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Coexpression cluster:C2386

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Full id: C2386_mesothelioma_Mast_pons_mature_endometrial_Mesothelial_medulla



Phase1 CAGE Peaks

Hg19::chr16:71392619..71392635,+p1@CALB2
Hg19::chr16:71417294..71417313,+p@chr16:71417294..71417313
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Hg19::chr16:71423775..71423790,+p@chr16:71423775..71423790
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Hg19::chr16:71423847..71423869,+p@chr16:71423847..71423869
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Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Uber Anatomy
Ontology termp-valuen
neural tube2.37e-1256
neural rod2.37e-1256
future spinal cord2.37e-1256
neural keel2.37e-1256
adult organism3.16e-12114
central nervous system8.71e-1281
regional part of nervous system2.46e-1153
regional part of brain2.46e-1153
nervous system3.17e-1089
brain2.22e-0968
future brain2.22e-0968
female gonad1.36e-0813
external genitalia1.79e-0822
gonad7.65e-0821
indifferent external genitalia7.65e-0821
indifferent gonad7.65e-0821
gonad primordium7.65e-0821
posterior neural tube1.39e-0715
chordal neural plate1.39e-0715
right ovary1.61e-075
regional part of cerebral cortex1.83e-0722
neocortex3.87e-0720
neural plate5.13e-0782
presumptive neural plate5.13e-0782
regional part of forebrain5.80e-0741
forebrain5.80e-0741
anterior neural tube5.80e-0741
future forebrain5.80e-0741
brain grey matter6.29e-0734
gray matter6.29e-0734
Disease
Ontology termp-valuen
ovarian cancer1.75e-1214
female reproductive organ cancer3.36e-0827
reproductive organ cancer2.40e-0729


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.