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Coexpression cluster:C883

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Full id: C883_CD14_CD14CD16_Monocytederived_spleen_Macrophage_Basophils_Peripheral



Phase1 CAGE Peaks

Hg19::chr11:60145301..60145329,-p@chr11:60145301..60145329
-
Hg19::chr11:60145332..60145348,-p@chr11:60145332..60145348
-
Hg19::chr11:60145948..60145960,+p2@MS4A14
p2@MS4A7
Hg19::chr11:60145967..60145978,+p3@MS4A7
Hg19::chr11:60145997..60146040,+p1@MS4A14
p1@MS4A7
Hg19::chr11:60146052..60146068,+p4@MS4A7
Hg19::chr11:60146080..60146091,+p5@MS4A7
Hg19::chr11:60150636..60150652,+p7@MS4A7
Hg19::chr11:60161612..60161616,+p@chr11:60161612..60161616
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
monopoietic cell3.88e-6959
monocyte3.88e-6959
monoblast3.88e-6959
promonocyte3.88e-6959
macrophage dendritic cell progenitor9.24e-6961
granulocyte monocyte progenitor cell2.06e-6467
myeloid lineage restricted progenitor cell2.83e-6366
myeloid leukocyte2.86e-6372
defensive cell1.04e-6148
phagocyte1.04e-6148
classical monocyte2.51e-5442
CD14-positive, CD16-negative classical monocyte2.51e-5442
nongranular leukocyte5.79e-48115
leukocyte1.43e-44136
hematopoietic lineage restricted progenitor cell4.47e-44120
myeloid cell5.46e-44108
common myeloid progenitor5.46e-44108
hematopoietic stem cell4.62e-38168
angioblastic mesenchymal cell4.62e-38168
hematopoietic oligopotent progenitor cell5.96e-36161
hematopoietic multipotent progenitor cell5.96e-36161
hematopoietic cell1.23e-34177
stuff accumulating cell1.01e-2687
intermediate monocyte4.50e-139
CD14-positive, CD16-positive monocyte4.50e-139
macrophage1.55e-086
Uber Anatomy
Ontology termp-valuen
hematopoietic system4.35e-7098
blood island4.35e-7098
hemolymphoid system1.70e-64108
bone marrow5.57e-5876
immune system1.44e-5493
bone element4.97e-5282
skeletal element2.40e-4590
skeletal system1.59e-38100
adult organism5.80e-28114
lateral plate mesoderm2.80e-27203
musculoskeletal system1.10e-16167
mesoderm4.70e-13315
mesoderm-derived structure4.70e-13315
presumptive mesoderm4.70e-13315
blood7.54e-1015
haemolymphatic fluid7.54e-1015
organism substance7.54e-1015
organ3.84e-07503
germ layer4.47e-07560
germ layer / neural crest4.47e-07560
embryonic tissue4.47e-07560
presumptive structure4.47e-07560
germ layer / neural crest derived structure4.47e-07560
epiblast (generic)4.47e-07560
tissue4.74e-07773
embryonic structure8.44e-07564


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BCL11A#53335515.76080839089286.07835896292738e-060.000180859752629394
BCLAF1#9774512.02924867228992.26104873625909e-050.000494020227962684
EBF1#187976.927251991775896.58055964035478e-060.000192727725260519
MEF2A#4205510.41290606091344.53864389110116e-050.000798267816340038
NFKB1#479053.048924124552130.01316873026498510.046599207838476
PAX5#507975.187439857582764.62776729125731e-050.000812438036866066
SPI1#668876.381140506628791.14766724697107e-050.000292273151929802
SRF#6722710.73113864835273.31352184322677e-071.65658644224395e-05
ZEB1#693559.38246223196887.48833020047875e-050.00116017462959175



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.