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Coexpression cluster:C3326

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Full id: C3326_parietal_pineal_neuroectodermal_Cardiac_occipital_temporal_Neurons



Phase1 CAGE Peaks

Hg19::chr12:7045535..7045576,+p3@ATN1
Hg19::chr12:7045821..7045845,+p2@L10377
Hg19::chr12:7051290..7051449,+p@chr12:7051290..7051449
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br>disease_data<br>


Uber Anatomy
Ontology termp-valuen
central nervous system3.34e-2682
neural tube1.11e-2557
neural rod1.11e-2557
future spinal cord1.11e-2557
neural keel1.11e-2557
regional part of nervous system1.94e-2594
nervous system1.94e-2594
brain1.16e-2269
future brain1.16e-2269
regional part of brain1.08e-2159
neurectoderm7.88e-2190
anterior neural tube3.36e-2042
regional part of forebrain9.25e-2041
forebrain9.25e-2041
future forebrain9.25e-2041
neural plate2.84e-1986
presumptive neural plate2.84e-1986
ectoderm1.87e-17173
presumptive ectoderm1.87e-17173
gray matter2.54e-1734
brain grey matter2.54e-1734
telencephalon3.26e-1634
regional part of telencephalon3.60e-1633
ectoderm-derived structure3.81e-16169
cerebral hemisphere1.04e-1532
pre-chordal neural plate2.72e-1461
head3.74e-13123
cerebral cortex7.30e-1325
pallium7.30e-1325
adult organism7.38e-13115
regional part of cerebral cortex1.59e-1222
anterior region of body8.98e-12129
craniocervical region8.98e-12129
neocortex2.64e-1120
organism subdivision1.90e-10365
anatomical cluster3.38e-08286
multi-tissue structure6.88e-08347
organ part1.03e-07219
anatomical conduit1.12e-07241
epithelium1.73e-07309
multi-cellular organism3.22e-07659
tube3.73e-07194
cell layer4.45e-07312
Disease
Ontology termp-valuen
cell type cancer1.66e-09143


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.