage restricted progenitor cell1.12e-2052
lymphocyte1.50e-2053
common lymphoid progenitor1.50e-2053
CD14-positive, CD16-negative classical monocyte2.06e-1942
classical monocyte2.40e-1945
T cell1.07e-1225
pro-T cell1.07e-1225
mature alpha-beta T cell1.31e-1218
alpha-beta T cell1.31e-1218
immature T cell1.31e-1218
mature T cell1.31e-1218
immature alpha-beta T cell1.31e-1218
mesenchymal cell1.56e-12358
connective tissue cell1.07e-11365
CD8-positive, alpha-beta T cell3.68e-0811
motile cell6.71e-08390
lymphocyte of B lineage9.19e-0824
pro-B cell9.19e-0824
multi fate stem cell3.12e-07430
somatic stem cell5.36e-07436
stem cell5.78e-07444
native cell9.77e-07722
Uber Anatomy
Ontology termp-valuen
hemolymphoid system4.06e-30112
hematopoietic system1.72e-29102
blood island1.72e-29102
bone marrow2.03e-1980
bone element2.07e-1786
immune system1.91e-16115
lateral plate mesoderm8.50e-13216
skeletal element1.85e-12101
skeletal system1.85e-12101
connective tissue8.91e-11375
blood5.32e-0815
haemolymphatic fluid5.32e-0815
organism substance5.32e-0815


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.