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Coexpression cluster:C2219

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Full id: C2219_Smooth_Mesenchymal_Pericytes_mesenchymal_Melanocyte_Preadipocyte_Monocytederived



Phase1 CAGE Peaks

Hg19::chr12:56122186..56122205,-p7@CD63
Hg19::chr12:56122207..56122218,-p16@CD63
Hg19::chr12:56122220..56122248,-p4@CD63
Hg19::chr12:56122781..56122804,-p1@CD63


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Uber Anatomy
Ontology termp-valuen
somite2.39e-2383
paraxial mesoderm2.39e-2383
presomitic mesoderm2.39e-2383
presumptive segmental plate2.39e-2383
trunk paraxial mesoderm2.39e-2383
presumptive paraxial mesoderm2.39e-2383
mesoderm1.51e-22448
mesoderm-derived structure1.51e-22448
presumptive mesoderm1.51e-22448
dermomyotome5.58e-2270
multilaminar epithelium7.99e-2182
musculoskeletal system2.08e-20167
trunk mesenchyme2.92e-20143
skeletal muscle tissue6.74e-2061
striated muscle tissue6.74e-2061
myotome6.74e-2061
muscle tissue1.06e-1863
musculature1.06e-1863
musculature of body1.06e-1863
vasculature1.36e-1779
vascular system1.36e-1779
trunk1.16e-16216
artery1.11e-1542
arterial blood vessel1.11e-1542
arterial system1.11e-1542
epithelial tube8.35e-15118
splanchnic layer of lateral plate mesoderm1.80e-1484
vessel2.17e-1469
multi-cellular organism5.58e-14659
blood vessel6.91e-1460
epithelial tube open at both ends6.91e-1460
blood vasculature6.91e-1460
vascular cord6.91e-1460
unilaminar epithelium6.91e-14138
anatomical system3.68e-13625
systemic artery5.54e-1333
systemic arterial system5.54e-1333
anatomical group6.42e-13626
mesenchyme1.04e-11238
entire embryonic mesenchyme1.04e-11238
lateral plate mesoderm3.58e-11216
cardiovascular system4.12e-11110
circulatory system7.67e-11113
germ layer3.79e-09604
embryonic tissue3.79e-09604
presumptive structure3.79e-09604
epiblast (generic)3.79e-09604
embryonic structure4.51e-09605
developing anatomical structure4.51e-09605
embryo9.56e-09612
aorta5.23e-0721
aortic system5.23e-0721
Disease
Ontology termp-valuen
ovarian cancer1.83e-0714


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.